diff --git a/setup.py b/setup.py
index 4afe003e..b03e9bb2 100644
--- a/setup.py
+++ b/setup.py
@@ -86,12 +86,7 @@ def readme():
         "google-cloud-bigquery>=2.25.2,<4.0.0dev",
         "google-cloud-bigquery-storage>=2.0.0,<3.0.0dev",
         "pyarrow>=3.0.0,<7.0dev",
-        # Temporarily set maximimum sqlalchemy to a known-working version while
-        # we debug failing compliance tests. See:
-        # https://github.com/googleapis/python-bigquery-sqlalchemy/issues/386
-        # and
-        # https://github.com/googleapis/python-bigquery-sqlalchemy/issues/385
-        "sqlalchemy>=1.2.0,<=1.4.27",
+        "sqlalchemy>=1.2.0",
         "future",
     ],
     extras_require=extras,
diff --git a/sqlalchemy_bigquery/base.py b/sqlalchemy_bigquery/base.py
index 3a26b330..32247a45 100644
--- a/sqlalchemy_bigquery/base.py
+++ b/sqlalchemy_bigquery/base.py
@@ -733,6 +733,7 @@ class BigQueryDialect(DefaultDialect):
     supports_default_values = False
     supports_empty_insert = False
     supports_multivalues_insert = True
+    supports_statement_cache = False
     supports_unicode_statements = True
     supports_unicode_binds = True
     supports_native_decimal = True