ADDIS - Aggregate Data Drug Information System
ADDIS comes with two built-in examples:
An anti-depressants example modeled on the paper: Hansen et al., Annals of internal medicine, 143(6): 415-426, 2005. All data was extracted by us from the original papers.
A hypertension example based on the EMA EPAR evaluating Edarbi. The data were imported from ClinicalTrials.gov, with manual corrections where needed.
ADDIS is made in Java, and requires Java 6 (JRE 1.6) or newer. Most modern operating systems ship with a suitable JRE.
1.16.4: JSON export of benefit-risk models; bugfixes.
1.16.3: Bugfix release.
1.16.2: Bugfix release.
1.16.1: Updated to GeMTC 0.14.1 for bugfixes and minor improvements.
1.16: Drug treatments can now be stratified by dose and dosing type with the new 'treatment' functionality. Dose stratifications can be used in network meta-analyses and pairwise meta-analyses. Added hypertension example data set. Allow importing of results from clinicaltrials.gov (experimental). Fixed bugs which could lead to data loss.
1.14.1: Bugfix release.
1.14: Network meta-analysis results can now be saved in the ADDIS data file. In addition, the computations can be reset and there is a new visual progress indicator.
1.12.5: Bugfix release.
1.12.4: The network meta-analysis simulation can be continued if it has not converged yet, and there is a new GUI for checking convergence. The benefit-risk analysis now uses the full covariance information from network meta-analysis. Reduced download from 30MB to 15MB. Bugfixes.
1.12.3: Bugfix release.
1.12.2: Bugfix release.
1.12.1: Input name of analyses in the first step of the wizard, not in a pop-up dialog at the very end.
1.12: Add BRAT table and its value tree to benefit-risk view, allow selection of baseline in benefit-risk analysis, enable BRAT description of benefit-risk analysis, improve performance of network meta-analysis wizard, clarify error dialog with bug reporting instructions, fix many bugs.
1.10.1: Bugfix release
1.10: Enable combination treatment. Add "free text" ('Other') activity. Allow multiple moments of measurement for each outcome. Add installer and double-click loading of .addis data files on Windows.
1.8: Input study design (time structure), allow missing measurements, generate summary of efficacy table according to EMA D80 template, support of primary/secondary endpoints.
1.6.2: Bugfix release
1.6.1: Performance improvements for network meta-analysis, rank probability table.
1.6: User interface improvements, risk-based sampling in MetaBR, new schema-based XML format, added note taking in study wizard.
1.4: Lynd & O'Brien benefit-risk analysis, corrected meta-analysis, network meta-analysis enhancements (assessment of convergence, variance parameters, node-splitting analysis, R-dump of results, memory management), tabbed views.
1.2.1: Bugfix release
1.2: Benefit-risk models based on a single study.
1.0: Welcome screen, limited editing, links to various information systems (PubMed, medicines.org.uk, whocc.no) and many minor improvements.
0.10: Benefit-risk analysis, baseline effect (heuristic) estimation
0.8.1: Faster network meta-analysis (updated library), minor fixes
0.8: Network meta-analysis, XML import/export
0.6: Added add-study-wizard, import from ClinicalTrials.gov
0.4.1: Fixed example data (studies Org 022 and 023), changed domain to be version-specific.
0.4: Added meta-analysis, removed combined studies and MCDA-hookup. Lots of minor changes.
0.2: Initial release.
Building ADDIS from source
All releases as well as a nightly build (see the DrugIS website) are distributed in a compiled format. However, we also provide source for external development / verification. The sources can be checked out of the ADDIS Git repository.
In order to compile ADDIS, you need:
- Java >= 1.6
- Maven 2
- Other dependencies should be downloaded automatically by Maven2
Building is automatic with "mvn package".
Developing ADDIS using Eclipse
First, let Maven configure your workspace for use with Maven:
$ mvn eclipse:configure-workspace -Declipse.workspace=WORKSPACE_DIR
Use Maven to generate the eclipse project:
$ cd SOURCE_DIR $ mvn eclipse:eclipse
Then import the project into Eclipse (File -> Import -> Existing projects).
For contact information, see the ADDIS website.
ADDIS Development Team