diff --git a/setup.py b/setup.py
index 4e87b3b84..ead602e12 100644
--- a/setup.py
+++ b/setup.py
@@ -29,20 +29,16 @@
 # 'Development Status :: 5 - Production/Stable'
 release_status = "Development Status :: 5 - Production/Stable"
 dependencies = [
-    "grpcio >= 1.47.0, < 2.0dev",  # https://github.com/googleapis/python-bigquery/issues/1262
-    "grpcio >= 1.49.1, < 2.0dev; python_version>='3.11'",
     # NOTE: Maintainers, please do not require google-api-core>=2.x.x
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
-    "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0, <2.0.0dev",
+    "google-api-core >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
     # NOTE: Maintainers, please do not require google-cloud-core>=2.x.x
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-cloud-core >= 1.6.0, <3.0.0dev",
     "google-resumable-media >= 0.6.0, < 3.0dev",
     "packaging >= 20.0.0",
-    "protobuf>=3.19.5,<5.0.0dev,!=3.20.0,!=3.20.1,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",  # For the legacy proto-based types.
     "python-dateutil >= 2.7.2, <3.0dev",
     "requests >= 2.21.0, < 3.0.0dev",
 ]
@@ -82,6 +78,10 @@
         "opentelemetry-sdk >= 1.1.0",
         "opentelemetry-instrumentation >= 0.20b0",
     ],
+    "bigquery_v2": [
+        "proto-plus >= 1.15.0, <2.0.0dev",
+        "protobuf>=3.19.5,<5.0.0dev,!=3.20.0,!=3.20.1,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",  # For the legacy proto-based types.
+    ],
 }
 
 all_extras = []
diff --git a/tests/unit/test_legacy_types.py b/tests/unit/test_legacy_types.py
index 3f51cc511..3431074fd 100644
--- a/tests/unit/test_legacy_types.py
+++ b/tests/unit/test_legacy_types.py
@@ -13,9 +13,17 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+import pytest
+
 import warnings
 
+try:
+    import proto  # type: ignore
+except ImportError:  # pragma: NO COVER
+    proto = None
+
 
+@pytest.mark.skipif(proto is None, reason="proto is not installed")
 def test_importing_legacy_types_emits_warning():
     with warnings.catch_warnings(record=True) as warned:
         from google.cloud.bigquery_v2 import types  # noqa: F401