An evidence-based, open-source treatment calculator and educational resource for Peyronie's Disease (Induratio Penis Plastica) multimodal antioxidant therapy. This project compiles extensive research on therapeutic compounds, their synergistic interactions, and personalized dosing protocols based on patient factors and disease stage.
🌐 Live Site: https://ipp-treatment.fyi
📂 GitHub Repository: https://github.com/krugismo/ipp-treatment-fyi
This project aims to:
- Provide an educational resource for patients and healthcare providers
- Calculate personalized therapeutic dosing based on individual patient factors
- Demonstrate synergistic interactions between treatment components
- Compile and organize scientific literature in an accessible format
- Foster open collaboration in non-surgical treatment approaches
- Interactive Pathway Visualization: Visual representation of oxidative stress cascades and therapeutic interventions
- Personalized Calculator: Dosing recommendations based on weight, age, kidney/liver function, and disease stage
- 21 Therapeutic Components: Comprehensive database of compounds with pharmacokinetic/pharmacodynamic properties
- Synergy Analysis: Documented interactions between treatment components
- Literature References: Extensive citation database supporting all therapeutic claims
- Stage-Specific Protocols: Tailored approaches for acute, chronic, calcified, and severe presentations
/data
├── components.json # Therapeutic compounds database
├── interactions.json # Synergistic interactions matrix
├── stages.json # Stage-specific protocols
└── citations.json # Scientific literature references
/js
├── calculator.js # Main calculation engine
├── dosing.js # Dosing algorithms
├── interactions.js # Synergy calculations
└── validation.js # Input validation
Contributions are welcome! Priority areas for development:
- Genetic variant integration (SOD2, GSTM1/GSTT1, GPX1, etc.)
- Environmental factor quantification
- Metabolic biomarker correlations
- Circadian rhythm optimization
- Progress tracking methodology
- Export functionality for treatment protocols
- Anonymized outcome data collection framework
- LLM-ready literature compilation for chatbot integration
- Fork the repository
- Create a feature branch
- Ensure all additions are supported by peer-reviewed literature
- Submit a pull request with citation references
IMPORTANT: This information is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making treatment decisions. Individual results may vary significantly based on numerous factors.
This compilation would not be possible without the dedicated work of countless researchers, clinicians, and practitioners who have contributed to our understanding of Peyronie's Disease and oxidative stress pathology. Special recognition to those pioneering multimodal therapeutic approaches and publishing case studies that challenge conventional treatment paradigms.
Custom Non-Commercial Open Source License
Copyright (c) 2024 IPP Treatment Calculator Project
NON-COMMERCIAL USE ONLY
Permission is hereby granted, free of charge, to any person or organization obtaining a copy of this software and associated documentation files (the "Software"), to use, copy, modify, merge, publish, and distribute the Software for NON-COMMERCIAL PURPOSES ONLY, subject to the following conditions:
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Non-Commercial Use: The Software may be used freely for:
- Personal use
- Educational purposes
- Academic research
- Non-profit healthcare initiatives
- Open source projects that maintain this same non-commercial restriction
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Commercial Use Prohibited: Any use of the Software or its derivatives for commercial purposes is STRICTLY PROHIBITED. This includes but is not limited to:
- Selling the Software or any derivative works
- Using the Software in commercial products or services
- Charging fees for access to the Software or its functionality
- Using the Software to generate revenue in any form
- Incorporating the Software into proprietary commercial solutions
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No Sub-licensing for Commercial Use: Recipients of the Software may NOT grant commercial licenses to third parties. Any redistribution must maintain these same non-commercial restrictions.
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Attribution: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.
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Legal Action: Any violation of these terms, particularly any attempt to commercialize this Software or its derivatives, will result in immediate legal action. Commercial use constitutes copyright infringement and breach of license terms.
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
NOTICE: This is a custom license designed to protect patient-driven medical research from commercial exploitation while maximizing benefit for patients and non-profit medical advancement. For any questions regarding use cases, please contact: ipp-report@proton.me
For corrections, errors, or suggestions: ipp-report@proton.me
If you use this resource in research or clinical practice, please cite:
IPP Treatment Calculator - Multimodal Antioxidant Therapy Protocol. (2024).
Available at: https://ipp-treatment.fyi
peyronies-disease medical-calculator antioxidant-therapy oxidative-stress fibrosis tgf-beta multimodal-therapy personalized-medicine open-source non-commercial patient-advocacy medical-education treatment-protocol pharmacokinetics drug-interactions evidence-based-medicine javascript json web-application health-tech
- Frontend: HTML5, CSS3, JavaScript (ES6+)
- Data Format: JSON for medical data storage
- Visualization: Canvas API for pathway diagrams
- Architecture: Modular JavaScript with separation of concerns
- No Backend Required: Runs entirely in the browser
- No Dependencies: Pure vanilla JavaScript, no frameworks needed
- 21 Therapeutic Components
- 100+ Drug Interactions Documented
- 500+ Scientific References
- 4 Disease Stage Protocols
- 6-48 Month Treatment Duration Range
- Clone the repository:
git clone https://github.com/krugismo/ipp-treatment-fyi.git-
Open
index.htmlin a modern web browser -
No installation or build process required!
If you find this project helpful, please consider giving it a star ⭐ on GitHub to help others discover it.
Made with ❤️ by a patient, for patients
Democratizing medical knowledge through open source