diff --git a/devTools/phpstan-src-baseline.neon b/devTools/phpstan-src-baseline.neon
index 32d534fd9..821901df1 100644
--- a/devTools/phpstan-src-baseline.neon
+++ b/devTools/phpstan-src-baseline.neon
@@ -665,6 +665,11 @@ parameters:
 			count: 1
 			path: ../src/Mutator/ZeroIteration/Foreach_.php
 
+		-
+			message: "#^Parameter \\#1 \\$node \\(PhpParser\\\\Node\\\\Stmt\\\\While_\\) of method Infection\\\\Mutator\\\\ZeroIteration\\\\While_\\:\\:mutate\\(\\) should be contravariant with parameter \\$node \\(PhpParser\\\\Node\\) of method Infection\\\\Mutator\\\\Mutator\\:\\:mutate\\(\\)$#"
+			count: 1
+			path: ../src/Mutator/ZeroIteration/While_.php
+
 		-
 			message: "#^Call to static method Webmozart\\\\Assert\\\\Mixin\\:\\:allIsInstanceOf\\(\\) with array\\<PhpParser\\\\Node\\> and 'PhpParser\\\\\\\\Node' will always evaluate to true\\.$#"
 			count: 1
diff --git a/resources/schema.json b/resources/schema.json
index 2382fad33..726780a9a 100644
--- a/resources/schema.json
+++ b/resources/schema.json
@@ -311,6 +311,7 @@
                 "Spread": { "$ref": "#/definitions/default-mutator-config" },
                 "Foreach_": { "$ref": "#/definitions/default-mutator-config" },
                 "For_": { "$ref": "#/definitions/default-mutator-config" },
+                "While_": { "$ref": "#/definitions/default-mutator-config" },
                 "CastArray": { "$ref": "#/definitions/default-mutator-config" },
                 "CastBool": { "$ref": "#/definitions/default-mutator-config" },
                 "CastFloat": { "$ref": "#/definitions/default-mutator-config" },
diff --git a/src/Mutator/ProfileList.php b/src/Mutator/ProfileList.php
index 9a3b556f7..ae7d8fa45 100644
--- a/src/Mutator/ProfileList.php
+++ b/src/Mutator/ProfileList.php
@@ -191,6 +191,7 @@ final class ProfileList
     public const ZERO_ITERATION_PROFILE = [
         Mutator\ZeroIteration\For_::class,
         Mutator\ZeroIteration\Foreach_::class,
+        Mutator\ZeroIteration\While_::class,
     ];
 
     public const CAST_PROFILE = [
@@ -381,6 +382,7 @@ final class ProfileList
         // Zero Iteration
         'Foreach_' => Mutator\ZeroIteration\Foreach_::class,
         'For_' => Mutator\ZeroIteration\For_::class,
+        'While_' => Mutator\ZeroIteration\While_::class,
 
         // Cast
         'CastArray' => Mutator\Cast\CastArray::class,
diff --git a/src/Mutator/ZeroIteration/While_.php b/src/Mutator/ZeroIteration/While_.php
new file mode 100644
index 000000000..2e79e9a46
--- /dev/null
+++ b/src/Mutator/ZeroIteration/While_.php
@@ -0,0 +1,102 @@
+<?php
+/**
+ * This code is licensed under the BSD 3-Clause License.
+ *
+ * Copyright (c) 2017, Maks Rafalko
+ * All rights reserved.
+ *
+ * Redistribution and use in source and binary forms, with or without
+ * modification, are permitted provided that the following conditions are met:
+ *
+ * * Redistributions of source code must retain the above copyright notice, this
+ *   list of conditions and the following disclaimer.
+ *
+ * * Redistributions in binary form must reproduce the above copyright notice,
+ *   this list of conditions and the following disclaimer in the documentation
+ *   and/or other materials provided with the distribution.
+ *
+ * * Neither the name of the copyright holder nor the names of its
+ *   contributors may be used to endorse or promote products derived from
+ *   this software without specific prior written permission.
+ *
+ * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
+ * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+ * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
+ * DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE
+ * FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
+ * DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
+ * SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
+ * CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
+ * OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
+ * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+ */
+
+declare(strict_types=1);
+
+namespace Infection\Mutator\ZeroIteration;
+
+use Infection\Mutator\Definition;
+use Infection\Mutator\GetMutatorName;
+use Infection\Mutator\Mutator;
+use Infection\Mutator\MutatorCategory;
+use PhpParser\Node;
+
+/**
+ * @internal
+ */
+final class While_ implements Mutator
+{
+    use GetMutatorName;
+
+    public static function getDefinition(): ?Definition
+    {
+        return new Definition(
+            <<<'TXT'
+Replaces the iterable being iterated over with a `while` expression with false, preventing
+any iteration within the block to be executed. For example:
+
+```php`
+
+$condition = true;
+while ($condition) {
+    // ...
+}
+```
+
+Will be mutated to:
+
+```php
+
+$condition = true;
+while (false) {
+    // ...
+}
+```
+TXT
+            ,
+            MutatorCategory::SEMANTIC_REDUCTION,
+            null
+        );
+    }
+
+    /**
+     * @psalm-mutation-free
+     *
+     * @param Node\Stmt\While_ $node
+     *
+     * @return iterable<Node\Stmt\While_>
+     */
+    public function mutate(Node $node): iterable
+    {
+        yield new Node\Stmt\While_(
+            new Node\Expr\ConstFetch(new Node\Name('false')),
+            $node->stmts,
+            $node->getAttributes()
+        );
+    }
+
+    public function canMutate(Node $node): bool
+    {
+        return $node instanceof Node\Stmt\While_;
+    }
+}
diff --git a/tests/phpunit/Mutator/ZeroIteration/While_Test.php b/tests/phpunit/Mutator/ZeroIteration/While_Test.php
new file mode 100644
index 000000000..5903c06a8
--- /dev/null
+++ b/tests/phpunit/Mutator/ZeroIteration/While_Test.php
@@ -0,0 +1,102 @@
+<?php
+/**
+ * This code is licensed under the BSD 3-Clause License.
+ *
+ * Copyright (c) 2017, Maks Rafalko
+ * All rights reserved.
+ *
+ * Redistribution and use in source and binary forms, with or without
+ * modification, are permitted provided that the following conditions are met:
+ *
+ * * Redistributions of source code must retain the above copyright notice, this
+ *   list of conditions and the following disclaimer.
+ *
+ * * Redistributions in binary form must reproduce the above copyright notice,
+ *   this list of conditions and the following disclaimer in the documentation
+ *   and/or other materials provided with the distribution.
+ *
+ * * Neither the name of the copyright holder nor the names of its
+ *   contributors may be used to endorse or promote products derived from
+ *   this software without specific prior written permission.
+ *
+ * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
+ * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+ * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
+ * DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE
+ * FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
+ * DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
+ * SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
+ * CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
+ * OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
+ * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+ */
+
+declare(strict_types=1);
+
+namespace Infection\Tests\Mutator\ZeroIteration;
+
+use Infection\Tests\Mutator\BaseMutatorTestCase;
+
+final class While_Test extends BaseMutatorTestCase
+{
+    /**
+     * @dataProvider mutationsProvider
+     *
+     * @param string|string[] $expected
+     */
+    public function test_it_can_mutate(string $input, $expected = []): void
+    {
+        $this->doTest($input, $expected);
+    }
+
+    public function mutationsProvider(): iterable
+    {
+        yield 'It mutates expression part from variable to false' => [
+            <<<'PHP'
+<?php
+
+$condition = true;
+
+while ($condition) {
+}
+
+PHP
+            ,
+            <<<'PHP'
+<?php
+
+$condition = true;
+while (false) {
+}
+PHP
+        ];
+
+        yield 'It mutates expression part from boolean true to false' => [
+            <<<'PHP'
+<?php
+
+while (true) {
+}
+
+PHP
+            ,
+            <<<'PHP'
+<?php
+
+while (false) {
+}
+PHP
+        ];
+
+        yield 'It does not mutate expression part in do-while loop to false' => [
+            <<<'PHP'
+<?php
+
+do {
+
+} while (true);
+
+PHP
+        ];
+    }
+}