operons definition log2foldchange coverage pvalue orthologies pathways KO00025 virulence 1.76428011136364 0.363636363636364 0.1427234 K03194 K03195 K03196 K03197 K03198 K03199 K03200 K03201 K03202 K03203 K03204 map03070: Bacterial secretion system KO00043 KO09922 KO10283 KO10599 KO10945 cbb3 cytochrome oxidase -0.939940283675 0.5 0.1678609 K00404 K00405 K00406 K00407 map00190: Oxidative phosphorylation; map02020: Two-component system KO00077 two-component system, NarL family, response regulator DesR; sensor histidine kinase DesK 1.74566818755 1 0.03665871 K07693 K07778 map02020: Two-component system KO00082 6-phospho-beta-glucosidase; PTS system, cellobiose-specific IIA component; IIB component; IIC component -1.548826912075 0.5 0.1678609 K01222 K02759 K02760 K02761 KO00207 AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase; methylated-DNA-[protein]-cysteine S-methyltransferase -1.2901730326 0.5 0.3463488 K13530 K13531 KO00208 antagonist of KipI; inhibitor of KinA -0.7412646772 0.5 0.3463488 K06350 K06351 KO00268 assimilatory nitrate reductase catalytic subunit; nitrite reductase (NADH) large subunit -0.7337205611 0.5 0.3463488 K00362 K00372 map00910: Nitrogen metabolism KO00274 KO06931 teichoic acid transport system ATP-binding protein; permease protein -0.82161468505 0.5 0.3463488 K09692 K09693 map02010: ABC transporters KO00390 GntR family transcriptional regulator, trehalose operon transcriptional repressor; trehalose-6-phosphate hydrolase -3.27424759625 1 0.03665871 K01226 K03486 KO00393 two-component system, OmpR family, response regulator VicR; sensor histidine kinase VicK -1.6806579294 1 0.03665871 K07652 K07668 map02020: Two-component system KO00731 large subunit GTPase 1; ribosomal protein L27e 1.93130961475 1 0.03665871 K02901 K14539 KO00733 large subunit ribosomal protein L27Ae; LP1 1.97715284995 1 0.03665871 K02900 K02942 map03010: Ribosome KO00734 prohibitin 1; translation initiation factor 2 subunit 1 1.7053079327 1 0.03665871 K03237 K17080 KO00737 ATP-dependent RNA helicase DDX10/DBP4; U3 small nucleolar RNA-associated protein 15; translation initiation factor 3 subunit I 1.5457639281 0.666666666666667 0.09594705 K03246 K14549 K14776 KO00743 actin-related protein 3; dynactin 5 1.624757153 1 0.03665871 K10427 K18584 KO00757 phosphoglycerate kinase; ubiquinone biosynthesis protein COQ4 1.2720015536 0.5 0.3463488 K00927 K18586 KO00768 60S ribosome subunit biogenesis protein NIP7; cell division control protein 6 1.13779085705 0.5 0.3463488 K02213 K07565 KO00781 nuclear pore complex protein Nup160; structure-specific endonuclease subunit SLX1 0.78953187135 0.5 0.3463488 K14303 K15078 KO00800 STIP1 homology and U-box containing protein 1; mitochondrial import inner membrane translocase subunit TIM44 0.76098257545 0.5 0.3463488 K09561 K17804 KO00851 elongation factor 1 alpha-like protein; small subunit ribosomal protein S15 0.6796069681 0.5 0.3463488 K02956 K14416 KO00873 protein LTV1; translation initiation factor 3 subunit C 1.19815153825 1 0.03665871 K03252 K14798 KO00895 farnesyl diphosphate synthase; histone deacetylase 1/2; protein mago nashi 1.79406060903333 0.666666666666667 0.09594705 K00787 K06067 K12877 KO00904 small nuclear ribonucleoprotein B and B' 1.10431470025 0.5 0.3463488 K06942 K11086 KO00906 lysine-specific histone demethylase 1; translation initiation factor 3 subunit J 1.0106146745 0.5 0.3463488 K03245 K11450 KO00924 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; protein kinase A 1.00130633315 0.5 0.3463488 K01139 K04345 KO00944 DNA-directed RNA polymerase II subunit RPB7; signal peptidase, endoplasmic reticulum-type 1.0166040724 0.5 0.3463488 K03015 K13280 KO00978 large subunit ribosomal protein L41; protein DJ-1; solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 0.9472111625 0.333333333333333 0.4715497 K05687 K15104 K17422 KO00988 CDK-activating kinase assembly factor MAT1; transportin-3 0.94303698385 0.5 0.3463488 K10842 K15436 KO01004 pre-rRNA-processing protein TSR1; staphylococcal nuclease domain-containing protein 1 1.26067968465 1 0.03665871 K14799 K15979 KO01008 20S proteasome subunit beta 3; sentrin-specific protease 7 1.25210042695 0.5 0.3463488 K02735 K08596 KO01060 A1 cistron-splicing factor AAR2; large subunit ribosomal protein L10e 1.2082362363 0.5 0.3463488 K02866 K13205 KO01061 ADP-ribosylation factor-like protein 2; translation initiation factor 3 subunit G 1.3652369391 0.5 0.3463488 K03248 K07943 KO01069 translation initiation factor eIF-2B subunit epsilon; ubiquitin-protein ligase E3 C 1.0702305104 0.5 0.3463488 K03240 K10589 KO01090 RNA-binding protein PNO1; U3 small nucleolar RNA-associated protein 13 1.3614002027 0.5 0.3463488 K11884 K14555 KO01094 FAD synthetase; phospholipase A-2-activating protein 0.94708946415 0.5 0.3463488 K00953 K14018 KO01108 diphthine synthase; phosphatidylinositol glycan, class M 1.4464480865 0.5 0.3463488 K00586 K05284 KO01123 peptidyl-prolyl cis-trans isomerase SDCCAG10; triosephosphate isomerase (TIM) 0.77090708265 0.5 0.3463488 K01803 K12737 KO01128 CDP-diacylglycerol--inositol 3-phosphatidyltransferase; pre-mRNA-splicing helicase BRR2 1.62183959375 1 0.03665871 K00999 K12854 KO01161 nucleolar complex protein 2; tuftelin-interacting protein 11 0.8799352977 0.5 0.3463488 K13103 K14833 KO01166 5'-3' exoribonuclease 2; large subunit ribosomal protein L37Ae 1.49955657545 1 0.03665871 K02921 K12619 KO01191 ATP-dependent DNA helicase Q1; actin related protein 2/3 complex, subunit 2; exosome complex component MTR3 1.494361095 0.666666666666667 0.09594705 K05758 K10899 K12587 KO01193 Ras-related protein Rab-18; splicing factor U2AF 65 kDa subunit 1.1903297413 1 0.03665871 K07910 K12837 KO01204 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8; homeobox protein cut-like 1.5744700791 1 0.03665871 K03952 K09313 KO01208 AdoMet-dependent rRNA methyltransferase SPB1; small subunit ribosomal protein S27Ae 1.61703327245 1 0.03665871 K02977 K14857 KO01215 molecular chaperone GrpE; serine/threonine-protein phosphatase 6 catalytic subunit 0.835387046 0.5 0.3463488 K03687 K15498 KO01218 peptidylprolyl isomerase; protein disulfide-isomerase A1 0.67758544805 0.5 0.3463488 K01802 K09580 KO01225 U3 small nucleolar RNA-associated protein 11; leucyl-tRNA synthetase; solute carrier family 25, member 39/40 0.832856497833333 0.333333333333333 0.4715497 K01869 K14769 K15119 KO01243 COX assembly mitochondrial protein 2; aarF domain-containing kinase 1.15012133215 0.5 0.3463488 K08869 K18172 KO01247 DNA-directed RNA polymerases I, II, and III subunit RPABC3; amyloid beta precursor protein binding protein 1; arginyl-tRNA synthetase; cob(I)alamin adenosyltransferase; histone-lysine N-methyltransferase SETD1 0.83664307616 0.4 0.2453951 K00798 K01887 K03016 K04532 K11422 KO01264 3-hydroxyisobutyryl-CoA hydrolase; DNA-directed RNA polymerase III subunit RPC2 1.2629453559 0.5 0.3463488 K03021 K05605 KO01272 ADP-ribosylation factor 1; RNA-binding protein 26 0.9039340176 0.5 0.3463488 K07937 K13192 KO01273 ATP-dependent RNA helicase DDX23/PRP28; T-complex protein 1 subunit zeta 1.57655922 1 0.03665871 K09498 K12858 KO01281 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9; pre-60S factor REI1; protein MAK16; transcriptional repressor NF-X1 1.5392504089 0.75 0.02403318 K03965 K12236 K14816 K14831 KO01286 F-box and leucine-rich repeat protein 10/11; beta-1,4-mannosyltransferase 1.17503639165 0.5 0.3463488 K03842 K10276 KO01291 4-hydroxybenzoate polyprenyltransferase; essential nuclear protein 1; translation initiation factor 4A 1.5242685771 1 0.007014544 K03257 K06125 K14797 KO01304 ATP-dependent RNA helicase DDX51/DBP6; metaxin 1.01589141385 0.5 0.3463488 K14807 K17776 KO01318 regulator of Ty1 transposition protein 103 1.16231222615 0.5 0.3463488 K06944 K15559 KO01322 F-type H+-transporting ATPase subunit epsilon; kinesin family member 5 1.65115611975 1 0.03665871 K02135 K10396 KO01327 26S proteasome regulatory subunit N3; large subunit ribosomal protein L32 0.8228969368 0.5 0.3463488 K02911 K03033 KO01349 DNA-directed RNA polymerases I and III subunit RPAC2; tubulin gamma; ubiquitin-conjugating enzyme E2 G1 2.06273146046667 1 0.007014544 K03020 K10389 K10575 KO01356 ADP-ribosylation factor-like protein 5B; PAB-dependent poly(A)-specific ribonuclease subunit 3 1.3290114312 0.5 0.3463488 K07950 K12572 KO01363 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 7; vacuolar protein sorting-associated protein 29 1.47463988985 0.5 0.3463488 K18164 K18467 KO01378 protein FAM32A; stromal membrane-associated protein; tubulin beta 1.46413729036667 1 0.007014544 K07375 K12486 K13120 KO01383 H/ACA ribonucleoprotein complex subunit 2; exosome complex component CSL4 1.6741967773 1 0.03665871 K07573 K11129 KO01393 CCR4-NOT transcription complex subunit 7/8; bud site selection protein 20 1.42317196905 1 0.03665871 K12581 K14821 KO01400 monothiol glutaredoxin; serine/threonine-protein phosphatase 4 catalytic subunit 1.1625701588 0.5 0.3463488 K07390 K15423 KO01406 nucleoporin SEH1; phosphoglucomutase / phosphopentomutase 0.7771356368 0.5 0.3463488 K14299 K15779 KO01409 coatomer protein complex, subunit epsilon; exonuclease 1 1.24322843565 1 0.03665871 K10746 K17268 KO01440 DNA ligase 4; protein phosphatase 1 regulatory subunit 11 1.3147217111 1 0.03665871 K10777 K17553 KO01454 nucleolar GTP-binding protein; ribosomal RNA-processing protein 8 1.61625999335 1 0.03665871 K06943 K14850 KO01475 ESCRT-I complex subunit TSG101; Ras-related C3 botulinum toxin substrate 1 1.34526826995 0.5 0.3463488 K04392 K12183 KO01484 GTP-binding protein SAR1; oligosaccharide translocation protein RFT1 1.14815440165 0.5 0.3463488 K06316 K07953 KO01531 OTU domain-containing protein 6; phosphoacetylglucosamine mutase 1.4984356986 1 0.03665871 K01836 K18342 KO01548 DNA repair protein RAD51; thymidine kinase 1.19644833585 0.5 0.3463488 K00857 K04482 KO01557 phosphatidylinositol glycan, class K; small subunit ribosomal protein S5e 1.8247041932 1 0.03665871 K02989 K05290 KO01559 phosphatidylinositol glycan, class Q; solute carrier family 25 (mitochondrial phosphate transporter), member 3 1.55717164635 0.5 0.3463488 K03860 K15102 KO01566 cation-transporting ATPase 13A1; putative transcription factor 1.6799076283 1 0.03665871 K03627 K14950 KO01568 DNA polymerase delta subunit 2; protein transport protein SEC24 1.49501457465 1 0.03665871 K02328 K14007 KO01625 V-type H+-transporting ATPase 16kDa proteolipid subunit; subunit C 1.82863213835 1 0.03665871 K02148 K02155 map04966: Collecting duct acid secretion; map04721: Synaptic vesicle cycle; map05110: Vibrio cholerae infection; map05323: Rheumatoid arthritis; map05120: Epithelial cell signaling in Helicobacter pylori infection; map04145: Phagosome; map00190: Oxidative phosphorylation KO01676 2-acylglycerol O-acyltransferase 2; microsomal epoxide hydrolase 1.736651464 1 0.03665871 K01253 K14457 KO01716 20S proteasome subunit alpha 2; suppressor of G2 allele of SKP1 1.45152302565 0.5 0.3463488 K02726 K12795 KO01719 ESCRT-II complex subunit VPS36; chromosome transmission fidelity protein 4; phosphatidylinositol glycan, class T 1.04973105223333 0.666666666666667 0.09594705 K05292 K11274 K12190 KO01743 SEL1 protein; small subunit ribosomal protein S5 0.6361423234 0.5 0.3463488 K02988 K14026 KO01761 protein farnesyltransferase subunit beta; ribosome biogenesis protein MAK21 1.2531036218 1 0.03665871 K05954 K14832 KO01763 rRNA 2'-O-methyltransferase fibrillarin; small subunit ribosomal protein S16e 1.82210315165 1 0.03665871 K02960 K14563 KO01773 microtubule-associated protein, RP/EB family; pre-mRNA-processing factor 6 1.41086881765 1 0.03665871 K10436 K12855 KO01789 glutaminyl-peptide cyclotransferase; mitochondrial import inner membrane translocase subunit TIM50 0.8747852308 0.5 0.3463488 K00683 K17496 KO03185 N-acetylmannosamine-6-phosphate epimerase and sialic acid lyase -2.717079878 1 0.03665871 K01639 K01788 map00520: Amino sugar and nucleotide sugar metabolism KO03222 Cu(I)/Ag(I) efflux system periplasmic protein CusF; membrane fusion protein, Cu(I)/Ag(I) efflux system; outer membrane protein, Cu(I)/Ag(I) efflux system -1.92690186743333 0.666666666666667 0.09594705 K07796 K07798 K07810 map02020: Two-component system KO03233 6-phospho-beta-glucosidase; AraC family transcriptional regulator, cel operon repressor; PTS system, cellobiose-specific IIA component; IIB component; IIC component -1.94366646168 0.6 0.05155955 K01222 K02759 K02760 K02761 K03490 KO03234 2-dehydro-3-deoxyglucarate aldolase; 2-hydroxy-3-oxopropionate reductase; MFS transporter, ACS family, probable galactarate transporter; glycerate kinase -1.53112922835 0.5 0.1678609 K00042 K00865 K01630 K12299 KO03280 glutathione-regulated potassium-efflux system ancillary protein KefC; KefF -3.64307456965 1 0.03665871 K11745 K11746 KO03381 cytosine deaminase; permease -1.00067264115 0.5 0.3463488 K01485 K10974 KO03445 putative ABC transport system ATP-binding protein; permease protein -1.814428386 1 0.03665871 K02068 K02069 KO03478 Cu(I)/Ag(I) efflux system membrane protein CusA/SilA; periplasmic protein CusF; membrane fusion protein, Cu(I)/Ag(I) efflux system -2.50698656736667 0.666666666666667 0.09594705 K07787 K07798 K07810 map02020: Two-component system KO03489 two-component system, CitB family, cit operon sensor histidine kinase CitA; response regulator CitB -3.7899458117 1 0.03665871 K07700 K07702 map02020: Two-component system KO03573 anaerobic dimethyl sulfoxide reductase subunit A; B (DMSO reductase iron- sulfur subunit); C (DMSO reductase anchor subunit) -2.018342175 0.333333333333333 0.4715497 K07306 K07307 K07308 map00920: Sulfur metabolism KO03645 PTS system, glucose-specific IIB component; IIC component -1.94846619695 0.5 0.3463488 K02778 K02779 map02060: Phosphotransferase system (PTS); map00010: Glycolysis / Gluconeogenesis; map00520: Amino sugar and nucleotide sugar metabolism KO03739 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase; 3-hydroxybutyryl-CoA dehydrogenase; 3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase; acyl-CoA thioesterase; enoyl-CoA hydratase; phenylacetate-CoA ligase; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA; PaaB; PaaC; PaaD; PaaE -0.443060040754545 0.0909090909090909 0.9036371 K00074 K01692 K01912 K02609 K02610 K02611 K02612 K02613 K02614 K02615 K15866 map00360: Phenylalanine metabolism KO03782 AI-2 transport system ATP-binding protein; permease protein; substrate-binding protein -2.76806545485 0.75 0.02403318 K10555 K10556 K10557 K10558 map02010: ABC transporters KO03783 autoinducer 2-degrading protein; putative autoinducer-2 (AI-2) aldolase -3.42402087635 1 0.03665871 K08321 K11530 KO03822 two-component system, OmpR family, response regulator RstA; sensor histidine kinase RstB -1.0457791127 0.5 0.3463488 K07639 K07661 map02020: Two-component system KO03993 dihydropyrimidine dehydrogenase (NAD+) subunit PreA; PreT -2.54039196475 1 0.03665871 K17722 K17723 map00770: Pantothenate and CoA biosynthesis; map00410: beta-Alanine metabolism; map00240: Pyrimidine metabolism KO04159 formate hydrogenlyase transcriptional activator; hydrogenase expression/formation protein HypC; HypD; HypE; nickel incorporation protein HypA/HybF; HypB -3.0106832058 1 4.902298e-05 K04651 K04652 K04653 K04654 K04655 K15836 KO04160 formate hydrogenlyase transcriptional activator; hydrogenase expression/formation protein HypE -2.30193580935 1 0.03665871 K04655 K15836 KO04173 DeoR family transcriptional regulator, L-fucose operon activator; L-fucose mutarotase -3.5064782593 1 0.03665871 K02430 K02431 KO04228 2,5-diketo-D-gluconate reductase A; NADP-dependent alcohol dehydrogenase -2.1602519007 0.5 0.3463488 K06221 K08325 KO04253 evolved beta-galactosidase subunit alpha; beta -2.99659196245 1 0.03665871 K12111 K12112 map00511: Other glycan degradation; map00052: Galactose metabolism KO04255 putative isomerase; suppressor of ftsI -1.9979340146 0.5 0.3463488 K03931 K04753 KO04389 DNA-3-methyladenine glycosylase I; putative acetyltransferase -1.6058186297 0.5 0.3463488 K01246 K03826 KO04480 ATP-dependent DNA helicase RecQ; threonine efflux protein -1.2890374741 0.5 0.3463488 K03654 K05835 KO04525 PTS system, fructose-specific IIB-like component; IIC-like component; formate C-acetyltransferase; pyruvate formate lyase activating enzyme -2.1476123446 1 0.001341665 K00656 K04069 K11202 K11203 KO04556 maltoporin; maltose operon periplasmic protein; multiple sugar transport system ATP-binding protein -1.57605142063333 0.333333333333333 0.4715497 K02024 K05775 K10111 KO04607 3-dehydro-L-gulonate-6-phosphate decarboxylase; L-ribulose-5-phosphate 3-epimerase; 4-epimerase; PTS system, ascorbate-specific IIA component; IIB component; IIC component -1.2534593993 0.333333333333333 0.3237626 K02821 K02822 K03077 K03078 K03079 K03475 map00053: Ascorbate and aldarate metabolism KO04617 antitoxin ChpS; mRNA interferase ChpB 1.38457496285 1 0.03665871 K18841 K18842 KO04641 fimbrial chaperone protein; minor fimbrial subunit; outer membrane usher protein -1.14453854552 0.2 0.6546254 K07346 K07347 K07348 K07349 K07350 KO04642 minor fimbrial subunit; outer membrane usher protein -1.103727656175 0.25 0.5727793 K07347 K07348 K07349 K07350 KO04660 deoxyribose-phosphate aldolase; phosphopentomutase; purine-nucleoside phosphorylase; thymidine phosphorylase -0.9053612585 0.25 0.5727793 K00758 K01619 K01839 K03784 KO04661 phosphopentomutase; purine-nucleoside phosphorylase -1.55372818395 0.5 0.3463488 K01839 K03784 map00230: Purine metabolism KO04768 MFS transporter, OHS family, lactose permease; galactoside O-acetyltransferase -3.41546408425 1 0.03665871 K00633 K02532 KO04921 KO06986 formate C-acetyltransferase; pyruvate formate lyase activating enzyme -1.7113857661 1 0.03665871 K00656 K04069 KO04935 NADH oxidoreductase Hcr; hydroxylamine reductase -3.5431730575 1 0.03665871 K05601 K11933 KO04982 LuxR family transcriptional regulator, csgAB operon transcriptional regulatory protein; curli production assembly/transport component CsgE; CsgF; CsgG -1.424677389875 0.25 0.5727793 K04333 K04337 K04338 K06214 KO05026 Na+:H+ antiporter, NhaA family; NhaB family -1.91052884945 0.5 0.3463488 K03313 K03314 KO05042 two-component system, NarL family, nitrate/nitrite response regulator NarL; sensor histidine kinase NarX -2.5340306695 0.5 0.3463488 K07673 K07684 map02020: Two-component system KO05137 autoinducer 2 (AI-2) kinase; lsr operon transcriptional repressor -3.66247252705 1 0.03665871 K11216 K11531 KO05212 6-phospho-beta-glucosidase; AraC family transcriptional regulator, cel operon repressor; PTS system, cellobiose-specific IIA component; IIB component; IIC component; hypothetical protein -1.99813519021667 0.666666666666667 0.01445887 K01222 K02759 K02760 K02761 K03478 K03490 KO05367 AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase; alkylated DNA repair protein (DNA oxidative demethylase) -0.75682155725 0.5 0.3463488 K03919 K10778 KO05414 MFS transporter, DHA2 family, multidrug resistance protein; multidrug resistance protein K -1.47453069205 0.5 0.3463488 K07786 K07797 map02020: Two-component system KO05438 ethanolamine transporter; utilization protein EutA -1.3308859464 0.5 0.3463488 K04019 K04023 KO05530 formate hydrogenlyase maturation protein HycH; regulatory protein HycA; subunit 2; 3; 4; 5; 6; 7; hydrogenase 3 maturation protease -3.37070951721111 1 3.413483e-07 K08315 K15827 K15828 K15829 K15830 K15831 K15832 K15833 K15834 KO05538 adenylylsulfate kinase; sulfate adenylyltransferase subunit 1; 2 -1.02855158823333 0.333333333333333 0.4715497 K00860 K00956 K00957 map00920: Sulfur metabolism; map00230: Purine metabolism KO05554 L-fuculose-phosphate aldolase; lactaldehyde reductase -1.58279341 0.5 0.3463488 K00048 K01628 KO05637 HTH-type transcriptional regulator / antitoxin MqsA; motility quorum-sensing regulator / GCU-specific mRNA interferase toxin; peptide/nickel transport system substrate-binding protein -2.5473628034 0.666666666666667 0.09594705 K02035 K13651 K13655 KO05839 molecular chaperone IbpA; IbpB -1.97405057075 0.5 0.3463488 K04080 K04081 KO05877 molybdopterin-guanine dinucleotide biosynthesis protein A; B -1.4053881614 0.5 0.3463488 K03752 K03753 KO05885 4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase; sulfofructosephosphate aldolase; sulfoquinovose isomerase -2.3384363467 1 0.007014544 K01671 K08318 K18479 KO05926 maltose/maltodextrin transport system permease protein; substrate-binding protein -2.31795416743333 0.333333333333333 0.4715497 K10108 K10109 K10110 map02010: ABC transporters KO05941 D-allose transport system ATP-binding protein; permease protein; D-allulose-6-phosphate 3-epimerase; allose kinase -1.934777195 0.5 0.1678609 K00881 K10550 K10551 K17195 KO06009 Fe(3+) dicitrate transport protein; RNA polymerase sigma-70 factor, ECF subfamily; transmembrane sensor -1.00703425876667 0.666666666666667 0.09594705 K03088 K07165 K16091 KO06120 hydrogenase expression/formation protein HypC; HypD; HypE; nickel incorporation protein HypB -3.405520100625 1 0.001341665 K04652 K04653 K04654 K04655 KO06121 hydrogenase expression/formation protein HypC; HypD; HypE; nickel incorporation protein HypA/HybF; HypB -3.33992371376 1 0.0002565139 K04651 K04652 K04653 K04654 K04655 KO06130 AI-2 transport system ATP-binding protein; permease protein; substrate-binding protein; autoinducer 2-degrading protein; putative autoinducer-2 (AI-2) aldolase; trans-aconitate 2-methyltransferase -2.67942779445714 0.714285714285714 0.003811463 K00598 K08321 K10555 K10556 K10557 K10558 K11530 KO06137 Fe(3+) dicitrate transport protein; iron complex transport system ATP-binding protein; permease protein; substrate-binding protein -0.669413977775 0.25 0.5727793 K02013 K02015 K02016 K16091 KO06147 curli production protein; major curlin subunit; minor curlin subunit -2.7414576873 1 0.007014544 K04334 K04335 K04336 KO06148 Cu(I)/Ag(I) efflux system membrane protein CusA/SilA; periplasmic protein CusF; membrane fusion protein, Cu(I)/Ag(I) efflux system; outer membrane protein, Cu(I)/Ag(I) efflux system -1.947764829375 0.5 0.1678609 K07787 K07796 K07798 K07810 map02020: Two-component system KO06152 RNA polymerase sigma-70 factor, ECF subfamily; transmembrane sensor -0.9287101277 0.5 0.3463488 K03088 K07165 KO06155 formate C-acetyltransferase; transporter -1.6743510929 0.5 0.3463488 K00656 K06212 KO06159 electron transport protein HydN; hydrogenase maturation protein HypF -3.4395002413 1 0.03665871 K04656 K05796 KO06197 MFS transporter, DHA2 family, multidrug resistance protein; MarR family transcriptional regulator, negative regulator of the multidrug operon emrRAB; membrane fusion protein, multidrug efflux system -1.0239182713 0.333333333333333 0.4715497 K03446 K03543 K15974 KO06212 flagella biosynthesis -0.500745665466667 0.333333333333333 0.4715497 K02407 K02422 K06603 KO06230 agmatine deiminase; hydrogenase expression/formation protein HypE; maturation protein HypF -2.2902879808 0.666666666666667 0.09594705 K04655 K04656 K10536 KO06235 urease subunit alpha; gamma/beta 1.06963293635 0.5 0.3463488 K01428 K14048 map00791: Atrazine degradation; map05120: Epithelial cell signaling in Helicobacter pylori infection; map00330: Arginine and proline metabolism; map00230: Purine metabolism KO06484 Fe(3+) dicitrate transport protein; holo-[acyl-carrier protein] synthase -0.64434862175 0.5 0.3463488 K00997 K16091 KO06522 hydrogenase expression/formation protein HypC; HypD; nickel incorporation protein HypB -3.46089648326667 1 0.007014544 K04652 K04653 K04654 KO06758 zinc uptake -0.856576347366667 0.333333333333333 0.4715497 K02076 K09816 K09817 KO06763 diphosphomevalonate decarboxylase; mevalonate kinase; phosphomevalonate kinase -0.9289407205 0.333333333333333 0.4715497 K00869 K00938 K01597 map00900: Terpenoid backbone biosynthesis KO06767 agmatine deiminase; carbamate kinase -1.6609851127 0.5 0.3463488 K00926 K10536 map00330: Arginine and proline metabolism KO06817 KO07307 PTS system, fructose-specific IIA component; IIB component; IIC component -1.38030956063333 0.333333333333333 0.4715497 K02768 K02769 K02770 map02060: Phosphotransferase system (PTS); map00051: Fructose and mannose metabolism KO06822 PTS system, cellobiose-specific IIB component; IIC component; beta-glucosidase -1.49222897386667 0.666666666666667 0.09594705 K02760 K02761 K05350 KO06826 PTS system, fructose-specific IIA component; IIB component; IIC component; activator of the mannose operon, transcriptional antiterminator; mannosylglycerate hydrolase -1.88667412744 0.6 0.05155955 K02538 K02768 K02769 K02770 K15524 KO06891 hypothetical protein; putative membrane protein 1.6827829163 1 0.03665871 K08981 K09167 KO06896 6-phospho-beta-glucosidase; PTS system, cellobiose-specific IIA component; IIB component; IIC component; lichenan operon transcriptional antiterminator -1.47575593434 0.4 0.2453951 K01223 K02759 K02760 K02761 K03491 KO06925 cyclic pyranopterin phosphate synthase; molybdate transport system substrate-binding protein; molybdopterin molybdotransferase; synthase catalytic subunit; sulfur carrier subunit; molybdopterin-guanine dinucleotide biosynthesis protein B -0.540430091028571 0.142857142857143 0.7742973 K02020 K03635 K03636 K03637 K03639 K03750 K03753 KO06999 KO10060 KO10379 KO10700 KO11054 hypothetical protein; small subunit ribosomal protein S21 0.80626217965 0.5 0.3463488 K02970 K09117 KO07238 PTS system, cellobiose-specific IIA component; IIB component; IIC component -1.71858105183333 0.666666666666667 0.09594705 K02759 K02760 K02761 map02060: Phosphotransferase system (PTS) KO07259 6-phospho-beta-glucosidase; PTS system, cellobiose-specific IIA component; IIB component; IIC component; beta-glucoside kinase -1.77048165104 0.6 0.05155955 K01223 K02759 K02760 K02761 K18673 KO07642 arginine deiminase pathway -1.837324501775 0.5 0.1678609 K00611 K00926 K01478 K03758 KO07644 KO13881 two-component regulatory system 1.14414453885 1 0.03665871 K02667 K02668 map02020: Two-component system KO07648 biosynthesis of pyochelin -1.60904957115 0.25 0.5727793 K01851 K04782 K12238 K12242 KO07657 pyocheline sysnthesis -2.192733775 0.5 0.3463488 K12239 K12240 map01053: Biosynthesis of siderophore group nonribosomal peptides KO07803 signal recognition particle subunit SRP19; small subunit ribosomal protein S8e 1.319777703 0.5 0.3463488 K02995 K03105 KO07844 elongation factor 1-alpha; small subunit ribosomal protein S10 0.87548783985 0.5 0.3463488 K02946 K03231 KO07848 N utilization substance protein A; large subunit ribosomal protein L30e 0.78881939755 0.5 0.3463488 K02600 K02908 KO07852 large subunit ribosomal protein L24e; nucleoside-diphosphate kinase 1.109412711 0.5 0.3463488 K00940 K02896 KO07899 2-(3-amino-3-carboxypropyl)histidine synthase; large subunit ribosomal protein L10e 1.55778723615 1 0.03665871 K02866 K07561 KO07911 NADH-quinone oxidoreductase subunit A; C; D; H; I; J 0.494775396983333 0.333333333333333 0.3237626 K00330 K00332 K00333 K00337 K00338 K00339 map00190: Oxidative phosphorylation KO07922 large subunit ribosomal protein L31e; L39e; programmed cell death protein 5; small subunit ribosomal protein S19e 1.6681285073 0.75 0.02403318 K02910 K02924 K02966 K06875 KO07958 large subunit ribosomal protein L14e; tRNA pseudouridine55 synthase 0.7359941906 0.5 0.3463488 K02875 K03177 KO07980 N6-L-threonylcarbamoyladenine synthase; TP53 regulating kinase and related kinases; XTP/dITP diphosphohydrolase 0.500561186033333 0.333333333333333 0.4715497 K01409 K02428 K08851 KO08075 5'-phosphate synthase pdxT subunit; pyridoxal 5'-phosphate synthase pdxS subunit; small subunit ribosomal protein S26e 0.958179933533333 0.333333333333333 0.4715497 K02976 K06215 K08681 KO08104 nucleolar GTP-binding protein; tRNA-binding protein 1.1518850825 0.5 0.3463488 K06878 K06943 KO08139 large subunit ribosomal protein L14; L15; L18; L19e; L24; L30; L32e; L5; L6; small subunit ribosomal protein S14; S17; S4e; S5; S8 0.600994866157143 0.214285714285714 0.5196755 K02874 K02876 K02881 K02885 K02895 K02907 K02912 K02931 K02933 K02954 K02961 K02987 K02988 K02994 map03010: Ribosome KO08145 2-haloacid dehalogenase; elongation factor 2 1.0762544842 0.5 0.3463488 K01560 K03234 KO08148 U3 small nucleolar ribonucleoprotein protein IMP4; large subunit ribosomal protein L37Ae 1.51826135985 1 0.03665871 K02921 K14561 KO08149 exosome complex component RRP4; RRP41; RRP42; proteasome alpha subunit; ribosome maturation protein SDO1 1.07993136744 0.4 0.2453951 K03432 K03679 K11600 K12589 K14574 KO08153 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase; small subunit ribosomal protein S3Ae 0.94863034285 0.5 0.3463488 K02984 K04042 KO08334 molybdate/tungstate transport system permease protein; substrate-binding protein -1.2175498577 0.333333333333333 0.4715497 K07124 K15495 K15496 KO08346 large subunit ribosomal protein L44e; small subunit ribosomal protein S27e; translation initiation factor 2 subunit 1 1.83124484113333 0.666666666666667 0.09594705 K02929 K02978 K03237 KO09244 RIO kinase 1; ribosomal RNA assembly protein; translation initiation factor 1A 1.33034366196667 0.666666666666667 0.09594705 K03236 K06961 K07178 KO09285 RNA 3'-terminal phosphate cyclase (ATP); large subunit ribosomal protein L13e 1.05427803645 0.5 0.3463488 K01974 K02873 KO09862 photosystem I core complex 0.9727322229 0.5 0.3463488 K02689 K02690 map00195: Photosynthesis KO09884 KO09887 ABC transporter; pgm-independent transport system -3.608991682625 1 0.001341665 K11604 K11605 K11606 K11607 map02010: ABC transporters KO09917 KO10279 KO10940 cytochrome c-type protein NapB; ferredoxin-type protein NapF; periplasmic nitrate reductase NapA; NapD -0.926236895725 0.25 0.5727793 K02567 K02568 K02570 K02572 KO09946 KO10306 KO10621 KO10970 arginine deiminase; carbamate kinase; ornithine carbamoyltransferase -1.7873792788 0.333333333333333 0.4715497 K00611 K00926 K01478 map00330: Arginine and proline metabolism KO09984 KO10328 KO11002 UDP-glucuronate 4-epimerase; UDPglucose 6-dehydrogenase; UTP--glucose-1-phosphate uridylyltransferase 0.598729145166667 0.333333333333333 0.4715497 K00012 K00963 K08679 map00500: Starch and sucrose metabolism; map00520: Amino sugar and nucleotide sugar metabolism KO10028 MSHA biogenesis protein MshI; MshJ -1.50123625485 0.5 0.3463488 K12279 K12280 KO10069 KO10386 KO10710 KO11063 6-phospho-beta-glucosidase; hypothetical protein -1.65502166285 0.5 0.3463488 K01222 K03478 KO10084 KO10399 KO10726 KO11076 phosphopentomutase; thymidine phosphorylase -0.96464546625 0.5 0.3463488 K00758 K01839 KO10104 flagellar hook-associated protein 2; protein FlaG -0.70419322695 0.5 0.3463488 K02407 K06603 KO10628 cytochrome c-type protein NapB; periplasmic nitrate reductase NapA; NapD -1.06335901816667 0.333333333333333 0.4715497 K02567 K02568 K02570 KO10785 1-phosphofructokinase; PTS system, fructose-specific IIB component; IIC component -1.1097561744 0.333333333333333 0.4715497 K00882 K02769 K02770 map00051: Fructose and mannose metabolism KO11227 twitching motility protein PilT; PilU 1.05698457735 0.5 0.3463488 K02669 K02670 KO11297 KO11343 KO11381 KO11439 maltose/maltodextrin transport system permease protein -2.3711489013 0.5 0.3463488 K10109 K10110 map02010: ABC transporters KO12507 KO12636 arsenate-mycothiol transferase; arsenite transporter, ACR3 family 1.0972785452 0.5 0.3463488 K03325 K18701 KO12550 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase; mannose-1-phosphate guanylyltransferase 1.0533766749 0.5 0.3463488 K00966 K16870 KO12718 muconate cycloisomerase; muconolactone D-isomerase -1.5123665733 0.5 0.3463488 K01856 K03464 map00362: Benzoate degradation; map01220: Degradation of aromatic compounds KO12880 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; putative zinc metalloprotease 0.5117763143 0.333333333333333 0.4715497 K00099 K01417 K03526 KO12890 putative ABC transport system ATP-binding protein; permease protein; substrate-binding protein -1.24055931183333 0.333333333333333 0.4715497 K01989 K05832 K05833 KO13854 type IV pilus assembly protein PilP; PilQ 0.6898882136 0.5 0.3463488 K02665 K02666 KO13921 TatD DNase family protein; type IV pilus assembly protein PilZ 0.6263758543 0.5 0.3463488 K02676 K03424 KO13945 leader peptidase (prepilin peptidase) / N-methyltransferase; type IV pilus assembly protein PilB; PilC 0.682171392533333 0.333333333333333 0.4715497 K02652 K02653 K02654 KO14120 DNA primase; hypothetical protein; small subunit ribosomal protein S21 0.581483554233333 0.333333333333333 0.4715497 K02316 K02970 K09117 KO14162 hydrogenase maturation protein HypF; nickel incorporation protein HypA/HybF; HypB -3.24437008796667 1 0.007014544 K04651 K04652 K04656 KO14166 MtN3 and saliva related transmembrane protein; thiamine pyrophosphokinase -1.38983640065 0.5 0.3463488 K00949 K15383 KO14226 NADH-quinone oxidoreductase subunit A; B; C; D; E; F; G; H; I; J; K; L; M; N 0.324154614542857 0.142857142857143 0.7801147 K00330 K00331 K00332 K00333 K00334 K00335 K00336 K00337 K00338 K00339 K00340 K00341 K00342 K00343 map00190: Oxidative phosphorylation KO14271 acetylornithine aminotransferase; superoxide dismutase, Fe-Mn family 0.71856381395 0.5 0.3463488 K00818 K04564 KO14296 4'-phosphopantetheinyl transferase; tRNA (guanine9-N1)-methyltransferase 1.1550857663 0.5 0.3463488 K06133 K15445 KO14330 RNA exonuclease 4; beta-1,4-mannosyltransferase 1.3950408986 1 0.03665871 K03842 K18327 KO14359 propionyl-CoA carboxylase alpha chain; splicing factor, arginine/serine-rich 4/5/6 0.80531479895 0.5 0.3463488 K01965 K12893 KO14371 ATP synthase mitochondrial F1 complex assembly factor 2; U3 small nucleolar RNA-associated protein 13 0.99061574965 0.5 0.3463488 K07556 K14555 KO14378 large subunit ribosomal protein L27e; nuclear pore complex protein Nup53 1.17600314135 0.5 0.3463488 K02901 K14313 KO14379 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43; ubiquitin carboxyl-terminal hydrolase 36/42 0.87746851125 0.5 0.3463488 K11855 K12820 KO14381 cyclin-dependent kinase 7; mitochondrial fission 1 protein 1.67762481935 1 0.03665871 K02202 K17969 KO14429 dolichyl-phosphate beta-glucosyltransferase; syntaxin 5 1.223594229 0.5 0.3463488 K00729 K08490 KO14496 T-complex protein 1 subunit gamma; serine/threonine-protein phosphatase 4 catalytic subunit 1.9567080627 1 0.03665871 K09495 K15423 KO14507 polyribonucleotide 5'-hydroxyl-kinase; small nuclear ribonucleoprotein D2 1.4224186381 0.5 0.3463488 K11096 K14399 KO14518 DNA polymerase delta subunit 2; transcription initiation factor TFIID subunit 5 1.182563781 0.5 0.3463488 K02328 K03130 KO14540 RNA 3'-terminal phosphate cyclase-like protein 1.2500008481 0.5 0.3463488 K06883 K11108 KO14588 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.86048625065 0.5 0.3463488 K01139 K03965 KO14592 20S proteasome subunit alpha 4; mitochondrial inner membrane protein COX18 1.05508474435 0.5 0.3463488 K02731 K17797 KO14597 diphthine synthase; small subunit ribosomal protein S7 1.2571392752 0.5 0.3463488 K00586 K02992 KO14664 small subunit ribosomal protein S10; ubiquitin carboxyl-terminal hydrolase 5/13 0.7903538749 0.5 0.3463488 K02946 K11836 KO14677 DNA replication ATP-dependent helicase Dna2; U3 small nucleolar ribonucleoprotein protein LCP5 1.2463592623 1 0.03665871 K10742 K14765 KO14683 ADP-ribosylation factor related protein 1; protein phosphatase inhibitor 2 1.31842301245 0.5 0.3463488 K07952 K16833 KO14686 poly(ADP-ribose) glycohydrolase ARH3; transcription initiation factor TFIIH subunit 1 0.66498849645 0.5 0.3463488 K03141 K11687 KO14717 ATP-dependent RNA helicase DDX51/DBP6; vacuolar protein sorting-associated protein 35 1.54723570055 1 0.03665871 K14807 K18468 KO14736 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); cytochrome b pre-mRNA-processing protein 3 1.26953318465 0.5 0.3463488 K09699 K17662 KO14770 20S proteasome subunit beta 6; SEL1 protein 1.49690308625 1 0.03665871 K02732 K14026 KO14773 E3 ubiquitin-protein ligase HUWE1; RIO kinase 1 0.70574741735 0.5 0.3463488 K07178 K10592 KO14788 ATP-dependent RNA helicase DDX49/DBP8; WW domain-binding protein 11 0.9136878655 0.5 0.3463488 K12866 K14778 KO14792 E3 ubiquitin-protein ligase synoviolin; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) 1.230265676 0.5 0.3463488 K04649 K10601 map04120: Ubiquitin mediated proteolysis KO14807 DNA-directed RNA polymerase III subunit RPC6; LETM1 and EF-hand domain-containing protein 1, mitochondrial 1.04466665525 0.5 0.3463488 K03025 K17800 KO14817 elongator complex protein 3; splicing factor 3B subunit 2; tRNA(His) guanylyltransferase 1.67750669576667 1 0.007014544 K07739 K10761 K12829 KO14830 cysteine protease ATG4; glutathione gamma-glutamylcysteinyltransferase 0.85386773265 0.5 0.3463488 K05941 K08342 KO14838 coenzyme Q-binding protein COQ10; protein Mpv17 1.74595573515 1 0.03665871 K13348 K18588 KO14842 RNA-binding motif protein, X-linked 2; RalA-binding protein 1 1.0366396628 0.5 0.3463488 K08773 K13107 KO14849 elongator complex protein 1; protein KRI1 0.89315005165 0.5 0.3463488 K11373 K14786 KO14859 peroxin-13; vacuolar protein sorting-associated protein 45 1.397185665 1 0.03665871 K12479 K13344 KO14928 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; 20S proteasome subunit beta 3 2.1371167462 1 0.03665871 K02735 K06127 KO14935 DNA polymerase beta; serine/threonine-protein phosphatase PP1 catalytic subunit 0.95981647105 0.5 0.3463488 K02330 K06269 KO14941 V-type H+-transporting ATPase subunit D; bromodomain-containing protein 7/9; exosome complex component RRP42 0.9131409847 0.333333333333333 0.4715497 K02149 K11723 K12589 KO14958 alpha-glucosidase; translation initiation factor 3 subunit A 1.01589057925 0.5 0.3463488 K01187 K03254 KO14959 Derlin-2/3; solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 1.51738511885 1 0.03665871 K13989 K15278 KO14971 EKC/KEOPS complex subunit CGI121/TPRKB; condensin complex subunit 2 0.85266971645 0.5 0.3463488 K06676 K15901 KO15023 splicing factor U2AF 35 kDa subunit; tRNA (cytosine38-C5)-methyltransferase 1.04109369115 0.5 0.3463488 K12836 K15336 KO15024 GDP-L-fucose synthase; tRNA pseudouridine38/39 synthase 1.03577885425 0.5 0.3463488 K01855 K02377 KO15027 SAGA-associated factor 29; actin related protein 2/3 complex, subunit 5 0.89392382195 0.5 0.3463488 K05754 K11364 KO15032 UDP-glucuronate decarboxylase; prefoldin subunit 2 1.59078347035 0.5 0.3463488 K08678 K09549 KO15038 ADP-ribosylation factor-like protein 2; U3 small nucleolar RNA-associated protein 15; dynactin 1 1.31264904896667 0.333333333333333 0.4715497 K04648 K07943 K14549 KO15042 WD repeat-containing protein 48; protein N-terminal methyltransferase 1.06462534375 0.5 0.3463488 K15361 K16219 KO15077 chitinase domain-containing protein 1; proliferating cell nuclear antigen 0.9181259388 0.5 0.3463488 K04802 K17525 KO15119 tRNA-dihydrouridine synthase 1; tyrosyl-tRNA synthetase 0.8710959084 0.5 0.3463488 K01866 K05542 KO15161 cytoplasmic tRNA 2-thiolation protein 1; histidyl-tRNA synthetase 1.12110264085 0.5 0.3463488 K01892 K14168 KO15174 NADH dehydrogenase (ubiquinone) Fe-S protein 2; ribosomal biogenesis protein LAS1 1.394355464 0.5 0.3463488 K03935 K16912 KO15185 autophagy-related protein 5; pre-rRNA-processing protein TSR1 0.9385968159 0.5 0.3463488 K08339 K14799 KO15213 ubiquitin fusion degradation protein 1; unconventional SNARE in the endoplasmic reticulum protein 1 0.73638277205 0.5 0.3463488 K08507 K14016 KO15288 ubiquinone biosynthesis protein COQ9; ubiquitin-like-conjugating enzyme ATG10, animal type 1.0342983821 0.5 0.3463488 K17888 K18587 KO15346 GMP reductase; phytanoyl-CoA hydroxylase -1.66306704275 0.5 0.3463488 K00364 K00477 KO15390 translation initiation factor 3 subunit J; K 1.17126633925 0.5 0.3463488 K03245 K15028 KO15410 peptidylprolyl isomerase domain and WD repeat-containing protein 1; replication factor A3 0.88333250295 0.5 0.3463488 K10740 K12736 KO15446 peptide chain release factor 1; ribosomal RNA-processing protein 1 0.68503871415 0.5 0.3463488 K02835 K14849 KO15494 ATP-dependent RNA helicase DDX54/DBP10; exosome complex component RRP46 1.2271637936 1 0.03665871 K12590 K14808 KO15497 isocitrate dehydrogenase (NAD+); ubiquitin-conjugating enzyme E2 G2 2.3662064041 1 0.03665871 K00030 K04555 KO15503 seryl-tRNA synthetase; translation initiation factor 5B 0.8954342919 0.5 0.3463488 K01875 K03243 KO15518 dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4; myosin regulatory light chain 12 1.23551152235 0.5 0.3463488 K12757 K18669 KO15522 U4/U6.U5 tri-snRNP-associated protein 2; large subunit ribosomal protein L1 0.9476525871 0.5 0.3463488 K02863 K12847