system-pbpk_template.txt

# Author: name <email>
#
# System Units:
#                
#   mass          [=] ?
#   volume        [=] ml
#   concentration [=] ?
#   time          [=] hr 

# #-------------#
# | References  |
# #-------------#
#
#
# This system file contains the parameters from the following model:
#
#   Shah, D. K., & Betts, A. M. (2012). Towards a platform PBPK model to
#   characterize the plasma and tissue disposition of monoclonal antibodies in
#   preclinical species and human. Journal of pharmacokinetics and
#   biopharmaceutics, 39(1), 67-86. #
#
# This contains all of the species using the following nomenclature:
#
#  MO - mouse
#  RA - rat
#  RH - rhesus monkey
#  HU - human
#
# This is provided to demonstrate how parameter sets and mathematical sets can
# be used to switch between species easily. Slight modifications have been
# made. Namely the other ("OT") tissue compartment is calculated instead of
# being specified explicitly. The Total provided represent the values of all
# components provided in the original reference and the other is the total
# minus the sum of the components. This is done to prevent artifacts
# associated with rounding when the parameters were presented in the
# publication. 
#
#
# The following control parameters are used as internal switches:
#
#  EN_SP_XX where X is the species above.
#
# To switch between species simply set the human (default species) to zero and
# the species you want to 1. For example to specify rat as the species:
#
#  EN_SP_HU  = 0
#  EN_SP_RA  = 1
#
# This should be done using the PSET notation below or at the scripting level.
# Its not a good idea to change the defaults below.
#
#
# Common conversions
#
# Half-life to rate:
#
#        ln(2)
#  kel = -----
#        thalf
#
# Convert ng/ml to nM
#
#    ng   1000 ml        nmoles
#  X -- x ------- x --------------- = X/MW (KDA)
#    ml    1L       MW (KDA)*1000 ng
# 
# Convert from nM to ng/ml:
#
# X nM  ===> X*MW(KDA) 
# 
# Converting dose in mpk to nmoles
#
#   mg            1e6 ng    1 nmole
# X -- x BW(kg) x ------ x -----------------  =>  X*1e3*BW/MW
#   kg            1 mg      MW (KDA) * 1000
#
#
# Converting dose in mpk to nM    
#
#   mg            1e6 ng    1 nmole             1
# X -- x BW(kg) x ------ x ----------------- x ---  =>  X*1e3*BW/MW/Vp
#   kg            1 mg      MW (KDA) * 1000    V(L)
#

# Define Sets
#
# <SET:SETNAME>  E1; E2; E3

# #-------------#
# | Parameters  |
# #-------------#
#
# System parameters
#     name                   value               lower             upper    units   editable    grouping
#                                                bound             bound            
# Mathematical sets
# All tissues for normal organs defined in the system parameters
<SET:ATI> AD; BO; BR; HE; KI; LI; LU; LV; MU; PA; SI; SK; SP; TH; TOT
# All tissues for normal organs defined in the system parameters
# Except the TOT tissue. This is used to define the parameters
# for the other (OT) tissue
<SET:ATI_NO_TOT> AD; BO; BR; HE; KI; LI; LU; LV; MU; PA; SI; SK; SP; TH
# Normal organ tissues (same as ATI but with TOT removed and OT (other) added
<SET:TI> AD; BO; BR; HE; KI; LI; LU; LV; MU; PA; SI; SK; SP; TH; OT
# Species
<SET:SP> HU; MO; RA; RH
# All system parameter names for normal organs
<SET:APN> V_TOT; V_PL; V_BC; V_IN; V_EN; V_CL; Q_PL; Q_BC
#   Name            Value        Lower Bound  Upper Bound  Units        Editable     Grouping     
# Species control parameters
<P> EN_SP_HU        1.0000       0            1            ---          no           SP_Control   
<P> EN_SP_MO        0            0            1            ---          no           SP_Control   
<P> EN_SP_RA        0            0            1            ---          no           SP_Control   
<P> EN_SP_RH        0            0            1            ---          no           SP_Control   
# Mouse : General
<P> BW_MO           0.0280       eps          inf          kg           no           General      
<P> BW_R_MO         0.0280       eps          inf          kg           no           General      
<P> V_TOT_LN_MO     0.1130       eps          inf          ml           no           General      
<P> V_CL_LN_MO      0.1130       eps          inf          ml           no           General      
<P> Q_PL_LN_MO      1.6500       eps          inf          ml/hr        no           General      
<P> Q_BC_LN_MO      1.3500       eps          inf          ml/hr        no           General      
<P> V_TOT_BC_MO     0.7730       eps          inf          ml           no           General      
<P> Q_BC_MO         305.0000     eps          inf          ml/hr        no           General      
<P> V_TOT_PL_MO     0.9440       eps          inf          ml           no           General      
<P> Q_PL_MO         373.0000     eps          inf          ml/hr        no           General      
# Mouse : Adipose
<P> V_TOT_AD_MO     1.98         eps          inf          ml           no           Adipose      
<P> V_PL_AD_MO      0.0218       eps          inf          ml           no           Adipose      
<P> V_BC_AD_MO      0.298        eps          inf          ml           no           Adipose      
<P> V_IN_AD_MO      0.337        eps          inf          ml           no           Adipose      
<P> V_EN_AD_MO      0.00991      eps          inf          ml           no           Adipose      
<P> V_CL_AD_MO      1.6          eps          inf          ml           no           Adipose      
<P> Q_PL_AD_MO      13.4         eps          inf          ml/hr        no           Adipose      
<P> Q_BC_AD_MO      11           eps          inf          ml/hr        no           Adipose      
# Mouse : Bone
<P> V_TOT_BO_MO     2.82         eps          inf          ml           no           Bone         
<P> V_PL_BO_MO      0.0621       eps          inf          ml           no           Bone         
<P> V_BC_BO_MO      0.378        eps          inf          ml           no           Bone         
<P> V_IN_BO_MO      0.525        eps          inf          ml           no           Bone         
<P> V_EN_BO_MO      0.0141       eps          inf          ml           no           Bone         
<P> V_CL_BO_MO      2.17         eps          inf          ml           no           Bone         
<P> Q_PL_BO_MO      15.2         eps          inf          ml/hr        no           Bone         
<P> Q_BC_BO_MO      12.4         eps          inf          ml/hr        no           Bone         
# Mouse : Brain
<P> V_TOT_BR_MO     0.485        eps          inf          ml           no           Brain        
<P> V_PL_BR_MO      0.0107       eps          inf          ml           no           Brain        
<P> V_BC_BR_MO      0.041        eps          inf          ml           no           Brain        
<P> V_IN_BR_MO      0.0873       eps          inf          ml           no           Brain        
<P> V_EN_BR_MO      0.00243      eps          inf          ml           no           Brain        
<P> V_CL_BR_MO      0.376        eps          inf          ml           no           Brain        
<P> Q_PL_BR_MO      11.8         eps          inf          ml/hr        no           Brain        
<P> Q_BC_BR_MO      9.64         eps          inf          ml/hr        no           Brain        
# Mouse : Heart
<P> V_TOT_HE_MO     0.152        eps          inf          ml           no           Heart        
<P> V_PL_HE_MO      0.00585      eps          inf          ml           no           Heart        
<P> V_BC_HE_MO      0.0323       eps          inf          ml           no           Heart        
<P> V_IN_HE_MO      0.0217       eps          inf          ml           no           Heart        
<P> V_EN_HE_MO      0.00076      eps          inf          ml           no           Heart        
<P> V_CL_HE_MO      0.119        eps          inf          ml           no           Heart        
<P> Q_PL_HE_MO      36.5         eps          inf          ml/hr        no           Heart        
<P> Q_BC_HE_MO      29.9         eps          inf          ml/hr        no           Heart        
# Mouse : Kidney
<P> V_TOT_KI_MO     0.525        eps          inf          ml           no           Kidney       
<P> V_PL_KI_MO      0.0289       eps          inf          ml           no           Kidney       
<P> V_BC_KI_MO      0.108        eps          inf          ml           no           Kidney       
<P> V_IN_KI_MO      0.0788       eps          inf          ml           no           Kidney       
<P> V_EN_KI_MO      0.00263      eps          inf          ml           no           Kidney       
<P> V_CL_KI_MO      0.391        eps          inf          ml           no           Kidney       
<P> Q_PL_KI_MO      68.5         eps          inf          ml/hr        no           Kidney       
<P> Q_BC_KI_MO      56.1         eps          inf          ml/hr        no           Kidney       
# Mouse : Lg_INT
<P> V_TOT_LI_MO     0.314        eps          inf          ml           no           Lg_INT       
<P> V_PL_LI_MO      0.005        eps          inf          ml           no           Lg_INT       
<P> V_BC_LI_MO      0.0375       eps          inf          ml           no           Lg_INT       
<P> V_IN_LI_MO      0.0545       eps          inf          ml           no           Lg_INT       
<P> V_EN_LI_MO      0.00157      eps          inf          ml           no           Lg_INT       
<P> V_CL_LI_MO      0.248        eps          inf          ml           no           Lg_INT       
<P> Q_PL_LI_MO      17.3         eps          inf          ml/hr        no           Lg_INT       
<P> Q_BC_LI_MO      14.1         eps          inf          ml/hr        no           Lg_INT       
# Mouse : Lung
<P> V_TOT_LU_MO     0.204        eps          inf          ml           no           Lung         
<P> V_PL_LU_MO      0.0295       eps          inf          ml           no           Lung         
<P> V_BC_LU_MO      0.189        eps          inf          ml           no           Lung         
<P> V_IN_LU_MO      0.0384       eps          inf          ml           no           Lung         
<P> V_EN_LU_MO      0.00102      eps          inf          ml           no           Lung         
<P> V_CL_LU_MO      0.111        eps          inf          ml           no           Lung         
<P> Q_PL_LU_MO      373          eps          inf          ml/hr        no           Lung         
<P> Q_BC_LU_MO      305          eps          inf          ml/hr        no           Lung         
# Mouse : Liver
<P> V_TOT_LV_MO     1.93         eps          inf          ml           no           Liver        
<P> V_PL_LV_MO      0.164        eps          inf          ml           no           Liver        
<P> V_BC_LV_MO      1.1          eps          inf          ml           no           Liver        
<P> V_IN_LV_MO      0.385        eps          inf          ml           no           Liver        
<P> V_EN_LV_MO      0.00963      eps          inf          ml           no           Liver        
<P> V_CL_LV_MO      1.23         eps          inf          ml           no           Liver        
<P> Q_PL_LV_MO      10.3         eps          inf          ml/hr        no           Liver        
<P> Q_BC_LV_MO      8.4          eps          inf          ml/hr        no           Liver        
# Mouse : Muscle
<P> V_TOT_MU_MO     11.3         eps          inf          ml           no           Muscle       
<P> V_PL_MU_MO      0.249        eps          inf          ml           no           Muscle       
<P> V_BC_MU_MO      2.19         eps          inf          ml           no           Muscle       
<P> V_IN_MU_MO      1.47         eps          inf          ml           no           Muscle       
<P> V_EN_MU_MO      0.0566       eps          inf          ml           no           Muscle       
<P> V_CL_MU_MO      9.34         eps          inf          ml           no           Muscle       
<P> Q_PL_MU_MO      86.1         eps          inf          ml/hr        no           Muscle       
<P> Q_BC_MU_MO      70.5         eps          inf          ml/hr        no           Muscle       
# Mouse : Pancreas
<P> V_TOT_PA_MO     0.097        eps          inf          ml           no           Pancreas     
<P> V_PL_PA_MO      0.00534      eps          inf          ml           no           Pancreas     
<P> V_BC_PA_MO      0.0448       eps          inf          ml           no           Pancreas     
<P> V_IN_PA_MO      0.0169       eps          inf          ml           no           Pancreas     
<P> V_EN_PA_MO      0.000485     eps          inf          ml           no           Pancreas     
<P> V_CL_PA_MO      0.0699       eps          inf          ml           no           Pancreas     
<P> Q_PL_PA_MO      6.24         eps          inf          ml/hr        no           Pancreas     
<P> Q_BC_PA_MO      5.1          eps          inf          ml/hr        no           Pancreas     
# Mouse : Sm_Int
<P> V_TOT_SI_MO     0.728        eps          inf          ml           no           Sm_Int       
<P> V_PL_SI_MO      0.0116       eps          inf          ml           no           Sm_Int       
<P> V_BC_SI_MO      0.0651       eps          inf          ml           no           Sm_Int       
<P> V_IN_SI_MO      0.127        eps          inf          ml           no           Sm_Int       
<P> V_EN_SI_MO      0.00364      eps          inf          ml           no           Sm_Int       
<P> V_CL_SI_MO      0.577        eps          inf          ml           no           Sm_Int       
<P> Q_PL_SI_MO      58.1         eps          inf          ml/hr        no           Sm_Int       
<P> Q_BC_SI_MO      47.5         eps          inf          ml/hr        no           Sm_Int       
# Mouse : Skin
<P> V_TOT_SK_MO     5.02         eps          inf          ml           no           Skin         
<P> V_PL_SK_MO      0.188        eps          inf          ml           no           Skin         
<P> V_BC_SK_MO      1.53         eps          inf          ml           no           Skin         
<P> V_IN_SK_MO      1.66         eps          inf          ml           no           Skin         
<P> V_EN_SK_MO      0.0251       eps          inf          ml           no           Skin         
<P> V_CL_SK_MO      3            eps          inf          ml           no           Skin         
<P> Q_PL_SK_MO      27.8         eps          inf          ml/hr        no           Skin         
<P> Q_BC_SK_MO      22.8         eps          inf          ml/hr        no           Skin         
# Mouse : Spleen
<P> V_TOT_SP_MO     0.127        eps          inf          ml           no           Spleen       
<P> V_PL_SP_MO      0.0154       eps          inf          ml           no           Spleen       
<P> V_BC_SP_MO      0.274        eps          inf          ml           no           Spleen       
<P> V_IN_SP_MO      0.0254       eps          inf          ml           no           Spleen       
<P> V_EN_SP_MO      0.000635     eps          inf          ml           no           Spleen       
<P> V_CL_SP_MO      0.073        eps          inf          ml           no           Spleen       
<P> Q_PL_SP_MO      8.18         eps          inf          ml/hr        no           Spleen       
<P> Q_BC_SP_MO      6.7          eps          inf          ml/hr        no           Spleen       
# Mouse : Thymus
<P> V_TOT_TH_MO     0.009        eps          inf          ml           no           Thymus       
<P> V_PL_TH_MO      5e-04        eps          inf          ml           no           Thymus       
<P> V_BC_TH_MO      0.00432      eps          inf          ml           no           Thymus       
<P> V_IN_TH_MO      0.00153      eps          inf          ml           no           Thymus       
<P> V_EN_TH_MO      5e-05        eps          inf          ml           no           Thymus       
<P> V_CL_TH_MO      0.00653      eps          inf          ml           no           Thymus       
<P> Q_PL_TH_MO      1.19         eps          inf          ml/hr        no           Thymus       
<P> Q_BC_TH_MO      0.97         eps          inf          ml/hr        no           Thymus       
# Mouse : Total
<P> V_TOT_TOT_MO    26.156       eps          inf          ml           no           Total        
<P> V_PL_TOT_MO     0.81719      eps          inf          ml           no           Total        
<P> V_BC_TOT_MO     6.50102      eps          inf          ml           no           Total        
<P> V_IN_TOT_MO     4.90823      eps          inf          ml           no           Total        
<P> V_EN_TOT_MO     0.13089      eps          inf          ml           no           Total        
<P> V_CL_TOT_MO     19.6594      eps          inf          ml           no           Total        
<P> Q_PL_TOT_MO     744.51       eps          inf          ml/hr        no           Total        
<P> Q_BC_TOT_MO     609.02       eps          inf          ml/hr        no           Total        
# Rat : General
<P> BW_RA           0.2800       eps          inf          kg           no           General      
<P> BW_R_RA         0.2800       eps          inf          kg           no           General      
<P> V_TOT_LN_RA     1.1500       eps          inf          ml           no           General      
<P> V_CL_LN_RA      1.1500       eps          inf          ml           no           General      
<P> Q_PL_LN_RA      16.8000      eps          inf          ml/hr        no           General      
<P> Q_BC_LN_RA      13.8000      eps          inf          ml/hr        no           General      
<P> V_TOT_BC_RA     7.4100       eps          inf          ml           no           General      
<P> Q_BC_RA         2.409e+03    eps          inf          ml/hr        no           General      
<P> V_TOT_PL_RA     9.0600       eps          inf          ml           no           General      
<P> Q_PL_RA         2.945e+03    eps          inf          ml/hr        no           General      
# Rat : Adipose
<P> V_TOT_AD_RA     33.1         eps          inf          ml           no           Adipose      
<P> V_PL_AD_RA      0.364        eps          inf          ml           no           Adipose      
<P> V_BC_AD_RA      0.298        eps          inf          ml           no           Adipose      
<P> V_IN_AD_RA      5.63         eps          inf          ml           no           Adipose      
<P> V_EN_AD_RA      0.166        eps          inf          ml           no           Adipose      
<P> V_CL_AD_RA      26.7         eps          inf          ml           no           Adipose      
<P> Q_PL_AD_RA      224          eps          inf          ml/hr        no           Adipose      
<P> Q_BC_AD_RA      184          eps          inf          ml/hr        no           Adipose      
# Rat : Bone
<P> V_TOT_BO_RA     21           eps          inf          ml           no           Bone         
<P> V_PL_BO_RA      0.462        eps          inf          ml           no           Bone         
<P> V_BC_BO_RA      0.378        eps          inf          ml           no           Bone         
<P> V_IN_BO_RA      3.9          eps          inf          ml           no           Bone         
<P> V_EN_BO_RA      0.105        eps          inf          ml           no           Bone         
<P> V_CL_BO_RA      16.1         eps          inf          ml           no           Bone         
<P> Q_PL_BO_RA      61.4         eps          inf          ml/hr        no           Bone         
<P> Q_BC_BO_RA      50.2         eps          inf          ml/hr        no           Bone         
# Rat : Brain
<P> V_TOT_BR_RA     2.28         eps          inf          ml           no           Brain        
<P> V_PL_BR_RA      0.0502       eps          inf          ml           no           Brain        
<P> V_BC_BR_RA      0.041        eps          inf          ml           no           Brain        
<P> V_IN_BR_RA      0.41         eps          inf          ml           no           Brain        
<P> V_EN_BR_RA      0.0114       eps          inf          ml           no           Brain        
<P> V_CL_BR_RA      1.77         eps          inf          ml           no           Brain        
<P> Q_PL_BR_RA      65.3         eps          inf          ml/hr        no           Brain        
<P> Q_BC_BR_RA      53.5         eps          inf          ml/hr        no           Brain        
# Rat : Heart
<P> V_TOT_HE_RA     1.02         eps          inf          ml           no           Heart        
<P> V_PL_HE_RA      0.0394       eps          inf          ml           no           Heart        
<P> V_BC_HE_RA      0.0323       eps          inf          ml           no           Heart        
<P> V_IN_HE_RA      0.146        eps          inf          ml           no           Heart        
<P> V_EN_HE_RA      0.00512      eps          inf          ml           no           Heart        
<P> V_CL_HE_RA      0.801        eps          inf          ml           no           Heart        
<P> Q_PL_HE_RA      151          eps          inf          ml/hr        no           Heart        
<P> Q_BC_HE_RA      124          eps          inf          ml/hr        no           Heart        
# Rat : Kidney
<P> V_TOT_KI_RA     2.41         eps          inf          ml           no           Kidney       
<P> V_PL_KI_RA      0.132        eps          inf          ml           no           Kidney       
<P> V_BC_KI_RA      0.108        eps          inf          ml           no           Kidney       
<P> V_IN_KI_RA      0.361        eps          inf          ml           no           Kidney       
<P> V_EN_KI_RA      0.012        eps          inf          ml           no           Kidney       
<P> V_CL_KI_RA      1.79         eps          inf          ml           no           Kidney       
<P> Q_PL_KI_RA      365          eps          inf          ml/hr        no           Kidney       
<P> Q_BC_KI_RA      298          eps          inf          ml/hr        no           Kidney       
# Rat : Lg_INT
<P> V_TOT_LI_RA     2.87         eps          inf          ml           no           Lg_INT       
<P> V_PL_LI_RA      0.0458       eps          inf          ml           no           Lg_INT       
<P> V_BC_LI_RA      0.0375       eps          inf          ml           no           Lg_INT       
<P> V_IN_LI_RA      0.5          eps          inf          ml           no           Lg_INT       
<P> V_EN_LI_RA      0.0144       eps          inf          ml           no           Lg_INT       
<P> V_CL_LI_RA      2.28         eps          inf          ml           no           Lg_INT       
<P> Q_PL_LI_RA      158          eps          inf          ml/hr        no           Lg_INT       
<P> Q_BC_LI_RA      130          eps          inf          ml/hr        no           Lg_INT       
# Rat : Lung
<P> V_TOT_LU_RA     1.4          eps          inf          ml           no           Lung         
<P> V_PL_LU_RA      0.231        eps          inf          ml           no           Lung         
<P> V_BC_LU_RA      0.189        eps          inf          ml           no           Lung         
<P> V_IN_LU_RA      0.263        eps          inf          ml           no           Lung         
<P> V_EN_LU_RA      0.007        eps          inf          ml           no           Lung         
<P> V_CL_LU_RA      0.71         eps          inf          ml           no           Lung         
<P> Q_PL_LU_RA      2945         eps          inf          ml/hr        no           Lung         
<P> Q_BC_LU_RA      2409         eps          inf          ml/hr        no           Lung         
# Rat : Liver
<P> V_TOT_LV_RA     15.7         eps          inf          ml           no           Liver        
<P> V_PL_LV_RA      1.34         eps          inf          ml           no           Liver        
<P> V_BC_LV_RA      1.1          eps          inf          ml           no           Liver        
<P> V_IN_LV_RA      2.56         eps          inf          ml           no           Liver        
<P> V_EN_LV_RA      0.0787       eps          inf          ml           no           Liver        
<P> V_CL_LV_RA      10.7         eps          inf          ml           no           Liver        
<P> Q_PL_LV_RA      21.1         eps          inf          ml/hr        no           Liver        
<P> Q_BC_LV_RA      17.3         eps          inf          ml/hr        no           Liver        
# Rat : Muscle
<P> V_TOT_MU_RA     122          eps          inf          ml           no           Muscle       
<P> V_PL_MU_RA      2.68         eps          inf          ml           no           Muscle       
<P> V_BC_MU_RA      2.19         eps          inf          ml           no           Muscle       
<P> V_IN_MU_RA      15.8         eps          inf          ml           no           Muscle       
<P> V_EN_MU_RA      0.608        eps          inf          ml           no           Muscle       
<P> V_CL_MU_RA      100          eps          inf          ml           no           Muscle       
<P> Q_PL_MU_RA      925          eps          inf          ml/hr        no           Muscle       
<P> Q_BC_MU_RA      757          eps          inf          ml/hr        no           Muscle       
# Rat : Pancreas
<P> V_TOT_PA_RA     1            eps          inf          ml           no           Pancreas     
<P> V_PL_PA_RA      0.0547       eps          inf          ml           no           Pancreas     
<P> V_BC_PA_RA      0.0448       eps          inf          ml           no           Pancreas     
<P> V_IN_PA_RA      0.173        eps          inf          ml           no           Pancreas     
<P> V_EN_PA_RA      0.00498      eps          inf          ml           no           Pancreas     
<P> V_CL_PA_RA      0.717        eps          inf          ml           no           Pancreas     
<P> Q_PL_PA_RA      63.4         eps          inf          ml/hr        no           Pancreas     
<P> Q_BC_PA_RA      51.8         eps          inf          ml/hr        no           Pancreas     
# Rat : Sm_Int
<P> V_TOT_SI_RA     4.99         eps          inf          ml           no           Sm_Int       
<P> V_PL_SI_RA      0.0795       eps          inf          ml           no           Sm_Int       
<P> V_BC_SI_RA      0.0651       eps          inf          ml           no           Sm_Int       
<P> V_IN_SI_RA      0.867        eps          inf          ml           no           Sm_Int       
<P> V_EN_SI_RA      0.0249       eps          inf          ml           no           Sm_Int       
<P> V_CL_SI_RA      3.95         eps          inf          ml           no           Sm_Int       
<P> Q_PL_SI_RA      398          eps          inf          ml/hr        no           Sm_Int       
<P> Q_BC_SI_RA      325          eps          inf          ml/hr        no           Sm_Int       
# Rat : Skin
<P> V_TOT_SK_RA     49.9         eps          inf          ml           no           Skin         
<P> V_PL_SK_RA      1.87         eps          inf          ml           no           Skin         
<P> V_BC_SK_RA      1.53         eps          inf          ml           no           Skin         
<P> V_IN_SK_RA      16.5         eps          inf          ml           no           Skin         
<P> V_EN_SK_RA      0.249        eps          inf          ml           no           Skin         
<P> V_CL_SK_RA      29.8         eps          inf          ml           no           Skin         
<P> Q_PL_SK_RA      200          eps          inf          ml/hr        no           Skin         
<P> Q_BC_SK_RA      163          eps          inf          ml/hr        no           Skin         
# Rat : Spleen
<P> V_TOT_SP_RA     2.77         eps          inf          ml           no           Spleen       
<P> V_PL_SP_RA      0.335        eps          inf          ml           no           Spleen       
<P> V_BC_SP_RA      0.274        eps          inf          ml           no           Spleen       
<P> V_IN_SP_RA      0.554        eps          inf          ml           no           Spleen       
<P> V_EN_SP_RA      0.0138       eps          inf          ml           no           Spleen       
<P> V_CL_SP_RA      1.59         eps          inf          ml           no           Spleen       
<P> Q_PL_SP_RA      179          eps          inf          ml/hr        no           Spleen       
<P> Q_BC_SP_RA      146          eps          inf          ml/hr        no           Spleen       
# Rat : Thymus
<P> V_TOT_TH_RA     0.096        eps          inf          ml           no           Thymus       
<P> V_PL_TH_RA      0.00528      eps          inf          ml           no           Thymus       
<P> V_BC_TH_RA      0.00432      eps          inf          ml           no           Thymus       
<P> V_IN_TH_RA      0.0163       eps          inf          ml           no           Thymus       
<P> V_EN_TH_RA      0.00048      eps          inf          ml           no           Thymus       
<P> V_CL_TH_RA      0.0696       eps          inf          ml           no           Thymus       
<P> Q_PL_TH_RA      12.2         eps          inf          ml/hr        no           Thymus       
<P> Q_BC_TH_RA      10           eps          inf          ml/hr        no           Thymus       
# Rat : Total
<P> V_TOT_TOT_RA    266.626      eps          inf          ml           no           Total        
<P> V_PL_TOT_RA     7.94488      eps          inf          ml           no           Total        
<P> V_BC_TOT_RA     6.50102      eps          inf          ml           no           Total        
<P> V_IN_TOT_RA     48.7203      eps          inf          ml           no           Total        
<P> V_EN_TOT_RA     1.33128      eps          inf          ml           no           Total        
<P> V_CL_TOT_RA     201.528      eps          inf          ml           no           Total        
<P> Q_PL_TOT_RA     5873.4       eps          inf          ml/hr        no           Total        
<P> Q_BC_TOT_RA     4804.4       eps          inf          ml/hr        no           Total        
# Rhesus : General
<P> BW_RH           6.2000       eps          inf          kg           no           General      
<P> BW_R_RH         6.2000       eps          inf          kg           no           General      
<P> V_TOT_LN_RH     25.1000      eps          inf          ml           no           General      
<P> V_CL_LN_RH      25.1000      eps          inf          ml           no           General      
<P> Q_PL_LN_RH      363.0000     eps          inf          ml/hr        no           General      
<P> Q_BC_LN_RH      297.0000     eps          inf          ml/hr        no           General      
<P> V_TOT_BC_RH     153.0000     eps          inf          ml           no           General      
<P> Q_BC_RH         1.836e+04    eps          inf          ml/hr        no           General      
<P> V_TOT_PL_RH     187.0000     eps          inf          ml           no           General      
<P> Q_PL_RH         2.243e+04    eps          inf          ml/hr        no           General      
# Rhesus : Adipose
<P> V_TOT_AD_RH     154          eps          inf          ml           no           Adipose      
<P> V_PL_AD_RH      1.7          eps          inf          ml           no           Adipose      
<P> V_BC_AD_RH      1.39         eps          inf          ml           no           Adipose      
<P> V_IN_AD_RH      26.3         eps          inf          ml           no           Adipose      
<P> V_EN_AD_RH      0.772        eps          inf          ml           no           Adipose      
<P> V_CL_AD_RH      124          eps          inf          ml           no           Adipose      
<P> Q_PL_AD_RH      139          eps          inf          ml/hr        no           Adipose      
<P> Q_BC_AD_RH      113          eps          inf          ml/hr        no           Adipose      
# Rhesus : Bone
<P> V_TOT_BO_RH     952          eps          inf          ml           no           Bone         
<P> V_PL_BO_RH      20.9         eps          inf          ml           no           Bone         
<P> V_BC_BO_RH      17.1         eps          inf          ml           no           Bone         
<P> V_IN_BO_RH      177          eps          inf          ml           no           Bone         
<P> V_EN_BO_RH      4.76         eps          inf          ml           no           Bone         
<P> V_CL_BO_RH      732          eps          inf          ml           no           Bone         
<P> Q_PL_BO_RH      248          eps          inf          ml/hr        no           Bone         
<P> Q_BC_BO_RH      203          eps          inf          ml/hr        no           Bone         
# Rhesus : Brain
<P> V_TOT_BR_RH     94           eps          inf          ml           no           Brain        
<P> V_PL_BR_RH      2.07         eps          inf          ml           no           Brain        
<P> V_BC_BR_RH      1.69         eps          inf          ml           no           Brain        
<P> V_IN_BR_RH      16.9         eps          inf          ml           no           Brain        
<P> V_EN_BR_RH      0.47         eps          inf          ml           no           Brain        
<P> V_CL_BR_RH      72.9         eps          inf          ml           no           Brain        
<P> Q_PL_BR_RH      1508         eps          inf          ml/hr        no           Brain        
<P> Q_BC_BR_RH      1234         eps          inf          ml/hr        no           Brain        
# Rhesus : Heart
<P> V_TOT_HE_RH     28.3         eps          inf          ml           no           Heart        
<P> V_PL_HE_RH      1.09         eps          inf          ml           no           Heart        
<P> V_BC_HE_RH      0.892        eps          inf          ml           no           Heart        
<P> V_IN_HE_RH      4.05         eps          inf          ml           no           Heart        
<P> V_EN_HE_RH      0.142        eps          inf          ml           no           Heart        
<P> V_CL_HE_RH      22.2         eps          inf          ml           no           Heart        
<P> Q_PL_HE_RH      696          eps          inf          ml/hr        no           Heart        
<P> Q_BC_HE_RH      570          eps          inf          ml/hr        no           Heart        
# Rhesus : Kidney
<P> V_TOT_KI_RH     27.3         eps          inf          ml           no           Kidney       
<P> V_PL_KI_RH      1.5          eps          inf          ml           no           Kidney       
<P> V_BC_KI_RH      1.23         eps          inf          ml           no           Kidney       
<P> V_IN_KI_RH      4.09         eps          inf          ml           no           Kidney       
<P> V_EN_KI_RH      0.136        eps          inf          ml           no           Kidney       
<P> V_CL_KI_RH      20.3         eps          inf          ml           no           Kidney       
<P> Q_PL_KI_RH      3237         eps          inf          ml/hr        no           Kidney       
<P> Q_BC_KI_RH      2649         eps          inf          ml/hr        no           Kidney       
# Rhesus : Lg_INT
<P> V_TOT_LI_RH     140          eps          inf          ml           no           Lg_INT       
<P> V_PL_LI_RH      2.24         eps          inf          ml           no           Lg_INT       
<P> V_BC_LI_RH      1.83         eps          inf          ml           no           Lg_INT       
<P> V_IN_LI_RH      24.4         eps          inf          ml           no           Lg_INT       
<P> V_EN_LI_RH      0.702        eps          inf          ml           no           Lg_INT       
<P> V_CL_LI_RH      111          eps          inf          ml           no           Lg_INT       
<P> Q_PL_LI_RH      3571         eps          inf          ml/hr        no           Lg_INT       
<P> Q_BC_LI_RH      2921         eps          inf          ml/hr        no           Lg_INT       
# Rhesus : Lung
<P> V_TOT_LU_RH     35.7         eps          inf          ml           no           Lung         
<P> V_PL_LU_RH      1.96         eps          inf          ml           no           Lung         
<P> V_BC_LU_RH      1.61         eps          inf          ml           no           Lung         
<P> V_IN_LU_RH      10.7         eps          inf          ml           no           Lung         
<P> V_EN_LU_RH      0.179        eps          inf          ml           no           Lung         
<P> V_CL_LU_RH      21.2         eps          inf          ml           no           Lung         
<P> Q_PL_LU_RH      22433        eps          inf          ml/hr        no           Lung         
<P> Q_BC_LU_RH      18355        eps          inf          ml/hr        no           Lung         
# Rhesus : Liver
<P> V_TOT_LV_RH     187          eps          inf          ml           no           Liver        
<P> V_PL_LV_RH      15.9         eps          inf          ml           no           Liver        
<P> V_BC_LV_RH      13           eps          inf          ml           no           Liver        
<P> V_IN_LV_RH      37.4         eps          inf          ml           no           Liver        
<P> V_EN_LV_RH      0.934        eps          inf          ml           no           Liver        
<P> V_CL_LV_RH      120          eps          inf          ml           no           Liver        
<P> Q_PL_LV_RH      1251         eps          inf          ml/hr        no           Liver        
<P> Q_BC_LV_RH      1023         eps          inf          ml/hr        no           Liver        
# Rhesus : Muscle
<P> V_TOT_MU_RH     3273         eps          inf          ml           no           Muscle       
<P> V_PL_MU_RH      72           eps          inf          ml           no           Muscle       
<P> V_BC_MU_RH      58.9         eps          inf          ml           no           Muscle       
<P> V_IN_MU_RH      426          eps          inf          ml           no           Muscle       
<P> V_EN_MU_RH      16.4         eps          inf          ml           no           Muscle       
<P> V_CL_MU_RH      2701         eps          inf          ml           no           Muscle       
<P> Q_PL_MU_RH      3944         eps          inf          ml/hr        no           Muscle       
<P> Q_BC_MU_RH      3227         eps          inf          ml/hr        no           Muscle       
# Rhesus : Pancreas
<P> V_TOT_PA_RH     12.5         eps          inf          ml           no           Pancreas     
<P> V_PL_PA_RH      0.685        eps          inf          ml           no           Pancreas     
<P> V_BC_PA_RH      0.56         eps          inf          ml           no           Pancreas     
<P> V_IN_PA_RH      2.17         eps          inf          ml           no           Pancreas     
<P> V_EN_PA_RH      0.0623       eps          inf          ml           no           Pancreas     
<P> V_CL_PA_RH      8.98         eps          inf          ml           no           Pancreas     
<P> Q_PL_PA_RH      399          eps          inf          ml/hr        no           Pancreas     
<P> Q_BC_PA_RH      327          eps          inf          ml/hr        no           Pancreas     
# Rhesus : Sm_Int
<P> V_TOT_SI_RH     98.7         eps          inf          ml           no           Sm_Int       
<P> V_PL_SI_RH      1.57         eps          inf          ml           no           Sm_Int       
<P> V_BC_SI_RH      1.29         eps          inf          ml           no           Sm_Int       
<P> V_IN_SI_RH      17.2         eps          inf          ml           no           Sm_Int       
<P> V_EN_SI_RH      0.494        eps          inf          ml           no           Sm_Int       
<P> V_CL_SI_RH      78.2         eps          inf          ml           no           Sm_Int       
<P> Q_PL_SI_RH      3432         eps          inf          ml/hr        no           Sm_Int       
<P> Q_BC_SI_RH      2808         eps          inf          ml/hr        no           Sm_Int       
# Rhesus : Skin
<P> V_TOT_SK_RH     674          eps          inf          ml           no           Skin         
<P> V_PL_SK_RH      25.2         eps          inf          ml           no           Skin         
<P> V_BC_SK_RH      20.6         eps          inf          ml           no           Skin         
<P> V_IN_SK_RH      223          eps          inf          ml           no           Skin         
<P> V_EN_SK_RH      3.37         eps          inf          ml           no           Skin         
<P> V_CL_SK_RH      403          eps          inf          ml           no           Skin         
<P> Q_PL_SK_RH      2492         eps          inf          ml/hr        no           Skin         
<P> Q_BC_SK_RH      2039         eps          inf          ml/hr        no           Skin         
# Rhesus : Spleen
<P> V_TOT_SP_RH     5.95         eps          inf          ml           no           Spleen       
<P> V_PL_SP_RH      0.72         eps          inf          ml           no           Spleen       
<P> V_BC_SP_RH      0.589        eps          inf          ml           no           Spleen       
<P> V_IN_SP_RH      1.19         eps          inf          ml           no           Spleen       
<P> V_EN_SP_RH      0.0298       eps          inf          ml           no           Spleen       
<P> V_CL_SP_RH      3.42         eps          inf          ml           no           Spleen       
<P> Q_PL_SP_RH      185          eps          inf          ml/hr        no           Spleen       
<P> Q_BC_SP_RH      151          eps          inf          ml/hr        no           Spleen       
# Rhesus : Thymus
<P> V_TOT_TH_RH     2.09         eps          inf          ml           no           Thymus       
<P> V_PL_TH_RH      0.115        eps          inf          ml           no           Thymus       
<P> V_BC_TH_RH      0.0941       eps          inf          ml           no           Thymus       
<P> V_IN_TH_RH      0.355        eps          inf          ml           no           Thymus       
<P> V_EN_TH_RH      0.0105       eps          inf          ml           no           Thymus       
<P> V_CL_TH_RH      1.52         eps          inf          ml           no           Thymus       
<P> Q_PL_TH_RH      125          eps          inf          ml/hr        no           Thymus       
<P> Q_BC_TH_RH      103          eps          inf          ml/hr        no           Thymus       
# Rhesus : Total
<P> V_TOT_TOT_RH    5816.54      eps          inf          ml           no           Total        
<P> V_PL_TOT_RH     153.21       eps          inf          ml           no           Total        
<P> V_BC_TOT_RH     125.325      eps          inf          ml           no           Total        
<P> V_IN_TOT_RH     993.455      eps          inf          ml           no           Total        
<P> V_EN_TOT_RH     29.1236      eps          inf          ml           no           Total        
<P> V_CL_TOT_RH     4518.62      eps          inf          ml           no           Total        
<P> Q_PL_TOT_RH     44505        eps          inf          ml/hr        no           Total        
<P> Q_BC_TOT_RH     36414        eps          inf          ml/hr        no           Total        
# Human : General
<P> BW_HU           71.0000      eps          inf          kg           no           General      
<P> BW_R_HU         71.0000      eps          inf          kg           no           General      
<P> V_TOT_LN_HU     274.0000     eps          inf          ml           no           General      
<P> V_CL_LN_HU      274.0000     eps          inf          ml           no           General      
<P> Q_PL_LN_HU      3.670e+03    eps          inf          ml/hr        no           General      
<P> Q_BC_LN_HU      3.002e+03    eps          inf          ml/hr        no           General      
<P> V_TOT_BC_HU     2.558e+03    eps          inf          ml           no           General      
<P> Q_BC_HU         1.488e+05    eps          inf          ml/hr        no           General      
<P> V_TOT_PL_HU     3.126e+03    eps          inf          ml           no           General      
<P> Q_PL_HU         1.819e+05    eps          inf          ml/hr        no           General      
# Human : Adipose
<P> V_TOT_AD_HU     13465        eps          inf          ml           no           Adipose      
<P> V_PL_AD_HU      148          eps          inf          ml           no           Adipose      
<P> V_BC_AD_HU      121          eps          inf          ml           no           Adipose      
<P> V_IN_AD_HU      2289         eps          inf          ml           no           Adipose      
<P> V_EN_AD_HU      67.3         eps          inf          ml           no           Adipose      
<P> V_CL_AD_HU      10840        eps          inf          ml           no           Adipose      
<P> Q_PL_AD_HU      11233        eps          inf          ml/hr        no           Adipose      
<P> Q_BC_AD_HU      9191         eps          inf          ml/hr        no           Adipose      
# Human : Bone
<P> V_TOT_BO_HU     10165        eps          inf          ml           no           Bone         
<P> V_PL_BO_HU      224          eps          inf          ml           no           Bone         
<P> V_BC_BO_HU      183          eps          inf          ml           no           Bone         
<P> V_IN_BO_HU      1891         eps          inf          ml           no           Bone         
<P> V_EN_BO_HU      50.8         eps          inf          ml           no           Bone         
<P> V_CL_BO_HU      7817         eps          inf          ml           no           Bone         
<P> Q_PL_BO_HU      2591         eps          inf          ml/hr        no           Bone         
<P> Q_BC_BO_HU      2120         eps          inf          ml/hr        no           Bone         
# Human : Brain
<P> V_TOT_BR_HU     1450         eps          inf          ml           no           Brain        
<P> V_PL_BR_HU      31.9         eps          inf          ml           no           Brain        
<P> V_BC_BR_HU      26.1         eps          inf          ml           no           Brain        
<P> V_IN_BR_HU      261          eps          inf          ml           no           Brain        
<P> V_EN_BR_HU      7.25         eps          inf          ml           no           Brain        
<P> V_CL_BR_HU      1124         eps          inf          ml           no           Brain        
<P> Q_PL_BR_HU      21453        eps          inf          ml/hr        no           Brain        
<P> Q_BC_BR_HU      17553        eps          inf          ml/hr        no           Brain        
# Human : Heart
<P> V_TOT_HE_HU     341          eps          inf          ml           no           Heart        
<P> V_PL_HE_HU      13.1         eps          inf          ml           no           Heart        
<P> V_BC_HE_HU      10.8         eps          inf          ml           no           Heart        
<P> V_IN_HE_HU      48.8         eps          inf          ml           no           Heart        
<P> V_EN_HE_HU      1.71         eps          inf          ml           no           Heart        
<P> V_CL_HE_HU      267          eps          inf          ml           no           Heart        
<P> Q_PL_HE_HU      7752         eps          inf          ml/hr        no           Heart        
<P> Q_BC_HE_HU      6342         eps          inf          ml/hr        no           Heart        
# Human : Kidney
<P> V_TOT_KI_HU     332          eps          inf          ml           no           Kidney       
<P> V_PL_KI_HU      18.2         eps          inf          ml           no           Kidney       
<P> V_BC_KI_HU      14.9         eps          inf          ml           no           Kidney       
<P> V_IN_KI_HU      49.8         eps          inf          ml           no           Kidney       
<P> V_EN_KI_HU      1.66         eps          inf          ml           no           Kidney       
<P> V_CL_KI_HU      247          eps          inf          ml           no           Kidney       
<P> Q_PL_KI_HU      36402        eps          inf          ml/hr        no           Kidney       
<P> Q_BC_KI_HU      29784        eps          inf          ml/hr        no           Kidney       
# Human : Lg_INT
<P> V_TOT_LI_HU     548          eps          inf          ml           no           Lg_INT       
<P> V_PL_LI_HU      8.74         eps          inf          ml           no           Lg_INT       
<P> V_BC_LI_HU      7.15         eps          inf          ml           no           Lg_INT       
<P> V_IN_LI_HU      95.3         eps          inf          ml           no           Lg_INT       
<P> V_EN_LI_HU      2.74         eps          inf          ml           no           Lg_INT       
<P> V_CL_LI_HU      434          eps          inf          ml           no           Lg_INT       
<P> Q_PL_LI_HU      12867        eps          inf          ml/hr        no           Lg_INT       
<P> Q_BC_LI_HU      10527        eps          inf          ml/hr        no           Lg_INT       
# Human : Lung
<P> V_TOT_LU_HU     1000         eps          inf          ml           no           Lung         
<P> V_PL_LU_HU      55           eps          inf          ml           no           Lung         
<P> V_BC_LU_HU      45           eps          inf          ml           no           Lung         
<P> V_IN_LU_HU      300          eps          inf          ml           no           Lung         
<P> V_EN_LU_HU      5            eps          inf          ml           no           Lung         
<P> V_CL_LU_HU      595          eps          inf          ml           no           Lung         
<P> Q_PL_LU_HU      181913       eps          inf          ml/hr        no           Lung         
<P> Q_BC_LU_HU      148838       eps          inf          ml/hr        no           Lung         
# Human : Liver
<P> V_TOT_LV_HU     2143         eps          inf          ml           no           Liver        
<P> V_PL_LV_HU      183          eps          inf          ml           no           Liver        
<P> V_BC_LV_HU      149          eps          inf          ml           no           Liver        
<P> V_IN_LV_HU      429          eps          inf          ml           no           Liver        
<P> V_EN_LV_HU      10.7         eps          inf          ml           no           Liver        
<P> V_CL_LV_HU      1371         eps          inf          ml           no           Liver        
<P> Q_PL_LV_HU      13210        eps          inf          ml/hr        no           Liver        
<P> Q_BC_LV_HU      10808        eps          inf          ml/hr        no           Liver        
# Human : Muscle
<P> V_TOT_MU_HU     30078        eps          inf          ml           no           Muscle       
<P> V_PL_MU_HU      662          eps          inf          ml           no           Muscle       
<P> V_BC_MU_HU      541          eps          inf          ml           no           Muscle       
<P> V_IN_MU_HU      3910         eps          inf          ml           no           Muscle       
<P> V_EN_MU_HU      150          eps          inf          ml           no           Muscle       
<P> V_CL_MU_HU      24815        eps          inf          ml           no           Muscle       
<P> Q_PL_MU_HU      33469        eps          inf          ml/hr        no           Muscle       
<P> Q_BC_MU_HU      27383        eps          inf          ml/hr        no           Muscle       
# Human : Pancreas
<P> V_TOT_PA_HU     104          eps          inf          ml           no           Pancreas     
<P> V_PL_PA_HU      5.7          eps          inf          ml           no           Pancreas     
<P> V_BC_PA_HU      4.66         eps          inf          ml           no           Pancreas     
<P> V_IN_PA_HU      18           eps          inf          ml           no           Pancreas     
<P> V_EN_PA_HU      0.518        eps          inf          ml           no           Pancreas     
<P> V_CL_PA_HU      74.7         eps          inf          ml           no           Pancreas     
<P> Q_PL_PA_HU      3056         eps          inf          ml/hr        no           Pancreas     
<P> Q_BC_PA_HU      2500         eps          inf          ml/hr        no           Pancreas     
# Human : Sm_Int
<P> V_TOT_SI_HU     385          eps          inf          ml           no           Sm_Int       
<P> V_PL_SI_HU      6.15         eps          inf          ml           no           Sm_Int       
<P> V_BC_SI_HU      5.03         eps          inf          ml           no           Sm_Int       
<P> V_IN_SI_HU      67.1         eps          inf          ml           no           Sm_Int       
<P> V_EN_SI_HU      1.93         eps          inf          ml           no           Sm_Int       
<P> V_CL_SI_HU      305          eps          inf          ml           no           Sm_Int       
<P> Q_PL_SI_HU      12368        eps          inf          ml/hr        no           Sm_Int       
<P> Q_BC_SI_HU      10120        eps          inf          ml/hr        no           Sm_Int       
# Human : Skin
<P> V_TOT_SK_HU     3408         eps          inf          ml           no           Skin         
<P> V_PL_SK_HU      127          eps          inf          ml           no           Skin         
<P> V_BC_SK_HU      104          eps          inf          ml           no           Skin         
<P> V_IN_SK_HU      1125         eps          inf          ml           no           Skin         
<P> V_EN_SK_HU      17           eps          inf          ml           no           Skin         
<P> V_CL_SK_HU      2035         eps          inf          ml           no           Skin         
<P> Q_PL_SK_HU      11626        eps          inf          ml/hr        no           Skin         
<P> Q_BC_SK_HU      9512         eps          inf          ml/hr        no           Skin         
# Human : Spleen
<P> V_TOT_SP_HU     221          eps          inf          ml           no           Spleen       
<P> V_PL_SP_HU      26.8         eps          inf          ml           no           Spleen       
<P> V_BC_SP_HU      21.9         eps          inf          ml           no           Spleen       
<P> V_IN_SP_HU      44.3         eps          inf          ml           no           Spleen       
<P> V_EN_SP_HU      1.11         eps          inf          ml           no           Spleen       
<P> V_CL_SP_HU      127          eps          inf          ml           no           Spleen       
<P> Q_PL_SP_HU      6343         eps          inf          ml/hr        no           Spleen       
<P> Q_BC_SP_HU      5189         eps          inf          ml/hr        no           Spleen       
# Human : Thymus
<P> V_TOT_TH_HU     6.41         eps          inf          ml           no           Thymus       
<P> V_PL_TH_HU      0.353        eps          inf          ml           no           Thymus       
<P> V_BC_TH_HU      0.288        eps          inf          ml           no           Thymus       
<P> V_IN_TH_HU      1.09         eps          inf          ml           no           Thymus       
<P> V_EN_TH_HU      0.0321       eps          inf          ml           no           Thymus       
<P> V_CL_TH_HU      4.65         eps          inf          ml           no           Thymus       
<P> Q_PL_TH_HU      353          eps          inf          ml/hr        no           Thymus       
<P> Q_BC_TH_HU      289          eps          inf          ml/hr        no           Thymus       
# Human : Total
<P> V_TOT_TOT_HU    68498.4      eps          inf          ml           no           Total        
<P> V_PL_TOT_HU     1713.94      eps          inf          ml           no           Total        
<P> V_BC_TOT_HU     1400.83      eps          inf          ml           no           Total        
<P> V_IN_TOT_HU     11360.4      eps          inf          ml           no           Total        
<P> V_EN_TOT_HU     342.05       eps          inf          ml           no           Total        
<P> V_CL_TOT_HU     53682.4      eps          inf          ml           no           Total        
<P> Q_PL_TOT_HU     360157       eps          inf          ml/hr        no           Total        
<P> Q_BC_TOT_HU     294673       eps          inf          ml/hr        no           Total        
<PSET:default> Human
<PSET:MO>Mouse
<PSET:MO:EN_SP_HU>   0
<PSET:MO:EN_SP_MO>   1
<PSET:RA>Rat
<PSET:RA:EN_SP_HU>   0
<PSET:RA:EN_SP_RA>   1
<PSET:RH>Rhesus
<PSET:RH:EN_SP_HU>   0
<PSET:RH:EN_SP_RH>   1

# 
# Covariates
# ---------
# For running simulations, we create covariates that are assocaited with the
# default parameter set
# #     name      times/values  values   units
#   <CV:cvname>  ; times;      [ 0 10];    weeks
#   <CV:cvname>  ; values;     [70 55];    kg     
#
# These can either be interpolated linearly or as step funcitons
# #         name    
#   <CVINTERP:cvname> linear
#   <CVINTERP:cvname> step
#

# Interindividual Variability
# ---------------------------
# <IIV:ETANAME>    0.1            # Variance/diagonal element
# <IIV:ETANAME:LN> PNAME          # Lognormal distirbution (LN) applied to parameter PNAME 
# <IIVCOR:ETANAME1:ETANAME2> 0.01 # Covariance between ETANAME1 and ETANAME2

#
# Alernate Paramter Sets
# ----------------------
#
#<PSET:psetname>       Pset Description
#<PSET:psetname:name>  0.0
#
# By default the covariates will take on the value specified using <CV> above,
# but they can be overwritten at the parameter set level
#   <CVSET:psetname:cvname>  ; times;   [ 0 10]
#   <CVSET:psetname:cvname>  ; values;  [60 55]

# Static Secondary Parameters
#--------------------------------------------=
# Defining parameters for the selected species

# General parameters (like BW) and "liquid" organ parameters (lymph, plasma
# and blood cells)
<As> BW              = SIMINT_SET_SUM[SP][BW_{SP}*EN_SP_{SP}]
<As> BW_R            = SIMINT_SET_SUM[SP][BW_R_{SP}*EN_SP_{SP}]
<As> V_TOT_LN        = SIMINT_SET_SUM[SP][V_TOT_LN_{SP}*EN_SP_{SP}]
<As> V_CL_LN         = SIMINT_SET_SUM[SP][V_CL_LN_{SP}*EN_SP_{SP}]
<As> Q_PL_LN         = SIMINT_SET_SUM[SP][Q_PL_LN_{SP}*EN_SP_{SP}]
<As> Q_BC_LN         = SIMINT_SET_SUM[SP][Q_BC_LN_{SP}*EN_SP_{SP}]
<As> V_TOT_BC        = SIMINT_SET_SUM[SP][V_TOT_BC_{SP}*EN_SP_{SP}]
<As> Q_BC            = SIMINT_SET_SUM[SP][Q_BC_{SP}*EN_SP_{SP}]
<As> V_TOT_PL        = SIMINT_SET_SUM[SP][V_TOT_PL_{SP}*EN_SP_{SP}]
<As> Q_PL            = SIMINT_SET_SUM[SP][Q_PL_{SP}*EN_SP_{SP}]

# Defining the "solid" organ parameters:
<As> {APN}_{ATI} = SIMINT_SET_SUM[SP][{APN}_{ATI}_{SP}*EN_SP_{SP}]


# Defining the other tissue as what remains when the other organs are 
# subtracted from the total

<As> {APN}_OT = {APN}_TOT - SIMINT_SET_SUM[ATI_NO_TOT][{APN}_{ATI_NO_TOT}]
#--------------------------------------------=

# Dynamic Secondary Parameters
# ----------------------------
# <Ad> param_name = right hand side

# #-------------------#
# |Input Information |
# #-------------------#
#
# Bolus Events
# ------------
# # times/events state   values        scale      units
# <B:times>;             [  0  ];      ?;          ???
# <B:events>;      ??;   [1.0  ];      ?;          ???    

# Infusion Rate 
# ------------
# #  name     time/levels  values  scale    units
# <R:name>;    times;     [0  1];     1;    ????
# <R:name>;    levels;    [1  0];     1;    ????
#

# #-----------------------------#
# | ODEs, and State Information |
# #-----------------------------#

# Initial Conditions
# ------------------
# define the non-zero initial conditions
# <I> name = name0

# ODEs
# ----
# <ODE:state> right hand side
<ODE:TMP> 0.0

# Tissue Distribution
# -------------------
# state; compartment_volume; rate  <C> state; compartment_volume; rate

# Rate Equation
# -------------
# state1 + state2 =rate=> state3 + state4

# Equilibrium
# -----------
# state1 + state2 <=rate_forward:rate_reverse=> state3 + state4

# Sources & Sinks
# ---------------
# production/source          elimination/sink
# rate1; rate2      <S:name>  rate3; rate4 

# #---------#
# | Outputs |
# #---------#
# Outputs that begin with QC will not be displayed in the GUI
#
# <O> outputname  = right hand side
<O> TMP_OBS     = 0.0

# #------------#
# | Estimation |
# #------------#
 
# Variance Parameters
# --------------------
#     name       value     lower  upper    units  editable  Label
#                          bound  bound
# <VP> name      -1        eps    inf       --    no        Variance

# Default Dataset
# ---------------
# <DATA:FILE:CSV> data/mydata.csv
# <DATA:HEADER:AUTOMATIC>
# <DATA:HEADER:MANUAL>   col1; col2; col3;

# #---------#
# | Options #
# #---------#

# General Options:
# specify different time scales
<TS:hours> 1.0
ling factor

# Specify the index of state 'name' to be 'number' in the different targets
# <INDEX:STATE:name> number
# 
# Specify the index of output 'name' to be 'number' in the different targets
# <INDEX:OUTPUT:name> number

# Only relevant in Matlab and R
# -----------------------------
# Output Times  
# <OPT:output_times> SIMINT_SEQ[0][100][1]
# default time scale
# <OPT:TS>  name                            
# <OPT:ylim>  [ymin ymax]
# <OPT:ylim>  [ymin ymax]
#

# <AMTIFY> CONC; AMT; REL

# NONMEM options:
# <NONMEM:INPUT:DROP:dataset_column_name>
# <NONMEM:INPUT:RENAME:dataset_column_name> new_column_name

# Adapt Options
# Variance Model      
# --------------
# <VE:OUTPUT> expression
# <VE:OUTPUT>   Slope*SIMINT_POWER[PRED][2.0]