Toward Capturing the Exposome: Exposure Biomarker Variability and Co-Exposure Patterns in the Shared Environment
Submitted for peer review, Fall 2017
- Ming Kei (Jake) Chung
- Kurunthachalam Kannan
- email: kurunthachalam[dot]kannan[at]health[dot]ny[dot]gov
- Germaine M. Buck Louis
- email: louisg[at]mail[dot]nih[dot]gov
- Chirag J. Patel
Along with time, variation in the exposome is dependent on the location and sex of study participants. One specific factor that may influence exposure co-variations is a shared household environment.
To examine the influence of shared household and partner’s sex in relation to the variation in 128 endocrine disrupting chemical (EDC) exposures among couples.
In a cohort comprising 501 couples trying for pregnancy, we measured 128 (13 chemical classes) persistent and non persistent EDCs and estimated 1) sex-specific differences; 2) variance explained by shared household; and 3) Spearman's rank correlation coefficients (rs) for females, males, and couples.
- This github repository analytical materials for characterzing the correlations in 501 subjects recruited in the LIFE Study.
- Code for data clean-up, processing, analysis, and visulization can be found on GitHub
- Main findings of our study can be found here
- Preprint paper can be downloaded from BioRxiv
- Please contact us for further information, thank you.