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Genetics: Socioeconomic migration is linked to genetic differences in Great Britain

Summary of the study

We conducted a study on the geographic distributions of human DNA differences in Great Britain. Human DNA variation is not randomly distributed across geographic regions. Regional differences in human DNA have been long known to reflect ancestry differences from the distant past (Figure). We investigated the extent to which DNA variants that influence heritable human characteristics also show regional differences. We looked at genetic variation associated with physical health, mental health, substance use, personality, BMI, reproduction, height, and educational attainment.

Useful links

Paper | FAQ | Web app

Data Visualization

This repository gives the code of a web application that allows to interactively explore a few geographical components of the UK Biobank.

Here is a screenshot of one of the multiple viz available in the website: fig1

How to use the application

The best way to use this application is via its online version.

To use this application locally, type in a R console:

library(shiny)
runGitHub("holtzy/UKB_geo_application")

It should install all the requested libraries and launch the application.

Citing

Please cite our Paper in Nature

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A website describing genetic and geographical features in the UK Biobank

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