> BiocManager::valid() * sessionInfo() R version 3.4.1 (2017-06-30) Platform: x86_64-redhat-linux-gnu (64-bit) Running under: Red Hat Enterprise Linux Matrix products: default BLAS/LAPACK: /usr/lib64/R/lib/libRblas.so locale: [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8 [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8 [7] LC_PAPER=en_US.UTF-8 LC_NAME=C [9] LC_ADDRESS=C LC_TELEPHONE=C [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C attached base packages: [1] stats4 parallel stats graphics grDevices utils datasets [8] methods base other attached packages: [1] bsseq_1.14.0 SummarizedExperiment_1.8.1 [3] DelayedArray_0.4.1 matrixStats_0.55.0 [5] Biobase_2.38.0 GenomicRanges_1.30.3 [7] GenomeInfoDb_1.14.0 IRanges_2.12.0 [9] S4Vectors_0.16.0 BiocGenerics_0.24.0 loaded via a namespace (and not attached): [1] Rcpp_1.0.3 XVector_0.18.0 zlibbioc_1.24.0 [4] munsell_0.5.0 colorspace_1.4-1 lattice_0.20-35 [7] R6_2.4.1 rlang_0.4.5 tools_3.4.1 [10] grid_3.4.1 data.table_1.12.8 R.oo_1.23.0 [13] gtools_3.8.1 permute_0.9-5 lifecycle_0.2.0 [16] Matrix_1.2-10 GenomeInfoDbData_1.0.0 BiocManager_1.30.10 [19] R.utils_2.9.2 bitops_1.0-6 RCurl_1.95-4.12 [22] limma_3.34.9 compiler_3.4.1 R.methodsS3_1.8.0 [25] scales_1.1.0 locfit_1.5-9.1 Bioconductor version '3.6' * 5 packages out-of-date * 0 packages too new create a valid installation with BiocManager::install(c( "digest", "glue", "matrixStats", "RCurl", "XML" ), update = TRUE, ask = FALSE) more details: BiocManager::valid()$too_new, BiocManager::valid()$out_of_date Warning message: 5 packages out-of-date; 0 packages too new