Jaime Huerta-Cepas edited this page Oct 17, 2017 · 23 revisions


eggnog-mapper is a tool for fast functional annotation of novel sequences. It uses precomputed orthologous groups and phylogenies from the eggNOG database to transfer functional information from fine-grained orthologs only. Common uses of eggNOG-mapper include the annotation of novel genomes, transcriptomes or even metagenomic gene catalogs.

The use of orthology predictions for functional annotation permits a higher precision than traditional homology searches (i.e. BLAST searches), as it avoids transferring annotations from close paralogs (duplicate genes with a higher chance of being involved in functional divergence).

Benchmarks comparing different eggNOG-mapper options against BLAST and InterProScan are available here.

EggNOG-mapper is also available as a public online resource: http://eggnog-mapper.embl.de


(TOC is shown in the sidebar at right)


[1] Fast genome-wide functional annotation through orthology assignment by
      eggNOG-mapper. Jaime Huerta-Cepas, Damian Szklarczyk, Lars Juhl Jensen,
      Christian von Mering and Peer Bork. Submitted (2016).

[2] eggNOG 4.5: a hierarchical orthology framework with improved functional
      annotations for eukaryotic, prokaryotic and viral sequences. Jaime
      Huerta-Cepas, Damian Szklarczyk, Kristoffer Forslund, Helen Cook, Davide
      Heller, Mathias C. Walter, Thomas Rattei, Daniel R. Mende, Shinichi
      Sunagawa, Michael Kuhn, Lars Juhl Jensen, Christian von Mering, and Peer
      Bork. Nucl. Acids Res. (04 January 2016) 44 (D1): D286-D293. doi: