diff --git a/can/interfaces/ics_neovi/neovi_bus.py b/can/interfaces/ics_neovi/neovi_bus.py
index 3df0ccc39..176747ad2 100644
--- a/can/interfaces/ics_neovi/neovi_bus.py
+++ b/can/interfaces/ics_neovi/neovi_bus.py
@@ -11,6 +11,8 @@
 """
 
 import logging
+import os
+import tempfile
 from collections import deque
 
 from can import Message, CanError, BusABC
@@ -28,6 +30,35 @@
     ics = None
 
 
+try:
+    from filelock import FileLock
+except ImportError as ie:
+
+    logger.warning(
+        "Using ICS NeoVi can backend without the "
+        "filelock module installed may cause some issues!: %s",
+        ie,
+    )
+
+    class FileLock:
+        """Dummy file lock that does not actually do anything"""
+
+        def __init__(self, lock_file, timeout=-1):
+            self._lock_file = lock_file
+            self.timeout = timeout
+
+        def __enter__(self):
+            return self
+
+        def __exit__(self, exc_type, exc_val, exc_tb):
+            return None
+
+
+# Use inter-process mutex to prevent concurrent device open.
+# When neoVI server is enabled, there is an issue with concurrent device open.
+open_lock = FileLock(os.path.join(tempfile.gettempdir(), "neovi.lock"))
+
+
 class ICSApiError(CanError):
     """
     Indicates an error with the ICS API.
@@ -122,7 +153,9 @@ def __init__(self, channel, can_filters=None, **kwargs):
         type_filter = kwargs.get("type_filter")
         serial = kwargs.get("serial")
         self.dev = self._find_device(type_filter, serial)
-        ics.open_device(self.dev)
+
+        with open_lock:
+            ics.open_device(self.dev)
 
         if "bitrate" in kwargs:
             for channel in self.channels:
diff --git a/setup.py b/setup.py
index 1918b644b..fb1a4de54 100644
--- a/setup.py
+++ b/setup.py
@@ -24,7 +24,10 @@
     long_description = f.read()
 
 # Dependencies
-extras_require = {"serial": ["pyserial~=3.0"], "neovi": ["python-ics>=2.12"]}
+extras_require = {
+    "serial": ["pyserial~=3.0"],
+    "neovi": ["python-ics>=2.12", "filelock"],
+}
 
 tests_require = [
     "pytest~=4.3",
@@ -90,6 +93,7 @@
         "wrapt~=1.10",
         "aenum",
         'windows-curses;platform_system=="Windows"',
+        "filelock",
     ],
     setup_requires=["pytest-runner"],
     extras_require=extras_require,