medianeffect

Dose-Effect Analysis with the Median Effect Principle

The aim of the medianeffect package is to facilitate single and multiple drug dose-effect analysis via the Median Effect Principle, including quantitation of synergism and antagonism in drug combinations.

This work is neither approved nor endorsed by Dr. Ting-Chao Chou, the developer of this analytic approach.

Installation

# Install from GitHub:
devtools::install_github("jhchou/medianeffect", build_vignettes = TRUE)

Example usage

A package vignette provides a detailed example of most functionality and includes some technical background.

# View package vignette
vignette('medianeffect')

Functions

Object generation

• drug_effects() Drug effects object generator, either single drug or constant ratio combination
• ncr_drug_effects() Non-constant ratio drug effects object generator

Calculators

• calc_ci() Calculate combination index (CI)
• calc_dri() Calculate dose reduction index (DRI)
• ncr_calc_ci() Calculate combination index (CI) for non-constant ratio

Plots

• median_effect_plot() Generate Median-Effect Plot
• dose_effect_plot() Generate Dose-Effect Plot
• fa_ci_plot() Generate fa-CI Plot
• fa_dri_plot() Generate fa-DRI Plot
• isobologram_plot() Generate isobologram plot

Methods

• print.drug_effects() Print method for objects of drug_effects class
• print.ncr_drug_effects() Print method for non-constant ratio drug_effects class

Internal helper functions

• calc_d() Calculate predicted doses
• calc_fa() Calculate predicted fraction affected (fa)
• calc_combo() Drug combination calculations
• drug_combo_decompose() Function to decompose a drug_combo drug effects object into its component drug doses