Probably relates to open issue #419
Also tracking on wordpress forums http://wordpress.org/support/topic/plugin-mediaelementjs-html5-video-audio-player-not-working-in-ie8
The plugin causes the entire page to become unresponsive often requiring the tab to be killed. Tried with and without html5shim without effect.
Example here : http://thetwistedgroove.com
Hey there! Cleaning up older issues on the project. Can you reopen this if it's still an active problem for you on the latest version of ME.js? Thanks!