The Pharmacogenetic allele Frequency (PharmFreq) database is a collated repository and search tool for country-specific pharmacogenetic allele frequency at a global scale. It allows users to explore the ethnogeographic variability of genetically encoded drug response differences and identify outlier populations that might benefit from therapeutic adjustments.
A repository and search tool for worldwide country-specific pharmacogenetic allele frequencies
Polymorphisms in drug metabolizing enzymes, drug transporters, and major histocompatibility complex genes cause significant inter-individual differences in drug efficacy and safety. The pattern and complexity of these variations differ across populations. PharmFreq is a global repository of pharmacogenetic frequency data from over 10 million individuals across hundreds of countries, aggregating data on pharmacogenomic alleles from over 1200 studies. The majority of studies focus on East Asian and European populations. The number of studies per country correlates with population size and GDP, with significant coverage disparities. All data is accessible via an interactive web dashboard at pharmfreq.com, providing a comprehensive resource for exploring pharmacogenetic diversity and guiding research in underrepresented populations.
Note
This repository contains a lightweight version of the code and database files used in our publication. For access to the most recent version of the database and the full web application, please visit www.pharmfreq.com.
- Code: A streamlined version of the shiny app.
- Inital database files.
For detailed documentation and updates and most recent version of the database, refer to the main website linked above.
Please cite the following paper if you use the data, website, or code. The resource is published and can be accessed here:
PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes
DOI: 10.1093/nar/gkae1016.
Mail to Roman Tremmel or open a GitHub issue.