diff --git a/.github/sync-repo-settings.yaml b/.github/sync-repo-settings.yaml
index 4a9e75a9..2f30ae78 100644
--- a/.github/sync-repo-settings.yaml
+++ b/.github/sync-repo-settings.yaml
@@ -7,6 +7,7 @@ branchProtectionRules:
   requiredStatusCheckContexts:
     - 'style-check'
     - 'docs'
+    - 'lint'
     - 'unit (3.7, cpp)'
     - 'unit (3.7, python)'
     - 'unit (3.7, upb)'
diff --git a/.github/workflows/lint.yml b/.github/workflows/lint.yml
new file mode 100644
index 00000000..08c2b5d0
--- /dev/null
+++ b/.github/workflows/lint.yml
@@ -0,0 +1,22 @@
+on:
+  pull_request:
+    branches:
+      - main
+name: lint
+jobs:
+  lint:
+    runs-on: ubuntu-latest
+    steps:
+    - name: Checkout
+      uses: actions/checkout@v4
+    - name: Setup Python
+      uses: actions/setup-python@v5
+      with:
+        python-version: "3.10"
+    - name: Install nox
+      run: |
+        python -m pip install --upgrade setuptools pip wheel
+        python -m pip install nox
+    - name: Run lint_setup_py
+      run: |
+        nox -s lint_setup_py
diff --git a/README.rst b/README.rst
index 296d803e..16e4fb59 100644
--- a/README.rst
+++ b/README.rst
@@ -16,9 +16,9 @@ largely behave like native Python types.
 Documentation
 -------------
 
-`Documentation`_ is available on Read the Docs.
+`API Documentation`_ is available on Read the Docs.
 
-.. _documentation: https://googleapis.dev/python/proto-plus/latest/
+.. _API Documentation: https://googleapis.dev/python/proto-plus/latest/
 
 .. |pypi| image:: https://img.shields.io/pypi/v/proto-plus.svg
    :target: https://pypi.org/project/proto-plus
diff --git a/noxfile.py b/noxfile.py
index 50307e99..01a65b09 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -161,3 +161,11 @@ def docs(session):
         "docs/",
         "docs/_build/html/",
     )
+
+
+@nox.session(python="3.10")
+def lint_setup_py(session):
+    """Verify that setup.py is valid (including RST check)."""
+
+    session.install("docutils", "Pygments")
+    session.run("python", "setup.py", "check", "--restructuredtext", "--strict")