Skip to content
This repository

HTTPS clone URL

Subversion checkout URL

You can clone with HTTPS or Subversion.

Download ZIP

Aggregate Data Drug Information System

Fetching latest commit…

Cannot retrieve the latest commit at this time

README.md

ADDIS - Aggregate Data Drug Information System

ADDIS is a software developed within the Dutch Escher-project for managing and analyzing clinical trial information.

ADDIS comes with a built-in example modeled on the paper: Hansen et al., Annals of internal medicine, 143(6): 415-426, 2005. All data was extracted by us from the original papers.

Requirements

ADDIS is made in Java, and requires Java 6 (JRE 1.6) or newer. Most modern operating systems ship with a suitable JRE.

Versions

1.12.4: The network meta-analysis simulation can be continued if it has not converged yet, and there is a new GUI for checking convergence. The benefit-risk analysis now uses the full covariance information from network meta-analysis. Reduced download from 30MB to 15MB. Bugfixes.

1.12.3: Bugfix release.

1.12.2: Bugfix release.

1.12.1: Input name of analyses in the first step of the wizard, not in a pop-up dialog at the very end.

1.12: Add BRAT table and its value tree to benefit-risk view, allow selection of baseline in benefit-risk analysis, enable BRAT description of benefit-risk analysis, improve performance of network meta-analysis wizard, clarify error dialog with bug reporting instructions, fix many bugs.

1.10.1: Bugfix release

1.10: Enable combination treatment. Add "free text" ('Other') activity. Allow multiple moments of measurement for each outcome. Add installer and double-click loading of .addis data files on Windows.

1.8: Input study design (time structure), allow missing measurements, generate summary of efficacy table according to EMA D80 template, support of primary/secondary endpoints.

1.6.2: Bugfix release

1.6.1: Performance improvements for network meta-analysis, rank probability table.

1.6: User interface improvements, risk-based sampling in MetaBR, new schema-based XML format, added note taking in study wizard.

1.4: Lynd & O'Brien benefit-risk analysis, corrected meta-analysis, network meta-analysis enhancements (assessment of convergence, variance parameters, node-splitting analysis, R-dump of results, memory management), tabbed views.

1.2.1: Bugfix release

1.2: Benefit-risk models based on a single study.

1.0: Welcome screen, limited editing, links to various information systems (PubMed, medicines.org.uk, whocc.no) and many minor improvements.

0.10: Benefit-risk analysis, baseline effect (heuristic) estimation

0.8.1: Faster network meta-analysis (updated library), minor fixes

0.8: Network meta-analysis, XML import/export

0.6: Added add-study-wizard, import from ClinicalTrials.gov

0.4.1: Fixed example data (studies Org 022 and 023), changed domain to be version-specific.

0.4: Added meta-analysis, removed combined studies and MCDA-hookup. Lots of minor changes.

0.2: Initial release.

Building ADDIS from source

All releases as well as a nightly build (see the DrugIS website) are distributed in a compiled format. However, we also provide source for external development / verification. The sources can be checked out of the ADDIS Git repository.

In order to compile ADDIS, you need:

  • Java >= 1.6
  • Maven 2
  • Other dependencies should be downloaded automatically by Maven2

Building is automatic with "mvn package".

Developing ADDIS using Eclipse

First, let Maven configure your workspace for use with Maven:

$ mvn eclipse:configure-workspace -Declipse.workspace=WORKSPACE_DIR

Use Maven to generate the eclipse project:

$ cd SOURCE_DIR
$ mvn eclipse:eclipse

Then import the project into Eclipse (File -> Import -> Existing projects).

License

ADDIS is open source, and licensed under GPLv3. See LICENSE.txt for more information.

Contact

For contact information, see the ADDIS website.

ADDIS Development Team

Something went wrong with that request. Please try again.