diff --git a/setup.py b/setup.py
index d56be9c..09aa8b2 100644
--- a/setup.py
+++ b/setup.py
@@ -30,8 +30,9 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0",
-    "packaging >= 14.3",
+    "proto-plus >= 1.15.0,<2.0.0dev",
+    "packaging >= 14.3,<22.0.0dev",
+    "protobuf<4.0.0dev",
 ]
 
 package_root = os.path.abspath(os.path.dirname(__file__))