diff --git a/jetty-server/src/main/java/org/eclipse/jetty/server/handler/gzip/GzipHandler.java b/jetty-server/src/main/java/org/eclipse/jetty/server/handler/gzip/GzipHandler.java
index d7ced5a535a2..8dbb2da526a9 100644
--- a/jetty-server/src/main/java/org/eclipse/jetty/server/handler/gzip/GzipHandler.java
+++ b/jetty-server/src/main/java/org/eclipse/jetty/server/handler/gzip/GzipHandler.java
@@ -616,6 +616,9 @@ public void setInflateBufferSize(int size)
     @Override
     public void handle(String target, Request baseRequest, HttpServletRequest request, HttpServletResponse response) throws IOException, ServletException
     {
+        if (response.isCommitted() || baseRequest.isHandled())
+            return;
+
         ServletContext context = baseRequest.getServletContext();
         String path = context == null ? baseRequest.getRequestURI() : URIUtil.addPaths(baseRequest.getServletPath(), baseRequest.getPathInfo());
         LOG.debug("{} handle {} in {}", this, baseRequest, context);
diff --git a/jetty-servlet/src/test/java/org/eclipse/jetty/servlet/GzipHandlerIsHandledTest.java b/jetty-servlet/src/test/java/org/eclipse/jetty/servlet/GzipHandlerIsHandledTest.java
new file mode 100644
index 000000000000..924c8e30cc62
--- /dev/null
+++ b/jetty-servlet/src/test/java/org/eclipse/jetty/servlet/GzipHandlerIsHandledTest.java
@@ -0,0 +1,122 @@
+//
+//  ========================================================================
+//  Copyright (c) 1995-2022 Mort Bay Consulting Pty Ltd and others.
+//  ------------------------------------------------------------------------
+//  All rights reserved. This program and the accompanying materials
+//  are made available under the terms of the Eclipse Public License v1.0
+//  and Apache License v2.0 which accompanies this distribution.
+//
+//      The Eclipse Public License is available at
+//      http://www.eclipse.org/legal/epl-v10.html
+//
+//      The Apache License v2.0 is available at
+//      http://www.opensource.org/licenses/apache2.0.php
+//
+//  You may elect to redistribute this code under either of these licenses.
+//  ========================================================================
+//
+
+package org.eclipse.jetty.servlet;
+
+import java.io.IOException;
+import java.util.concurrent.ExecutionException;
+import java.util.concurrent.LinkedBlockingQueue;
+import java.util.concurrent.TimeoutException;
+import javax.servlet.ServletException;
+import javax.servlet.http.HttpServletRequest;
+import javax.servlet.http.HttpServletResponse;
+
+import org.eclipse.jetty.client.HttpClient;
+import org.eclipse.jetty.client.api.ContentResponse;
+import org.eclipse.jetty.server.Handler;
+import org.eclipse.jetty.server.Request;
+import org.eclipse.jetty.server.Server;
+import org.eclipse.jetty.server.ServerConnector;
+import org.eclipse.jetty.server.handler.AbstractHandler;
+import org.eclipse.jetty.server.handler.DefaultHandler;
+import org.eclipse.jetty.server.handler.HandlerCollection;
+import org.eclipse.jetty.server.handler.ResourceHandler;
+import org.eclipse.jetty.server.handler.gzip.GzipHandler;
+import org.eclipse.jetty.toolchain.test.jupiter.WorkDir;
+import org.eclipse.jetty.util.component.LifeCycle;
+import org.eclipse.jetty.util.resource.PathResource;
+import org.junit.jupiter.api.AfterEach;
+import org.junit.jupiter.api.BeforeEach;
+import org.junit.jupiter.api.Test;
+
+import static org.hamcrest.MatcherAssert.assertThat;
+import static org.hamcrest.Matchers.containsString;
+import static org.hamcrest.Matchers.is;
+
+public class GzipHandlerIsHandledTest
+{
+    public WorkDir workDir;
+
+    private Server server;
+    private HttpClient client;
+    public LinkedBlockingQueue<String> events = new LinkedBlockingQueue<>();
+
+    @BeforeEach
+    public void setUp() throws Exception
+    {
+        server = new Server();
+        ServerConnector connector = new ServerConnector(server);
+        connector.setPort(0);
+        server.addConnector(connector);
+
+        HandlerCollection handlers = new HandlerCollection();
+
+        ResourceHandler resourceHandler = new ResourceHandler();
+        resourceHandler.setBaseResource(new PathResource(workDir.getPath()));
+        resourceHandler.setDirectoriesListed(true);
+        resourceHandler.setHandler(new EventHandler(events, "ResourceHandler"));
+
+        GzipHandler gzipHandler = new GzipHandler();
+        gzipHandler.setMinGzipSize(32);
+        gzipHandler.setHandler(new EventHandler(events, "GzipHandler"));
+
+        handlers.setHandlers(new Handler[]{resourceHandler, gzipHandler, new DefaultHandler()});
+
+        server.setHandler(handlers);
+        server.start();
+
+        client = new HttpClient();
+        client.start();
+    }
+
+    @AfterEach
+    public void tearDown()
+    {
+        LifeCycle.stop(client);
+        LifeCycle.stop(server);
+    }
+
+    @Test
+    public void testRequest() throws ExecutionException, InterruptedException, TimeoutException
+    {
+        ContentResponse response = client.GET(server.getURI().resolve("/"));
+        assertThat("response.status", response.getStatus(), is(200));
+        // we should have received a directory listing from the ResourceHandler
+        assertThat("response.content", response.getContentAsString(), containsString("Directory: /"));
+        // resource handler should have handled the request, meaning no other handlers should have handled it, nor any wrapped handlers
+        assertThat("No events should have been recorded", events.size(), is(0));
+    }
+
+    private static class EventHandler extends AbstractHandler
+    {
+        private final LinkedBlockingQueue<String> events;
+        private final String action;
+
+        public EventHandler(LinkedBlockingQueue<String> events, String action)
+        {
+            this.events = events;
+            this.action = action;
+        }
+
+        @Override
+        public void handle(String target, Request baseRequest, HttpServletRequest request, HttpServletResponse response) throws IOException, ServletException
+        {
+            events.offer(action);
+        }
+    }
+}