diff --git a/static/app/views/insights/crons/components/monitorHeaderActions.spec.tsx b/static/app/views/insights/crons/components/monitorHeaderActions.spec.tsx
new file mode 100644
index 00000000000000..cf03b155a47953
--- /dev/null
+++ b/static/app/views/insights/crons/components/monitorHeaderActions.spec.tsx
@@ -0,0 +1,82 @@
+import {MonitorFixture} from 'sentry-fixture/monitor';
+import {OrganizationFixture} from 'sentry-fixture/organization';
+
+import {render, screen, userEvent} from 'sentry-test/reactTestingLibrary';
+
+import MonitorHeaderActions from 'sentry/views/insights/crons/components/monitorHeaderActions';
+
+describe('MonitorHeaderActions', () => {
+  const organization = OrganizationFixture();
+
+  it('disables mute button when monitor has no environments', async () => {
+    const monitor = MonitorFixture({
+      environments: [],
+    });
+
+    render(
+      <MonitorHeaderActions
+        monitor={monitor}
+        orgSlug={organization.slug}
+        onUpdate={jest.fn()}
+      />,
+      {organization}
+    );
+
+    const muteButton = screen.getByRole('button', {name: 'Mute'});
+    expect(muteButton).toBeDisabled();
+
+    await userEvent.hover(muteButton);
+    expect(
+      await screen.findByText(
+        'Muting is only available when there are monitor environments'
+      )
+    ).toBeInTheDocument();
+  });
+
+  it('enables mute button when monitor has environments', async () => {
+    const monitor = MonitorFixture();
+
+    const updateMock = MockApiClient.addMockResponse({
+      url: `/projects/${organization.slug}/${monitor.project.slug}/monitors/${monitor.slug}/`,
+      method: 'PUT',
+      body: {...monitor, isMuted: true},
+    });
+
+    render(
+      <MonitorHeaderActions
+        monitor={monitor}
+        orgSlug={organization.slug}
+        onUpdate={jest.fn()}
+      />,
+      {organization}
+    );
+
+    const muteButton = screen.getByRole('button', {name: 'Mute'});
+    expect(muteButton).toBeEnabled();
+
+    await userEvent.click(muteButton);
+    expect(updateMock).toHaveBeenCalledWith(
+      expect.anything(),
+      expect.objectContaining({
+        data: {isMuted: true},
+      })
+    );
+  });
+
+  it('shows unmute button when monitor is muted', () => {
+    const monitor = MonitorFixture({
+      isMuted: true,
+    });
+
+    render(
+      <MonitorHeaderActions
+        monitor={monitor}
+        orgSlug={organization.slug}
+        onUpdate={jest.fn()}
+      />,
+      {organization}
+    );
+
+    expect(screen.getByRole('button', {name: 'Unmute'})).toBeInTheDocument();
+  });
+});
diff --git a/static/app/views/insights/crons/components/monitorHeaderActions.tsx b/static/app/views/insights/crons/components/monitorHeaderActions.tsx
index a8e04a3639fc2f..e870df97278563 100644
--- a/static/app/views/insights/crons/components/monitorHeaderActions.tsx
+++ b/static/app/views/insights/crons/components/monitorHeaderActions.tsx
@@ -71,6 +71,16 @@ function MonitorHeaderActions({monitor, orgSlug, onUpdate}: Props) {
     disableProps.title = permissionTooltipText;
   }
 
+  const hasEnvironments = monitor.environments.length > 0;
+  const muteDisableProps = {...disableProps};
+
+  if (!hasEnvironments) {
+    muteDisableProps.disabled = true;
+    muteDisableProps.title = t(
+      'Muting is only available when there are monitor environments'
+    );
+  }
+
   return (
     <ButtonBar>
       <FeedbackWidgetButton />
@@ -78,7 +88,7 @@ function MonitorHeaderActions({monitor, orgSlug, onUpdate}: Props) {
         size="sm"
         icon={monitor.isMuted ? <IconSubscribed /> : <IconUnsubscribed />}
         onClick={() => handleUpdate({isMuted: !monitor.isMuted})}
-        {...disableProps}
+        {...muteDisableProps}
       >
         {monitor.isMuted ? t('Unmute') : t('Mute')}
       </Button>