diff --git a/.eslintrc.json b/.eslintrc.json
index f726865..c046913 100644
--- a/.eslintrc.json
+++ b/.eslintrc.json
@@ -7,7 +7,8 @@
     "no-invalid-this": "off",
     "@typescript-eslint/no-invalid-this": ["error"],
     "import/extensions": ["error", "always"],
-    "github/no-inner-html": "off"
+    "github/no-inner-html": "off",
+    "@typescript-eslint/no-unused-vars": ["error", { "vars": "all", "argsIgnorePattern": "^_" }]
   },
   "overrides": [
     {
diff --git a/README.md b/README.md
index 4bb8ec2..6a89066 100644
--- a/README.md
+++ b/README.md
@@ -245,3 +245,30 @@ render(html`<div>${until(request, timeout, loading)}</div>`)
 // ^ renders <div>Loading...</div>
 // After 2000ms will render <div>Failed to load</div>
 ```
+
+### CSP Trusted Types
+
+You can call `TemplateResult.setCSPTrustedTypesPolicy(policy: TrustedTypePolicy | Promise<TrustedTypePolicy> | null)` from JavaScript to set a [CSP trusted types policy](https://web.dev/trusted-types/), which can perform (synchronous) filtering or rejection of the rendered template:
+
+```ts
+import {TemplateResult} from "@github/jtml";
+import DOMPurify from "dompurify"; // Using https://github.com/cure53/DOMPurify
+
+// This policy removes all HTML markup except links.
+const policy = trustedTypes.createPolicy("links-only", {
+  createHTML: (htmlText: string) => {
+    return DOMPurify.sanitize(htmlText, {
+      ALLOWED_TAGS: ["a"],
+      ALLOWED_ATTR: ["href"],
+      RETURN_TRUSTED_TYPE: true,
+    });
+  },
+});
+TemplateResult.setCSPTrustedTypesPolicy(policy);
+```
+
+Note that:
+
+- Only a single policy can be set, shared by all `render` and `unsafeHTML` calls.
+- You should call `TemplateResult.setCSPTrustedTypesPolicy()` ahead of any other call of `@github/jtml` in your code.
+- Not all browsers [support the trusted types API in JavaScript](https://caniuse.com/mdn-api_trustedtypes). You may want to use the [recommended tinyfill](https://github.com/w3c/trusted-types#tinyfill) to construct a policy without causing issues in other browsers.
diff --git a/src/template-result.ts b/src/template-result.ts
index bf8a666..6b17fc7 100644
--- a/src/template-result.ts
+++ b/src/template-result.ts
@@ -4,6 +4,15 @@ import type {TemplateTypeInit} from '@github/template-parts'
 const templates = new WeakMap<TemplateStringsArray, HTMLTemplateElement>()
 const renderedTemplates = new WeakMap<Node | NodeTemplatePart, HTMLTemplateElement>()
 const renderedTemplateInstances = new WeakMap<Node | NodeTemplatePart, TemplateInstance>()
+
+interface CSPTrustedHTMLToStringable {
+  toString: () => string
+}
+
+interface CSPTrustedTypesPolicy {
+  createHTML: (s: string) => CSPTrustedHTMLToStringable
+}
+
 export class TemplateResult {
   constructor(
     public readonly strings: TemplateStringsArray,
@@ -11,13 +20,21 @@ export class TemplateResult {
     public processor: TemplateTypeInit
   ) {}
 
+  static cspTrustedTypesPolicy: CSPTrustedTypesPolicy | null = null
+
+  static setCSPTrustedTypesPolicy(policy: CSPTrustedTypesPolicy | null) {
+    TemplateResult.cspTrustedTypesPolicy = policy
+  }
+
   get template(): HTMLTemplateElement {
     if (templates.has(this.strings)) {
       return templates.get(this.strings)!
     } else {
       const template = document.createElement('template')
       const end = this.strings.length - 1
-      template.innerHTML = this.strings.reduce((str, cur, i) => str + cur + (i < end ? `{{ ${i} }}` : ''), '')
+      const html = this.strings.reduce((str, cur, i) => str + cur + (i < end ? `{{ ${i} }}` : ''), '')
+      const trustedHtml = (TemplateResult.cspTrustedTypesPolicy?.createHTML(html) as string | undefined) ?? html
+      template.innerHTML = trustedHtml
       templates.set(this.strings, template)
       return template
     }
diff --git a/src/trusted-types.ts b/src/trusted-types.ts
new file mode 100644
index 0000000..e69de29
diff --git a/src/unsafe-html.ts b/src/unsafe-html.ts
index f35f714..ff757b5 100644
--- a/src/unsafe-html.ts
+++ b/src/unsafe-html.ts
@@ -1,11 +1,13 @@
 import {directive} from './directive.js'
 import {NodeTemplatePart} from '@github/template-parts'
 import type {TemplatePart} from '@github/template-parts'
+import {TemplateResult} from './template-result.js'
 
 export const unsafeHTML = directive((value: string) => (part: TemplatePart) => {
   if (!(part instanceof NodeTemplatePart)) return
   const template = document.createElement('template')
-  template.innerHTML = value
+  const trustedValue = (TemplateResult.cspTrustedTypesPolicy?.createHTML(value) as string | undefined) ?? value
+  template.innerHTML = trustedValue
   const fragment = document.importNode(template.content, true)
   part.replace(...fragment.childNodes)
 })
diff --git a/test/render.ts b/test/render.ts
index 1263a93..519e1e1 100644
--- a/test/render.ts
+++ b/test/render.ts
@@ -1,5 +1,5 @@
 import {expect} from 'chai'
-import {html, render} from '../lib/index.js'
+import {html, render, TemplateResult} from '../lib/index.js'
 import type {TemplateResult} from '../lib/index.js'
 
 describe('render', () => {
@@ -8,6 +8,10 @@ describe('render', () => {
     surface = document.createElement('section')
   })
 
+  afterEach(() => {
+    TemplateResult.setCSPTrustedTypesPolicy(null)
+  })
+
   it('memoizes by TemplateResult#template, updating old templates with new values', () => {
     const main = (x: string | null = null) => html`<div class="${x}"></div>`
     render(main('foo'), surface)
@@ -55,4 +59,21 @@ describe('render', () => {
       expect(surface.innerHTML).to.contain('<div><span><div></div></span><span><div></div></span></div>')
     })
   })
+
+  describe('trusted types', () => {
+    it('respects a Trusted Types Policy if it is set', () => {
+      let policyCalled = false
+      const rewrittenFragment = '<div id="bar"></div>'
+      TemplateResult.setCSPTrustedTypesPolicy({
+        createHTML: (_html: string) => {
+          policyCalled = true
+          return rewrittenFragment
+        }
+      })
+      const main = (x: string | null = null) => html`<div class="${x}"></div>`
+      render(main('foo'), surface)
+      expect(surface.innerHTML).to.equal(rewrittenFragment)
+      expect(policyCalled).to.be.true
+    })
+  })
 })
diff --git a/test/trusted-types.ts b/test/trusted-types.ts
new file mode 100644
index 0000000..3045d1f
--- /dev/null
+++ b/test/trusted-types.ts
@@ -0,0 +1,19 @@
+import {expect} from 'chai'
+import {TemplateResult} from '../lib/index.js'
+
+describe('trusted types', () => {
+  after(() => {
+    TemplateResult.setCSPTrustedTypesPolicy(null)
+  })
+
+  it('can set a CSP Trusted Types policy', () => {
+    const dummyPolicy = {
+      createHTML: (htmlText: string) => {
+        return htmlText
+      }
+    }
+    expect(TemplateResult.cspTrustedTypesPolicy).to.equal(null)
+    TemplateResult.setCSPTrustedTypesPolicy(dummyPolicy)
+    expect(TemplateResult.cspTrustedTypesPolicy).to.equal(dummyPolicy)
+  })
+})
diff --git a/test/unsafe-html.ts b/test/unsafe-html.ts
index b17db05..997ff8a 100644
--- a/test/unsafe-html.ts
+++ b/test/unsafe-html.ts
@@ -1,7 +1,13 @@
 import {expect} from 'chai'
-import {html, render, unsafeHTML} from '../lib/index.js'
+import {html, render, TemplateResult, unsafeHTML} from '../lib/index.js'
 
 describe('unsafeHTML', () => {
+  beforeEach(() => {
+    TemplateResult.setCSPTrustedTypesPolicy(null)
+  })
+  afterEach(() => {
+    TemplateResult.setCSPTrustedTypesPolicy(null)
+  })
   it('renders basic text', async () => {
     const surface = document.createElement('section')
     render(html`<div>${unsafeHTML('Hello World')}</div>`, surface)
@@ -31,4 +37,18 @@ describe('unsafeHTML', () => {
     render(fn('<a href="">Universe</a>'), surface)
     expect(surface.innerHTML).to.equal('<div><span>Hello</span><span><a href="">Universe</a></span></div>')
   })
+  it('respects trusted types', async () => {
+    let policyCalled = false
+    const rewrittenFragment = '<div id="bar">This has been rewritten by Trusted Types.</div>'
+    TemplateResult.setCSPTrustedTypesPolicy({
+      createHTML: (_html: string) => {
+        policyCalled = true
+        return rewrittenFragment
+      }
+    })
+    const surface = document.createElement('section')
+    render(html`<div>${unsafeHTML('<span>Hello</span><span>World</span>')}</div>`, surface)
+    expect(surface.innerHTML).to.equal(rewrittenFragment)
+    expect(policyCalled).to.be.true
+  })
 })