diff --git a/src/reflect/all_test.go b/src/reflect/all_test.go
index febbd5f5a7849..56d91105a6e0d 100644
--- a/src/reflect/all_test.go
+++ b/src/reflect/all_test.go
@@ -5891,6 +5891,87 @@ func TestStructOfDifferentPkgPath(t *testing.T) {
 	})
 }
 
+func TestStructOfTooLarge(t *testing.T) {
+	t1 := TypeOf(byte(0))
+	t2 := TypeOf(int16(0))
+	t4 := TypeOf(int32(0))
+	t0 := ArrayOf(0, t1)
+
+	// 2^64-3 sized type (or 2^32-3 on 32-bit archs)
+	bigType := StructOf([]StructField{
+		{Name: "F1", Type: ArrayOf(int(^uintptr(0)>>1), t1)},
+		{Name: "F2", Type: ArrayOf(int(^uintptr(0)>>1-1), t1)},
+	})
+
+	type test struct {
+		shouldPanic bool
+		fields      []StructField
+	}
+
+	tests := [...]test{
+		{
+			shouldPanic: false, // 2^64-1, ok
+			fields: []StructField{
+				{Name: "F1", Type: bigType},
+				{Name: "F2", Type: ArrayOf(2, t1)},
+			},
+		},
+		{
+			shouldPanic: true, // overflow in total size
+			fields: []StructField{
+				{Name: "F1", Type: bigType},
+				{Name: "F2", Type: ArrayOf(3, t1)},
+			},
+		},
+		{
+			shouldPanic: true, // overflow while aligning F2
+			fields: []StructField{
+				{Name: "F1", Type: bigType},
+				{Name: "F2", Type: t4},
+			},
+		},
+		{
+			shouldPanic: true, // overflow while adding trailing byte for zero-sized fields
+			fields: []StructField{
+				{Name: "F1", Type: bigType},
+				{Name: "F2", Type: ArrayOf(2, t1)},
+				{Name: "F3", Type: t0},
+			},
+		},
+		{
+			shouldPanic: true, // overflow while aligning total size
+			fields: []StructField{
+				{Name: "F1", Type: t2},
+				{Name: "F2", Type: bigType},
+			},
+		},
+	}
+
+	for i, tt := range tests {
+		func() {
+			defer func() {
+				err := recover()
+				if !tt.shouldPanic {
+					if err != nil {
+						t.Errorf("test %d should not panic, got %s", i, err)
+					}
+					return
+				}
+				if err == nil {
+					t.Errorf("test %d expected to panic", i)
+					return
+				}
+				s := fmt.Sprintf("%s", err)
+				if s != "reflect.StructOf: struct size would exceed virtual address space" {
+					t.Errorf("test %d wrong panic message: %s", i, s)
+					return
+				}
+			}()
+			_ = StructOf(tt.fields)
+		}()
+	}
+}
+
 func TestChanOf(t *testing.T) {
 	// check construction and use of type not in binary
 	type T string
diff --git a/src/reflect/type.go b/src/reflect/type.go
index 7b8cf0ee621aa..fc591eee69cf7 100644
--- a/src/reflect/type.go
+++ b/src/reflect/type.go
@@ -2635,10 +2635,16 @@ func StructOf(fields []StructField) Type {
 		comparable = comparable && (ft.equal != nil)
 
 		offset := align(size, uintptr(ft.align))
+		if offset < size {
+			panic("reflect.StructOf: struct size would exceed virtual address space")
+		}
 		if ft.align > typalign {
 			typalign = ft.align
 		}
 		size = offset + ft.size
+		if size < offset {
+			panic("reflect.StructOf: struct size would exceed virtual address space")
+		}
 		f.offset = offset
 
 		if ft.size == 0 {
@@ -2655,6 +2661,9 @@ func StructOf(fields []StructField) Type {
 		// zero-sized field can't manufacture a pointer to the
 		// next object in the heap. See issue 9401.
 		size++
+		if size == 0 {
+			panic("reflect.StructOf: struct size would exceed virtual address space")
+		}
 	}
 
 	var typ *structType
@@ -2697,7 +2706,11 @@ func StructOf(fields []StructField) Type {
 	str := string(repr)
 
 	// Round the size up to be a multiple of the alignment.
-	size = align(size, uintptr(typalign))
+	s := align(size, uintptr(typalign))
+	if s < size {
+		panic("reflect.StructOf: struct size would exceed virtual address space")
+	}
+	size = s
 
 	// Make the struct type.
 	var istruct any = struct{}{}