diff --git a/pkg/runtime/codegen.go b/pkg/runtime/codegen.go
index dbf6c9d..ecf64fd 100644
--- a/pkg/runtime/codegen.go
+++ b/pkg/runtime/codegen.go
@@ -8,6 +8,7 @@ import (
 	"io"
 	"path/filepath"
 	"reflect"
+	"regexp"
 	"sort"
 	"strings"
 	"time"
@@ -484,6 +485,10 @@ func (g *Generator) generateValue(value any) string {
 	case time.Duration:
 		alias := g.addImportWithAlias("time")
 		return fmt.Sprintf("%s.Duration(%d)", alias, int64(v))
+	case *regexp.Regexp:
+		alias := g.addImportWithAlias("regexp")
+		// Use MustCompile since we know the pattern is valid (it compiled successfully in the reader)
+		return fmt.Sprintf("%s.MustCompile(%#v)", alias, v.String())
 	case *lang.BigDecimal:
 		return g.generateBigDecimalValue(v)
 	case bool:
diff --git a/pkg/runtime/testdata/codegen/test/regex_literal.glj b/pkg/runtime/testdata/codegen/test/regex_literal.glj
new file mode 100644
index 0000000..28628e9
--- /dev/null
+++ b/pkg/runtime/testdata/codegen/test/regex_literal.glj
@@ -0,0 +1,18 @@
+(ns codegen.test.regex-literal)
+
+;; Test regex literal compilation with various patterns
+(def pattern-literal #"[a-z]+")
+
+;; Test with special characters that need escaping
+(def pattern-with-backslash #"\\d+")
+(def pattern-with-quotes #"\"quoted\"")
+(def pattern-with-newline #"line1\nline2")
+(def pattern-complex #"^(?:foo|bar)\s*=\s*(['\"]?)(.+?)$")
+
+;; Test re-pattern function call  
+(def pattern-function (re-pattern "[0-9]+"))
+
+;; Test using the patterns
+(defn test-match [s]
+  (and (re-matches pattern-literal "hello")
+       (re-matches pattern-function "12345")))
\ No newline at end of file
diff --git a/pkg/runtime/testdata/codegen/test/regex_literal/load.go.out b/pkg/runtime/testdata/codegen/test/regex_literal/load.go.out
new file mode 100644
index 0000000..8b33afa
--- /dev/null
+++ b/pkg/runtime/testdata/codegen/test/regex_literal/load.go.out
@@ -0,0 +1,162 @@
+// Code generated by glojure codegen. DO NOT EDIT.
+
+package regex_DASH_literal
+
+import (
+	fmt "fmt"
+	lang "github.com/glojurelang/glojure/pkg/lang"
+	runtime "github.com/glojurelang/glojure/pkg/runtime"
+	reflect "reflect"
+	regexp4 "regexp"
+)
+
+func init() {
+	runtime.RegisterNSLoader("codegen/test/regex_literal", LoadNS)
+}
+
+func checkDerefVar(v *lang.Var) any {
+	if v.IsMacro() {
+		panic(lang.NewIllegalArgumentError(fmt.Sprintf("can't take value of macro: %v", v)))
+	}
+	return v.Get()
+}
+
+func checkArity(args []any, expected int) {
+	if len(args) != expected {
+		panic(lang.NewIllegalArgumentError("wrong number of arguments (" + fmt.Sprint(len(args)) + ")"))
+	}
+}
+
+func checkArityGTE(args []any, min int) {
+	if len(args) < min {
+		panic(lang.NewIllegalArgumentError("wrong number of arguments (" + fmt.Sprint(len(args)) + ")"))
+	}
+}
+
+// LoadNS initializes the namespace "codegen.test.regex-literal"
+func LoadNS() {
+	sym_clojure_DOT_core := lang.NewSymbol("clojure.core")
+	sym_codegen_DOT_test_DOT_regex_DASH_literal := lang.NewSymbol("codegen.test.regex-literal")
+	sym_pattern_DASH_complex := lang.NewSymbol("pattern-complex")
+	sym_pattern_DASH_function := lang.NewSymbol("pattern-function")
+	sym_pattern_DASH_literal := lang.NewSymbol("pattern-literal")
+	sym_pattern_DASH_with_DASH_backslash := lang.NewSymbol("pattern-with-backslash")
+	sym_pattern_DASH_with_DASH_newline := lang.NewSymbol("pattern-with-newline")
+	sym_pattern_DASH_with_DASH_quotes := lang.NewSymbol("pattern-with-quotes")
+	sym_re_DASH_matches := lang.NewSymbol("re-matches")
+	sym_s := lang.NewSymbol("s")
+	sym_test_DASH_match := lang.NewSymbol("test-match")
+	kw_arglists := lang.NewKeyword("arglists")
+	kw_column := lang.NewKeyword("column")
+	kw_end_DASH_column := lang.NewKeyword("end-column")
+	kw_end_DASH_line := lang.NewKeyword("end-line")
+	kw_file := lang.NewKeyword("file")
+	kw_line := lang.NewKeyword("line")
+	kw_ns := lang.NewKeyword("ns")
+	kw_rettag := lang.NewKeyword("rettag")
+	// var clojure.core/re-matches
+	var_clojure_DOT_core_re_DASH_matches := lang.InternVarName(sym_clojure_DOT_core, sym_re_DASH_matches)
+	// var codegen.test.regex-literal/pattern-complex
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_complex := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_complex)
+	// var codegen.test.regex-literal/pattern-function
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_function := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_function)
+	// var codegen.test.regex-literal/pattern-literal
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_literal := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_literal)
+	// var codegen.test.regex-literal/pattern-with-backslash
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_backslash := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_with_DASH_backslash)
+	// var codegen.test.regex-literal/pattern-with-newline
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_newline := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_with_DASH_newline)
+	// var codegen.test.regex-literal/pattern-with-quotes
+	var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_quotes := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_pattern_DASH_with_DASH_quotes)
+	// var codegen.test.regex-literal/test-match
+	var_codegen_DOT_test_DOT_regex_DASH_literal_test_DASH_match := lang.InternVarName(sym_codegen_DOT_test_DOT_regex_DASH_literal, sym_test_DASH_match)
+	// reference fmt to avoid unused import error
+	_ = fmt.Printf
+	// reference reflect to avoid unused import error
+	_ = reflect.TypeOf
+	ns := lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal)
+	_ = ns
+	// pattern-complex
+	{
+		tmp0 := sym_pattern_DASH_complex.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(10), kw_column, int(6), kw_end_DASH_line, int(10), kw_end_DASH_column, int(20), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_complex = ns.InternWithValue(tmp0, regexp4.MustCompile("^(?:foo|bar)\\s*=\\s*(['\\\"]?)(.+?)$"), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_complex.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// pattern-function
+	{
+		tmp0 := sym_pattern_DASH_function.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(13), kw_column, int(6), kw_end_DASH_line, int(13), kw_end_DASH_column, int(21), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_function = ns.InternWithValue(tmp0, regexp4.MustCompile("[0-9]+"), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_function.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// pattern-literal
+	{
+		tmp0 := sym_pattern_DASH_literal.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(4), kw_column, int(6), kw_end_DASH_line, int(4), kw_end_DASH_column, int(20), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_literal = ns.InternWithValue(tmp0, regexp4.MustCompile("[a-z]+"), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_literal.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// pattern-with-backslash
+	{
+		tmp0 := sym_pattern_DASH_with_DASH_backslash.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(7), kw_column, int(6), kw_end_DASH_line, int(7), kw_end_DASH_column, int(27), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_backslash = ns.InternWithValue(tmp0, regexp4.MustCompile("\\\\d+"), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_backslash.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// pattern-with-newline
+	{
+		tmp0 := sym_pattern_DASH_with_DASH_newline.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(9), kw_column, int(6), kw_end_DASH_line, int(9), kw_end_DASH_column, int(25), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_newline = ns.InternWithValue(tmp0, regexp4.MustCompile("line1\\nline2"), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_newline.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// pattern-with-quotes
+	{
+		tmp0 := sym_pattern_DASH_with_DASH_quotes.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(8), kw_column, int(6), kw_end_DASH_line, int(8), kw_end_DASH_column, int(24), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_quotes = ns.InternWithValue(tmp0, regexp4.MustCompile("\\\"quoted\\\""), true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_with_DASH_quotes.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+	// test-match
+	{
+		tmp0 := sym_test_DASH_match.WithMeta(lang.NewMap(kw_file, "codegen/test/regex_literal.glj", kw_line, int(16), kw_column, int(7), kw_end_DASH_line, int(16), kw_end_DASH_column, int(16), kw_arglists, lang.NewList(lang.NewVector(sym_s)), kw_ns, lang.FindOrCreateNamespace(sym_codegen_DOT_test_DOT_regex_DASH_literal))).(*lang.Symbol)
+		var tmp1 lang.FnFunc
+		tmp1 = lang.NewFnFunc(func(args ...any) any {
+			checkArity(args, 1)
+			v2 := args[0]
+			_ = v2
+			var tmp3 any
+			{ // let
+				// let binding "and__0__auto__"
+				tmp4 := checkDerefVar(var_clojure_DOT_core_re_DASH_matches)
+				tmp5 := checkDerefVar(var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_literal)
+				tmp6 := lang.Apply(tmp4, []any{tmp5, "hello"})
+				var v7 any = tmp6
+				_ = v7
+				var tmp8 any
+				if lang.IsTruthy(v7) {
+					tmp9 := checkDerefVar(var_clojure_DOT_core_re_DASH_matches)
+					tmp10 := checkDerefVar(var_codegen_DOT_test_DOT_regex_DASH_literal_pattern_DASH_function)
+					tmp11 := lang.Apply(tmp9, []any{tmp10, "12345"})
+					tmp8 = tmp11
+				} else {
+					tmp8 = v7
+				}
+				tmp3 = tmp8
+			} // end let
+			return tmp3
+		})
+		tmp1 = tmp1.WithMeta(lang.NewMap(kw_rettag, nil)).(lang.FnFunc)
+		var_codegen_DOT_test_DOT_regex_DASH_literal_test_DASH_match = ns.InternWithValue(tmp0, tmp1, true)
+		if tmp0.Meta() != nil {
+			var_codegen_DOT_test_DOT_regex_DASH_literal_test_DASH_match.SetMeta(tmp0.Meta().(lang.IPersistentMap))
+		}
+	}
+}