diff --git a/setup.py b/setup.py
index f459c578..c96b9cf0 100644
--- a/setup.py
+++ b/setup.py
@@ -47,7 +47,7 @@
         # NOTE: Maintainers, please do not require google-api-core>=2.x.x
         # Until this issue is closed
         # https://github.com/googleapis/google-cloud-python/issues/10566
-        "google-api-core[grpc] >= 1.28.0, <3.0.0dev",
+        "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
         "proto-plus >= 1.15.0",
     ),
     python_requires=">=3.6",
diff --git a/testing/constraints-3.6.txt b/testing/constraints-3.6.txt
index 1e3ec8b6..be5a64f3 100644
--- a/testing/constraints-3.6.txt
+++ b/testing/constraints-3.6.txt
@@ -4,5 +4,5 @@
 # Pin the version to the lower bound.
 # e.g., if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have google-cloud-foo==1.14.0
-google-api-core==1.28.0
+google-api-core==1.31.5
 proto-plus==1.15.0