diff --git a/conftest.py b/conftest.py
index c8ed6d3..af7de76 100644
--- a/conftest.py
+++ b/conftest.py
@@ -17,4 +17,4 @@
 try:
   app.run(lambda argv: None)
 except SystemExit:
-  pass
\ No newline at end of file
+  pass
diff --git a/xarray_tensorstore.py b/xarray_tensorstore.py
index d1d0803..9743d38 100644
--- a/xarray_tensorstore.py
+++ b/xarray_tensorstore.py
@@ -99,6 +99,18 @@ def __getitem__(self, key: indexing.ExplicitIndexer) -> _TensorStoreAdapter:
     translated = indexed[tensorstore.d[:].translate_to[0]]
     return type(self)(translated)
 
+  def __setitem__(self, key: indexing.ExplicitIndexer, value) -> None:
+    index_tuple = tuple(map(_numpy_to_tensorstore_index, key.tuple, self.shape))
+    if isinstance(key, indexing.OuterIndexer):
+      self.array.oindex[index_tuple] = value
+    elif isinstance(key, indexing.VectorizedIndexer):
+      self.array.vindex[index_tuple] = value
+    else:
+      assert isinstance(key, indexing.BasicIndexer)
+      self.array[index_tuple] = value
+    # Invalidate the future so that the next read will pick up the new value
+    object.__setattr__(self, 'future', None)
+
   # xarray>2024.02.0 uses oindex and vindex properties, which are expected to
   # return objects whose __getitem__ method supports the appropriate form of
   # indexing.
@@ -200,6 +212,7 @@ def open_zarr(
     *,
     context: tensorstore.Context | None = None,
     mask_and_scale: bool = True,
+    write: bool = False,
 ) -> xarray.Dataset:
   """Open an xarray.Dataset from Zarr using TensorStore.
 
@@ -228,6 +241,7 @@ def open_zarr(
     mask_and_scale: if True (default), attempt to apply masking and scaling like
       xarray.open_zarr(). This is only supported for coordinate variables and
       otherwise will raise an error.
+    write: Allow write access. Defaults to False.
 
   Returns:
     Dataset with all data variables opened via TensorStore.
@@ -259,7 +273,7 @@ def open_zarr(
 
   specs = {k: _zarr_spec_from_path(os.path.join(path, k)) for k in ds}
   array_futures = {
-      k: tensorstore.open(spec, read=True, write=False, context=context)
+      k: tensorstore.open(spec, read=True, write=write, context=context)
       for k, spec in specs.items()
   }
   arrays = {k: v.result() for k, v in array_futures.items()}
diff --git a/xarray_tensorstore_test.py b/xarray_tensorstore_test.py
index d6f33dc..c40ab9b 100644
--- a/xarray_tensorstore_test.py
+++ b/xarray_tensorstore_test.py
@@ -1,13 +1,13 @@
 # Copyright 2023 Google LLC
 #
-# Licensed under the Apache License, Version 2.0 (the "License");
+# Licensed under the Apache License, Version 2.0 (the 'License');
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     https://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
+# distributed under the License is distributed on an 'AS IS' BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
@@ -15,8 +15,10 @@
 from absl.testing import parameterized
 import numpy as np
 import pandas as pd
+import pytest
 import tensorstore
 import xarray
+from xarray.core import indexing
 import xarray_tensorstore
 
 
@@ -136,9 +138,7 @@ def test_compute(self):
     self.assertNotIsInstance(computed_data, tensorstore.TensorStore)
 
   def test_open_zarr_from_uri(self):
-    source = xarray.Dataset(
-        {'baz': (('x', 'y', 'z'), np.arange(24).reshape(2, 3, 4))}
-    )
+    source = xarray.Dataset({'baz': (('x', 'y', 'z'), np.arange(24).reshape(2, 3, 4))})
     path = self.create_tempdir().full_path
     source.chunk().to_zarr(path)
 
@@ -221,6 +221,61 @@ def test_mask_and_scale(self):
     xarray.testing.assert_identical(actual, source)
     self.assertEqual(actual.coords['x'].encoding['add_offset'], -1)
 
+  @parameterized.named_parameters(
+      {
+          'testcase_name': 'basic_indexing',
+          'key': (slice(1, None), slice(None), slice(None)),
+          'value': np.full((1, 2, 3), -1),
+      },
+      {
+          'testcase_name': 'outer_indexing',
+          'key': (np.array([0]), np.array([1]), slice(None)),
+          'value': np.full((1, 1, 3), -2),
+      },
+      {
+          'testcase_name': 'vectorized_indexing',
+          'key': (np.array([0]), np.array([0, 1]), slice(None)),
+          'value': np.full((2, 3), -3),
+      },
+  )
+  def test_setitem(self, key, value):
+    source_data = np.array([[[1, 2, 3], [4, 5, 6]], [[7, 8, 9], [10, 11, 12]]])
+    source = xarray.DataArray(
+        source_data,
+        dims=('x', 'y', 'z'),
+        name='baz',
+    )
+    path = self.create_tempdir().full_path
+    source.to_dataset().chunk().to_zarr(path)
+
+    opened = xarray_tensorstore.open_zarr(path, write=True)['baz']
+
+    opened[key] = value
+    read = xarray_tensorstore.read(opened)
+
+    expected_data = source_data.copy()
+    expected_data[key] = value
+    expected = xarray.DataArray(
+        expected_data,
+        dims=('x', 'y', 'z'),
+        name='baz',
+    )
+
+    xarray.testing.assert_equal(read, expected)
+
+  def test_setitem_readonly(self):
+    source = xarray.DataArray(
+        np.array([[[1, 2, 3], [4, 5, 6]], [[7, 8, 9], [10, 11, 12]]]),
+        dims=('x', 'y', 'z'),
+        name='baz',
+    )
+    path = self.create_tempdir().full_path
+    source.to_dataset().chunk().to_zarr(path)
+
+    opened = xarray_tensorstore.open_zarr(path)['baz']
+    with pytest.raises(ValueError):
+      opened[1:, ...] = np.full((1, 2, 3), -1)
+
 
 if __name__ == '__main__':
   absltest.main()