diff --git a/assets/images/help/settings/accessibility-tab.png b/assets/images/help/settings/accessibility-tab.png
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diff --git a/assets/images/help/settings/disable-character-key-shortcuts.png b/assets/images/help/settings/disable-character-key-shortcuts.png
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diff --git a/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/index.md b/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/index.md
index ee9bf9b124ec..6ba64d8d33d2 100644
--- a/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/index.md
+++ b/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/index.md
@@ -23,6 +23,7 @@ children:
   - /deleting-your-user-account
   - /permission-levels-for-a-user-account-repository
   - /permission-levels-for-user-owned-project-boards
+  - /managing-accessibility-settings
   - /managing-the-default-branch-name-for-your-repositories
   - /managing-security-and-analysis-settings-for-your-user-account
   - /managing-access-to-your-user-accounts-project-boards
diff --git a/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/managing-accessibility-settings.md b/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/managing-accessibility-settings.md
new file mode 100644
index 000000000000..b79c2b3be4c6
--- /dev/null
+++ b/content/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/managing-accessibility-settings.md
@@ -0,0 +1,22 @@
+---
+title: Managing accessibility settings
+intro: 'You can disable character key shortcuts on {% data variables.product.prodname_dotcom %} in your accessibility settings.'
+versions:
+  fpt: '*'
+  ghes: '>=3.4'
+  feature: keyboard-shortcut-accessibility-setting
+---
+
+## About accessibility settings
+
+{% data variables.product.product_name %} includes a variety of keyboard shortcuts so that you can perform actions across the site without using your mouse to navigate. While shortcuts are useful to save time, they can sometimes make {% data variables.product.prodname_dotcom %} harder to use and less accessible.
+
+All keyboard shortcuts are enabled by default on {% data variables.product.product_name %}, but you can choose to disable character key shortcuts in your accessibility settings. This setting does not affect keyboard shortcuts provided by your web browser or {% data variables.product.prodname_dotcom %} shortcuts that use a modifier key such as `control` or `command`.
+
+## Managing character key shortcuts
+
+{% data reusables.user_settings.access_settings %}
+{% data reusables.user_settings.accessibility_settings %}
+1. Select or deselect the **Enable character key shortcuts** checkbox. 
+   ![Screenshot of the 'Enable character key shortcuts' checkbox](/assets/images/help/settings/disable-character-key-shortcuts.png)
+2. Click **Save**.
diff --git a/content/get-started/using-github/keyboard-shortcuts.md b/content/get-started/using-github/keyboard-shortcuts.md
index 77555bfdc44e..bc0dfabdb636 100644
--- a/content/get-started/using-github/keyboard-shortcuts.md
+++ b/content/get-started/using-github/keyboard-shortcuts.md
@@ -18,6 +18,9 @@ versions:
 
 Typing <kbd>?</kbd> on {% data variables.product.prodname_dotcom %} brings up a dialog box that lists the keyboard shortcuts available for that page. You can use these keyboard shortcuts to perform actions across the site without using your mouse to navigate.
 
+{% if keyboard-shortcut-accessibility-setting %}
+You can disable character key shortcuts, while still allowing shortcuts that use modifier keys, in your accessibility settings. For more information, see "[Managing accessibility settings](/account-and-profile/setting-up-and-managing-your-github-user-account/managing-user-account-settings/managing-accessibility-settings)."{% endif %}
+
 Below is a list of some of the available keyboard shortcuts.
 {% if command-palette %}
 The {% data variables.product.prodname_command_palette %} also gives you quick access to a wide range of actions, without the need to remember keyboard shortcuts. For more information, see "[{% data variables.product.prodname_command_palette %}](/get-started/using-github/github-command-palette)."{% endif %}
diff --git a/data/features/keyboard-shortcut-accessibility-setting.yml b/data/features/keyboard-shortcut-accessibility-setting.yml
new file mode 100644
index 000000000000..f5ac118b9809
--- /dev/null
+++ b/data/features/keyboard-shortcut-accessibility-setting.yml
@@ -0,0 +1,7 @@
+# Reference: #4999.
+# Documentation for the security manager org-level role
+versions:
+  fpt: '*'
+  ghes: '>=3.4'
+  ghae: 'ghae-issue-5430'
+  ghec: '*'
diff --git a/data/reusables/user_settings/accessibility_settings.md b/data/reusables/user_settings/accessibility_settings.md
new file mode 100644
index 000000000000..073c3c145647
--- /dev/null
+++ b/data/reusables/user_settings/accessibility_settings.md
@@ -0,0 +1,2 @@
+1. In the navigation on the left hand side, click the **Accessibility** link.
+![Screenshot of the user settings navigation. The Accessibility link is highlighted.](/assets/images/help/settings/accessibility-tab.png)