diff --git a/packages/google-cloud-redis/setup.py b/packages/google-cloud-redis/setup.py
index 7f1bd273dd42..24935d8864ee 100644
--- a/packages/google-cloud-redis/setup.py
+++ b/packages/google-cloud-redis/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-redis"
diff --git a/packages/google-cloud-resource-manager/setup.py b/packages/google-cloud-resource-manager/setup.py
index 5220d41e20e3..c25b9ae77872 100644
--- a/packages/google-cloud-resource-manager/setup.py
+++ b/packages/google-cloud-resource-manager/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-retail/setup.py b/packages/google-cloud-retail/setup.py
index af7fcc901682..eb849c3420dc 100644
--- a/packages/google-cloud-retail/setup.py
+++ b/packages/google-cloud-retail/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-retail"
diff --git a/packages/google-cloud-run/setup.py b/packages/google-cloud-run/setup.py
index c90812a1dcce..422e7d47d1e0 100644
--- a/packages/google-cloud-run/setup.py
+++ b/packages/google-cloud-run/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-scheduler/setup.py b/packages/google-cloud-scheduler/setup.py
index ad4cdd7a49f7..de398f3256dc 100644
--- a/packages/google-cloud-scheduler/setup.py
+++ b/packages/google-cloud-scheduler/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-scheduler"
diff --git a/packages/google-cloud-secret-manager/setup.py b/packages/google-cloud-secret-manager/setup.py
index c0792100552a..9b8dbb6c0462 100644
--- a/packages/google-cloud-secret-manager/setup.py
+++ b/packages/google-cloud-secret-manager/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-securesourcemanager/setup.py b/packages/google-cloud-securesourcemanager/setup.py
index 07a3e5458772..c2e0872cdd97 100644
--- a/packages/google-cloud-securesourcemanager/setup.py
+++ b/packages/google-cloud-securesourcemanager/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-securitycenter/setup.py b/packages/google-cloud-securitycenter/setup.py
index 9969e9f53d3b..c9b8947cd273 100644
--- a/packages/google-cloud-securitycenter/setup.py
+++ b/packages/google-cloud-securitycenter/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-securitycentermanagement/setup.py b/packages/google-cloud-securitycentermanagement/setup.py
index 1828df84e4ca..cdb68d1357f0 100644
--- a/packages/google-cloud-securitycentermanagement/setup.py
+++ b/packages/google-cloud-securitycentermanagement/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-service-control/setup.py b/packages/google-cloud-service-control/setup.py
index 6a1ffe077b9b..0c0c0fd5b2a9 100644
--- a/packages/google-cloud-service-control/setup.py
+++ b/packages/google-cloud-service-control/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-control"
diff --git a/packages/google-cloud-service-directory/setup.py b/packages/google-cloud-service-directory/setup.py
index c57396de9767..c0c5343f370e 100644
--- a/packages/google-cloud-service-directory/setup.py
+++ b/packages/google-cloud-service-directory/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-service-management/setup.py b/packages/google-cloud-service-management/setup.py
index 33cb6aeae906..c8c885741111 100644
--- a/packages/google-cloud-service-management/setup.py
+++ b/packages/google-cloud-service-management/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-cloud-service-usage/setup.py b/packages/google-cloud-service-usage/setup.py
index 247968659538..d9d7f3ab7e4b 100644
--- a/packages/google-cloud-service-usage/setup.py
+++ b/packages/google-cloud-service-usage/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-usage"
diff --git a/packages/google-cloud-servicehealth/setup.py b/packages/google-cloud-servicehealth/setup.py
index 2ebadbdebbf9..b1a3a45077c3 100644
--- a/packages/google-cloud-servicehealth/setup.py
+++ b/packages/google-cloud-servicehealth/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-servicehealth"
diff --git a/packages/google-cloud-shell/setup.py b/packages/google-cloud-shell/setup.py
index 734aa78c8cb7..770214fa318e 100644
--- a/packages/google-cloud-shell/setup.py
+++ b/packages/google-cloud-shell/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-shell"
diff --git a/packages/google-cloud-source-context/setup.py b/packages/google-cloud-source-context/setup.py
index 7ff34428a20e..0767adb0a9ce 100644
--- a/packages/google-cloud-source-context/setup.py
+++ b/packages/google-cloud-source-context/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-source-context"
diff --git a/packages/google-cloud-speech/setup.py b/packages/google-cloud-speech/setup.py
index d02f752c2a21..a8aa3b334a7d 100644
--- a/packages/google-cloud-speech/setup.py
+++ b/packages/google-cloud-speech/setup.py
@@ -45,7 +45,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-speech"
diff --git a/packages/google-cloud-storage-control/setup.py b/packages/google-cloud-storage-control/setup.py
index 9f0a848ba1ed..7f933afb7f4b 100644
--- a/packages/google-cloud-storage-control/setup.py
+++ b/packages/google-cloud-storage-control/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storage-control"
diff --git a/packages/google-cloud-storage-transfer/setup.py b/packages/google-cloud-storage-transfer/setup.py
index 93cc7482756f..d9cd72e3325b 100644
--- a/packages/google-cloud-storage-transfer/setup.py
+++ b/packages/google-cloud-storage-transfer/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storage-transfer"
diff --git a/packages/google-cloud-storageinsights/setup.py b/packages/google-cloud-storageinsights/setup.py
index 7b4a770f27c9..b8ce175544c0 100644
--- a/packages/google-cloud-storageinsights/setup.py
+++ b/packages/google-cloud-storageinsights/setup.py
@@ -47,7 +47,7 @@
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "proto-plus >= 1.22.3, <2.0.0",
     "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf>=3.20.2,<6.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.20.2,<7.0.0,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storageinsights"