diff --git a/setup.py b/setup.py
index ea99eeff..22440d0f 100644
--- a/setup.py
+++ b/setup.py
@@ -66,7 +66,7 @@ def check_setuptools():
                         'opentracing>=2.3.0',
                         'requests>=2.6.0',
                         'six>=1.12.0',
-                        'urllib3<1.27,>=1.21.1'],
+                        'urllib3<1.27,>=1.26.5'],
       entry_points={
                     'instana':  ['string = instana:load'],
                     'flask':    ['string = instana:load'],  # deprecated: use same as 'instana'
diff --git a/tests/requirements-27.txt b/tests/requirements-27.txt
index 13156be5..327eab49 100644
--- a/tests/requirements-27.txt
+++ b/tests/requirements-27.txt
@@ -32,4 +32,4 @@ spyne>=2.9,<=2.12.14
 suds-jurko>=0.6
 tornado>=4.5.3,<6.0
 uvicorn>=0.12.2;python_version>="3.6"
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements-310.txt b/tests/requirements-310.txt
index 7c1d4bc5..b524ca90 100644
--- a/tests/requirements-310.txt
+++ b/tests/requirements-310.txt
@@ -41,4 +41,4 @@ spyne>=2.13.16
 suds-jurko>=0.6
 
 uvicorn>=0.13.4
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements-asynqp-legacy-flask-markupsafe.txt b/tests/requirements-asynqp-legacy-flask-markupsafe.txt
index 40094aa8..792f4f36 100644
--- a/tests/requirements-asynqp-legacy-flask-markupsafe.txt
+++ b/tests/requirements-asynqp-legacy-flask-markupsafe.txt
@@ -13,4 +13,4 @@ markupsafe==2.0.1
 mock>=2.0.0
 nose>=1.0
 pytest>=4.6
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements-asynqp.txt b/tests/requirements-asynqp.txt
index 4aca73ec..b4e53603 100644
--- a/tests/requirements-asynqp.txt
+++ b/tests/requirements-asynqp.txt
@@ -4,4 +4,4 @@ flask>=2.0.0,<3.0.0
 mock>=2.0.0
 nose>=1.0
 pytest>=4.6
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements-cassandra.txt b/tests/requirements-cassandra.txt
index 1b6f7468..ec211da9 100644
--- a/tests/requirements-cassandra.txt
+++ b/tests/requirements-cassandra.txt
@@ -2,4 +2,4 @@ cassandra-driver>=3.20.2
 mock>=2.0.0
 nose>=1.0
 pytest>=4.6
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
\ No newline at end of file
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements-gevent.txt b/tests/requirements-gevent.txt
index 4149115e..2e966894 100644
--- a/tests/requirements-gevent.txt
+++ b/tests/requirements-gevent.txt
@@ -4,4 +4,4 @@ mock>=2.0.0
 nose>=1.0
 pyramid>=1.2
 pytest>=4.6
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
\ No newline at end of file
+urllib3[secure]<1.27,>=1.26.5
diff --git a/tests/requirements.txt b/tests/requirements.txt
index c38c1441..bb0185b1 100644
--- a/tests/requirements.txt
+++ b/tests/requirements.txt
@@ -29,4 +29,4 @@ spyne>=2.13.16
 suds-jurko>=0.6
 tornado>=4.5.3,<6.0
 uvicorn>=0.13.4
-urllib3[secure]!=1.25.0,!=1.25.1,<1.27,>=1.21.1
+urllib3[secure]<1.27,>=1.26.5