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Gorshkov Lab

We are a proteome bioinformatics and mass spectrometry group headed by Mikhail (Mike) Gorshkov.

Since the early 2000s, the Gorshkov lab has been working in the field of liquid chromatography/mass spectrometry (LC-MS) for proteomics as well as development of bioinformatics software. Our main research focus today remains with mass-spectrometry-based proteome analysis, from instrumentation to algorithms and data analysis. We implement our developments into fundamental biology research, including proteogenomics, medicine and biotechnology.

Publications

Check Mikhail's Google Scholar profile.

People

Software

  • pyteomics - a Python library for proteomics data analysis [1], [2]
  • IdentiPy and IdentiPy Server - a proteomic search engine with a web interface [3]
  • Scavager - postsearch validation software using machine learning [4]
  • ms1searchpy - a DirectMS1 proteomics search engine for LC-MS1 spectra [5], [6], [7]
  • AA_stat - postsearch analysis and interpretation for open search results [8], [9]
  • viQC - quality control of bottom-up proteomic experiments [10], [11]
  • Biosaur2 - peptide MS feature detector [12]
  • BioLCCC - a first-priciples theoretical model of peptide separation, suitable for RT prediction in any conditions [13], [14], [15], [16]
  • QRePS - statistical analysis and selection of differentially regulated proteins using various metrics [17]
  • Morley - digital plant morphometry and seed germination analysis [18]
  • IQMMA - improved peptide-level LFQ by combining multiple feature detection algorithms [19]
  • TPP_visualise - GUI for prediction of normalized melting curve behavior for different depths in protein-drug interactions

Contact

Email Mikhail Gorshkov at mike.gorshkov@gmail.com.