diff --git a/scripts/populate_tox/populate_tox.py b/scripts/populate_tox/populate_tox.py
index 5734167a6a..0d5f5043ed 100644
--- a/scripts/populate_tox/populate_tox.py
+++ b/scripts/populate_tox/populate_tox.py
@@ -438,7 +438,7 @@ def _render_dependencies(integration: str, releases: list[Version]) -> list[str]
             for dep in deps:
                 rendered.append(f"{{{constraint}}}-{integration}: {dep}")
         else:
-            restriction = SpecifierSet(constraint)
+            restriction = SpecifierSet(constraint, prereleases=True)
             for release in releases:
                 if release in restriction:
                     for dep in deps:
diff --git a/tox.ini b/tox.ini
index d325d6071e..dc289b4587 100644
--- a/tox.ini
+++ b/tox.ini
@@ -10,7 +10,7 @@
 # The file (and all resulting CI YAMLs) then need to be regenerated via
 # "scripts/generate-test-files.sh".
 #
-# Last generated: 2025-09-17T14:43:06.969007+00:00
+# Last generated: 2025-09-18T06:43:59.191429+00:00
 
 [tox]
 requires =
@@ -95,7 +95,7 @@ envlist =
     {py3.8,py3.11,py3.12}-anthropic-v0.16.0
     {py3.8,py3.11,py3.12}-anthropic-v0.33.1
     {py3.8,py3.11,py3.12}-anthropic-v0.50.0
-    {py3.8,py3.12,py3.13}-anthropic-v0.67.0
+    {py3.8,py3.12,py3.13}-anthropic-v0.68.0
 
     {py3.9,py3.10,py3.11}-cohere-v5.4.0
     {py3.9,py3.11,py3.12}-cohere-v5.9.4
@@ -111,14 +111,14 @@ envlist =
     {py3.9,py3.12,py3.13}-langchain-notiktoken-v0.3.27
 
     {py3.8,py3.11,py3.12}-openai-base-v1.0.1
-    {py3.8,py3.11,py3.12}-openai-base-v1.36.1
-    {py3.8,py3.11,py3.12}-openai-base-v1.71.0
-    {py3.8,py3.12,py3.13}-openai-base-v1.107.3
+    {py3.8,py3.11,py3.12}-openai-base-v1.37.2
+    {py3.8,py3.11,py3.12}-openai-base-v1.73.0
+    {py3.8,py3.12,py3.13}-openai-base-v1.108.0
 
     {py3.8,py3.11,py3.12}-openai-notiktoken-v1.0.1
-    {py3.8,py3.11,py3.12}-openai-notiktoken-v1.36.1
-    {py3.8,py3.11,py3.12}-openai-notiktoken-v1.71.0
-    {py3.8,py3.12,py3.13}-openai-notiktoken-v1.107.3
+    {py3.8,py3.11,py3.12}-openai-notiktoken-v1.37.2
+    {py3.8,py3.11,py3.12}-openai-notiktoken-v1.73.0
+    {py3.8,py3.12,py3.13}-openai-notiktoken-v1.108.0
 
     {py3.9,py3.12,py3.13}-langgraph-v0.6.7
     {py3.10,py3.12,py3.13}-langgraph-v1.0.0a3
@@ -138,7 +138,7 @@ envlist =
     {py3.6,py3.7}-boto3-v1.12.49
     {py3.6,py3.9,py3.10}-boto3-v1.20.54
     {py3.7,py3.11,py3.12}-boto3-v1.28.85
-    {py3.9,py3.12,py3.13}-boto3-v1.40.32
+    {py3.9,py3.12,py3.13}-boto3-v1.40.33
 
     {py3.6,py3.7,py3.8}-chalice-v1.16.0
     {py3.6,py3.7,py3.8}-chalice-v1.21.9
@@ -254,6 +254,7 @@ envlist =
     {py3.8,py3.11,py3.12}-django-v4.2.24
     {py3.10,py3.11,py3.12}-django-v5.0.14
     {py3.10,py3.12,py3.13}-django-v5.2.6
+    {py3.12,py3.13}-django-v6.0a1
 
     {py3.6,py3.7,py3.8}-flask-v1.1.4
     {py3.8,py3.12,py3.13}-flask-v2.3.3
@@ -459,7 +460,7 @@ deps =
     anthropic-v0.16.0: anthropic==0.16.0
     anthropic-v0.33.1: anthropic==0.33.1
     anthropic-v0.50.0: anthropic==0.50.0
-    anthropic-v0.67.0: anthropic==0.67.0
+    anthropic-v0.68.0: anthropic==0.68.0
     anthropic: pytest-asyncio
     anthropic-v0.16.0: httpx<0.28.0
     anthropic-v0.33.1: httpx<0.28.0
@@ -485,21 +486,21 @@ deps =
     langchain-notiktoken-v0.3.27: langchain-community
 
     openai-base-v1.0.1: openai==1.0.1
-    openai-base-v1.36.1: openai==1.36.1
-    openai-base-v1.71.0: openai==1.71.0
-    openai-base-v1.107.3: openai==1.107.3
+    openai-base-v1.37.2: openai==1.37.2
+    openai-base-v1.73.0: openai==1.73.0
+    openai-base-v1.108.0: openai==1.108.0
     openai-base: pytest-asyncio
     openai-base: tiktoken
     openai-base-v1.0.1: httpx<0.28
-    openai-base-v1.36.1: httpx<0.28
+    openai-base-v1.37.2: httpx<0.28
 
     openai-notiktoken-v1.0.1: openai==1.0.1
-    openai-notiktoken-v1.36.1: openai==1.36.1
-    openai-notiktoken-v1.71.0: openai==1.71.0
-    openai-notiktoken-v1.107.3: openai==1.107.3
+    openai-notiktoken-v1.37.2: openai==1.37.2
+    openai-notiktoken-v1.73.0: openai==1.73.0
+    openai-notiktoken-v1.108.0: openai==1.108.0
     openai-notiktoken: pytest-asyncio
     openai-notiktoken-v1.0.1: httpx<0.28
-    openai-notiktoken-v1.36.1: httpx<0.28
+    openai-notiktoken-v1.37.2: httpx<0.28
 
     langgraph-v0.6.7: langgraph==0.6.7
     langgraph-v1.0.0a3: langgraph==1.0.0a3
@@ -521,7 +522,7 @@ deps =
     boto3-v1.12.49: boto3==1.12.49
     boto3-v1.20.54: boto3==1.20.54
     boto3-v1.28.85: boto3==1.28.85
-    boto3-v1.40.32: boto3==1.40.32
+    boto3-v1.40.33: boto3==1.40.33
     {py3.7,py3.8}-boto3: urllib3<2.0.0
 
     chalice-v1.16.0: chalice==1.16.0
@@ -665,6 +666,7 @@ deps =
     django-v4.2.24: django==4.2.24
     django-v5.0.14: django==5.0.14
     django-v5.2.6: django==5.2.6
+    django-v6.0a1: django==6.0a1
     django: psycopg2-binary
     django: djangorestframework
     django: pytest-django
@@ -674,11 +676,13 @@ deps =
     django-v4.2.24: channels[daphne]
     django-v5.0.14: channels[daphne]
     django-v5.2.6: channels[daphne]
+    django-v6.0a1: channels[daphne]
     django-v2.2.28: six
     django-v3.2.25: pytest-asyncio
     django-v4.2.24: pytest-asyncio
     django-v5.0.14: pytest-asyncio
     django-v5.2.6: pytest-asyncio
+    django-v6.0a1: pytest-asyncio
     django-v1.11.29: djangorestframework>=3.0,<4.0
     django-v1.11.29: Werkzeug<2.1.0
     django-v2.2.28: djangorestframework>=3.0,<4.0