diff --git a/.github/.OwlBot.lock.yaml b/.github/.OwlBot.lock.yaml
index 757c9dc..1ce6085 100644
--- a/.github/.OwlBot.lock.yaml
+++ b/.github/.OwlBot.lock.yaml
@@ -13,5 +13,5 @@
 # limitations under the License.
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-python:latest
-  digest: sha256:81ed5ecdfc7cac5b699ba4537376f3563f6f04122c4ec9e735d3b3dc1d43dd32
-# created: 2022-05-05T22:08:23.383410683Z
+  digest: sha256:e7bb19d47c13839fe8c147e50e02e8b6cf5da8edd1af8b82208cd6f66cc2829c
+# created: 2022-07-05T18:31:20.838186805Z
diff --git a/.github/sync-repo-settings.yaml b/.github/sync-repo-settings.yaml
index aeb59c1..0012af0 100644
--- a/.github/sync-repo-settings.yaml
+++ b/.github/sync-repo-settings.yaml
@@ -10,7 +10,6 @@ branchProtectionRules:
     - 'cla/google'
     - 'OwlBot Post Processor'
     - 'lint'
-    - 'unit (3.6)'
     - 'unit (3.7)'
     - 'unit (3.8)'
     - 'unit (3.9)'
diff --git a/.github/workflows/unittest.yml b/.github/workflows/unittest.yml
index 7588052..20421ef 100644
--- a/.github/workflows/unittest.yml
+++ b/.github/workflows/unittest.yml
@@ -8,7 +8,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python: ['3.6', '3.7', '3.8', '3.9', '3.10']
+        python: ['3.7', '3.8', '3.9', '3.10']
     steps:
     - name: Checkout
       uses: actions/checkout@v3
diff --git a/.kokoro/continuous/prerelease-deps.cfg b/.kokoro/continuous/prerelease-deps.cfg
new file mode 100644
index 0000000..3595fb4
--- /dev/null
+++ b/.kokoro/continuous/prerelease-deps.cfg
@@ -0,0 +1,7 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+# Only run this nox session.
+env_vars: {
+    key: "NOX_SESSION"
+    value: "prerelease_deps"
+}
diff --git a/.kokoro/presubmit/prerelease-deps.cfg b/.kokoro/presubmit/prerelease-deps.cfg
new file mode 100644
index 0000000..3595fb4
--- /dev/null
+++ b/.kokoro/presubmit/prerelease-deps.cfg
@@ -0,0 +1,7 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+# Only run this nox session.
+env_vars: {
+    key: "NOX_SESSION"
+    value: "prerelease_deps"
+}
diff --git a/.kokoro/samples/python3.6/common.cfg b/.kokoro/samples/python3.6/common.cfg
deleted file mode 100644
index d9833cf..0000000
--- a/.kokoro/samples/python3.6/common.cfg
+++ /dev/null
@@ -1,40 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-# Build logs will be here
-action {
-  define_artifacts {
-    regex: "**/*sponge_log.xml"
-  }
-}
-
-# Specify which tests to run
-env_vars: {
-    key: "RUN_TESTS_SESSION"
-    value: "py-3.6"
-}
-
-# Declare build specific Cloud project.
-env_vars: {
-    key: "BUILD_SPECIFIC_GCLOUD_PROJECT"
-    value: "python-docs-samples-tests-py36"
-}
-
-env_vars: {
-    key: "TRAMPOLINE_BUILD_FILE"
-    value: "github/python-test-utils/.kokoro/test-samples.sh"
-}
-
-# Configure the docker image for kokoro-trampoline.
-env_vars: {
-    key: "TRAMPOLINE_IMAGE"
-    value: "gcr.io/cloud-devrel-kokoro-resources/python-samples-testing-docker"
-}
-
-# Download secrets for samples
-gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/python-docs-samples"
-
-# Download trampoline resources.
-gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/trampoline"
-
-# Use the trampoline script to run in docker.
-build_file: "python-test-utils/.kokoro/trampoline_v2.sh"
\ No newline at end of file
diff --git a/.kokoro/samples/python3.6/continuous.cfg b/.kokoro/samples/python3.6/continuous.cfg
deleted file mode 100644
index 7218af1..0000000
--- a/.kokoro/samples/python3.6/continuous.cfg
+++ /dev/null
@@ -1,7 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
-
diff --git a/.kokoro/samples/python3.6/periodic-head.cfg b/.kokoro/samples/python3.6/periodic-head.cfg
deleted file mode 100644
index a36b71a..0000000
--- a/.kokoro/samples/python3.6/periodic-head.cfg
+++ /dev/null
@@ -1,11 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
-
-env_vars: {
-    key: "TRAMPOLINE_BUILD_FILE"
-    value: "github/python-test-utils/.kokoro/test-samples-against-head.sh"
-}
diff --git a/.kokoro/samples/python3.6/periodic.cfg b/.kokoro/samples/python3.6/periodic.cfg
deleted file mode 100644
index 71cd1e5..0000000
--- a/.kokoro/samples/python3.6/periodic.cfg
+++ /dev/null
@@ -1,6 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "False"
-}
diff --git a/.kokoro/samples/python3.6/presubmit.cfg b/.kokoro/samples/python3.6/presubmit.cfg
deleted file mode 100644
index a1c8d97..0000000
--- a/.kokoro/samples/python3.6/presubmit.cfg
+++ /dev/null
@@ -1,6 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
\ No newline at end of file
diff --git a/.kokoro/test-samples-impl.sh b/.kokoro/test-samples-impl.sh
index 8a324c9..2c6500c 100755
--- a/.kokoro/test-samples-impl.sh
+++ b/.kokoro/test-samples-impl.sh
@@ -33,7 +33,7 @@ export PYTHONUNBUFFERED=1
 env | grep KOKORO
 
 # Install nox
-python3.6 -m pip install --upgrade --quiet nox
+python3.9 -m pip install --upgrade --quiet nox
 
 # Use secrets acessor service account to get secrets
 if [[ -f "${KOKORO_GFILE_DIR}/secrets_viewer_service_account.json" ]]; then
@@ -76,7 +76,7 @@ for file in samples/**/requirements.txt; do
     echo "------------------------------------------------------------"
 
     # Use nox to execute the tests for the project.
-    python3.6 -m nox -s "$RUN_TESTS_SESSION"
+    python3.9 -m nox -s "$RUN_TESTS_SESSION"
     EXIT=$?
 
     # If this is a periodic build, send the test log to the FlakyBot.
diff --git a/README.rst b/README.rst
index b225f1b..f2b25dd 100644
--- a/README.rst
+++ b/README.rst
@@ -4,4 +4,5 @@ Python Test Utils
 
 This is a collection of common tools used in system tests of Python client libraries for Google APIs.
 
-We use `nox <https://nox.readthedocs.io/en/latest/>`__ to instrument our tests. This package is added to each `nox` session as described in each repository's ``noxfile.py``.
\ No newline at end of file
+We use `nox <https://nox.readthedocs.io/en/latest/>`__ to instrument our tests. This package is added to each `nox` session as described in each repository's ``noxfile.py``.
+
diff --git a/noxfile.py b/noxfile.py
index cafd955..b15822c 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -90,7 +90,7 @@ def mypy(session):
     session.run("mypy", "test_utils/", "tests/")
 
 
-@nox.session(python=["3.6", "3.7", "3.8", "3.9", "3.10"])
+@nox.session(python=["3.7", "3.8", "3.9", "3.10"])
 def unit(session):
     constraints_path = str(
         CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
diff --git a/owlbot.py b/owlbot.py
index 638de68..ecc97ca 100644
--- a/owlbot.py
+++ b/owlbot.py
@@ -31,11 +31,12 @@
         "MANIFEST.in",  # no 'google' package
         "noxfile.py",  # noxfile is non-standard
         "docs/**/*",  # no docs to publish
-        ".kokoro/docs/",  
+        ".kokoro/docs/",
         ".kokoro/publish-docs.sh",
         "CONTRIBUTING.rst",
         "renovate.json", # no bundle, ignore test resources
         ".github/workflows/docs.yml", # no docs to publish
+	"README.rst",
     ],
 )
 
diff --git a/scripts/readme-gen/templates/install_deps.tmpl.rst b/scripts/readme-gen/templates/install_deps.tmpl.rst
index 275d649..6f069c6 100644
--- a/scripts/readme-gen/templates/install_deps.tmpl.rst
+++ b/scripts/readme-gen/templates/install_deps.tmpl.rst
@@ -12,7 +12,7 @@ Install Dependencies
    .. _Python Development Environment Setup Guide:
        https://cloud.google.com/python/setup
 
-#. Create a virtualenv. Samples are compatible with Python 3.6+.
+#. Create a virtualenv. Samples are compatible with Python 3.7+.
 
     .. code-block:: bash
 
diff --git a/setup.py b/setup.py
index acc4f0a..1a5375a 100644
--- a/setup.py
+++ b/setup.py
@@ -41,13 +41,12 @@
     platforms="Posix; MacOS X; Windows",
     include_package_data=True,
     install_requires=("google-auth >= 0.4.0", "click>=7.0.0", "packaging>=19.0"),
-    python_requires=">=3.6",
+    python_requires=">=3.7",
     classifiers=[
         "Development Status :: 4 - Beta",
         "Intended Audience :: Developers",
         "Operating System :: OS Independent",
         "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",