Port 49, 50, 51 are active. Debug logger is turned on. 

----------- code
from netmiko import ConnectHandler

def run_debug_config(config_commands):
    net_connect = ConnectHandler(device_type='cisco_nxos_ssh', ip='xxx', username='admin',
                                 password='xxx', 
                                 global_delay_factor=4, blocking_timeout=40)
    print(config_commands)
    output = net_connect.send_config_set(config_commands, cmd_verify=False)
    net_connect.disconnect()

config_commands = ['int Ethernet1/48', 'no channel-group', 'no switchport', 'switchport',
                   'int Ethernet1/49', 'no channel-group', 'no switchport', 'switchport',
                   'int Ethernet1/50', 'no channel-group', 'no switchport', 'switchport',
                   'int Ethernet1/51', 'no channel-group', 'no switchport', 'switchport']
run_debug_config(config_commands)

----------- output    
read_channel: 
Cisco Nexus Operating System (NX-OS) Software
TAC support: http://www.cisco.com/tac
Copyright (C) 2002-2019, Cisco and/or its affiliates.
All rights reserved.
The copyrights to certain works contained in this software are
owned by other third parties and used and distributed under their own
licenses, such as open source.  This software is provided "as is," and unless
otherwise stated, there is no warranty, express or implied, including but not
limited to warranties of merchantability and fitness for a particular purpose.
Certain components of this software are licensed under
the GNU General Public License (GPL) version 2.0 or 
GNU General Public License (GPL) version 3.0  or the GNU
Lesser General Public License (LGPL) Version 2.1 or 
Lesser General Public License (LGPL) Version 2.0. 
A copy of each such license is available at
http://www.opensource.org/licenses/gpl-2.0.php and
http://opensource.org/licenses/gpl-3.0.html and
http://www.opensource.org/licenses/lgpl-2.1.php and
http://www.gnu.org/licenses/old-licenses/library.txt.
R1-93180YC-EX-A# 
read_channel: 
read_channel: 
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
write_channel: b'\n'
In strip_ansi_escape_codes
repr = '\r\r\n\rR1-93180YC-EX-A# '
Stripping ANSI escape codes
R1-93180YC-EX-A# 
repr = '\r\r\n\rR1-93180YC-EX-A# '
R1-93180YC-EX-A# 
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
[find_prompt()]: prompt is R1-93180YC-EX-A#
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
In disable_paging
Command: terminal length 0
write_channel: b'terminal length 0\n'
Pattern is: terminal\ length\ 0
In strip_ansi_escape_codes
repr = 'terminal length 0\r\r\n'
Stripping ANSI escape codes
repr = 'terminal length 0\r\r\n'
Exiting disable_paging
write_channel: b'terminal width 511\n'
Pattern is: terminal\ width\ 511
In strip_ansi_escape_codes
repr = '\rR1-93180YC-EX-A# '
Stripping ANSI escape codes
R1-93180YC-EX-A# 
repr = '\rR1-93180YC-EX-A# '
R1-93180YC-EX-A# 
In strip_ansi_escape_codes
repr = 'terminal width 511\r\r\n\rR1-93180YC-EX-A# '
Stripping ANSI escape codes
R1-93180YC-EX-A# 
repr = 'terminal width 511\r\r\n\rR1-93180YC-EX-A# '
R1-93180YC-EX-A# 
R1-93180YC-EX-A# 
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
['int Ethernet1/48',
 'no channel-group',
 'no switchport',
 'switchport',
 'int Ethernet1/49',
 'no channel-group',
 'no switchport',
 'switchport',
 'int Ethernet1/50',
 'no channel-group',
 'no switchport',
 'switchport',
 'int Ethernet1/51',
 'no channel-group',
 'no switchport',
 'switchport']
write_channel: b'\n'
Pattern is: #
In strip_ansi_escape_codes
repr = '\r\r\n\rR1-93180YC-EX-A# '
Stripping ANSI escape codes
R1-93180YC-EX-A# 
repr = '\r\r\n\rR1-93180YC-EX-A# '
R1-93180YC-EX-A# 
R1-93180YC-EX-A# 
write_channel: b'config term\n'
Pattern is: config\ term
In strip_ansi_escape_codes
repr = 'config term\r\r\n'
Stripping ANSI escape codes
repr = 'config term\r\r\n'
Pattern is: R1\-93180YC\-EX\-A
In strip_ansi_escape_codes
repr = 'Enter configuration commands, one per line. End with CNTL/Z.\r\n\rR1-93180YC-EX-A(config)# '
Stripping ANSI escape codes
new_output = Enter configuration commands, one per line. End with CNTL/Z.
R1-93180YC-EX-A(config)# 
repr = 'Enter configuration commands, one per line. End with CNTL/Z.\r\n\rR1-93180YC-EX-A(config)# '
_read_channel_expect read_data: Enter configuration commands, one per line. End with CNTL/Z.
R1-93180YC-EX-A(config)# 
Pattern found: R1\-93180YC\-EX\-A Enter configuration commands, one per line. End with CNTL/Z.
R1-93180YC-EX-A(config)# 
write_channel: b'\n'
Pattern is: #
In strip_ansi_escape_codes
repr = '\r\r\n\rR1-93180YC-EX-A(config)# '
Stripping ANSI escape codes
R1-93180YC-EX-A(config)# 
repr = '\r\r\n\rR1-93180YC-EX-A(config)# '
R1-93180YC-EX-A(config)# 
R1-93180YC-EX-A(config)# 
write_channel: b'int Ethernet1/48\n'
write_channel: b'no channel-group\n'
write_channel: b'no switchport\n'
write_channel: b'switchport\n'
write_channel: b'int Ethernet1/49\n'
write_channel: b'no channel-group\n'
write_channel: b'no switchport\n'
write_channel: b'switchport\n'
write_channel: b'int Ethernet1/50\n'
write_channel: b'no channel-group\n'
write_channel: b'no switchport\n'
write_channel: b'switchport\n'
write_channel: b'int Ethernet1/51\n'
write_channel: b'no channel-group\n'
write_channel: b'no switchport\n'
write_channel: b'switchport\n'
In strip_ansi_escape_codes
repr = 'int Ethernet1/48\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\n\rR1-93180YC-EX-A(config-if)# int Ethernet1/49\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\nswitchport\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\nint Ethernet1/50\r\nno channel-group\r\nno switchport\r\nswitchport\r\nint Ethernet1/51\r\n\rR1-93180YC-EX-A(config-if)# int Ethernet1/50\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\nno channel-group\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\nno switchport\r\n'
Stripping ANSI escape codes
switchport
int Ethernet1/50
no channel-group
no switchport
switchport
int Ethernet1/51
no channel-group
no switchport
repr = 'int Ethernet1/48\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\n\rR1-93180YC-EX-A(config-if)# int Ethernet1/49\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\nswitchport\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\nint Ethernet1/50\r\nno channel-group\r\nno switchport\r\nswitchport\r\nint Ethernet1/51\r\n\rR1-93180YC-EX-A(config-if)# int Ethernet1/50\r\r\n\rR1-93180YC-EX-A(config-if)# no channel-group\r\r\n\rR1-93180YC-EX-A(config-if)# no switchport\r\r\nno channel-group\r\n\rR1-93180YC-EX-A(config-if)# switchport\r\r\nno switchport\r\n'
switchport
int Ethernet1/50
no channel-group
no switchport
switchport
int Ethernet1/51
no channel-group
no switchport
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
In strip_ansi_escape_codes
repr = ''
Stripping ANSI escape codes
new_output = 
repr = ''
read_channel: 
write_channel: b'\n'
Pattern is: #
Socket exception: An existing connection was forcibly closed by the remote host (10054)
Traceback (most recent call last):
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\IPython\core\interactiveshell.py", line 3331, in run_code
    exec(code_obj, self.user_global_ns, self.user_ns)
  File "<ipython-input-11-16680892bd42>", line 24, in <module>
    run_debug_config(config_commands)
  File "<ipython-input-11-16680892bd42>", line 14, in run_debug_config
    output = net_connect.send_config_set(config_commands, cmd_verify=False)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\base_connection.py", line 1770, in send_config_set
    output += self.exit_config_mode()
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\cisco_base_connection.py", line 44, in exit_config_mode
    return super().exit_config_mode(exit_config=exit_config, pattern=pattern)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\base_connection.py", line 1642, in exit_config_mode
    if self.check_config_mode():
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\cisco\cisco_nxos_ssh.py", line 28, in check_config_mode
    return super().check_config_mode(check_string=check_string, pattern=pattern)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\cisco_base_connection.py", line 30, in check_config_mode
    return super().check_config_mode(check_string=check_string, pattern=pattern)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\base_connection.py", line 1606, in check_config_mode
    output = self.read_until_pattern(pattern=pattern)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\base_connection.py", line 627, in read_until_pattern
    return self._read_channel_expect(*args, **kwargs)
  File "C:\Users\lzhao\AppData\Local\Programs\Python\Python37\lib\site-packages\netmiko\base_connection.py", line 552, in _read_channel_expect
    raise EOFError("Channel stream closed by remote device.")
EOFError: Channel stream closed by remote device.