diff --git a/cmd/daemon/cniserver.go b/cmd/daemon/cniserver.go
index db3195234d3..eedfe723df1 100644
--- a/cmd/daemon/cniserver.go
+++ b/cmd/daemon/cniserver.go
@@ -31,6 +31,10 @@ func CmdMain() {
 	daemon.InitMetrics()
 	util.InitKlogMetrics()
 
+	if err := initForOS(); err != nil {
+		util.LogFatalAndExit(err, "failed to do the OS initialization")
+	}
+
 	nicBridgeMappings, err := daemon.InitOVSBridges()
 	if err != nil {
 		util.LogFatalAndExit(err, "failed to initialize OVS bridges")
diff --git a/cmd/daemon/init.go b/cmd/daemon/init.go
new file mode 100644
index 00000000000..bf094065afd
--- /dev/null
+++ b/cmd/daemon/init.go
@@ -0,0 +1,22 @@
+//go:build !windows
+// +build !windows
+
+package daemon
+
+import (
+	"fmt"
+	"os/exec"
+
+	"k8s.io/klog/v2"
+)
+
+func initForOS() error {
+	// disable checksum for genev_sys_6081 as default
+	cmd := exec.Command("sh", "-c", "ethtool -K genev_sys_6081 tx off")
+	if err := cmd.Run(); err != nil {
+		err := fmt.Errorf("failed to set checksum off for genev_sys_6081, %v", err)
+		// should not affect cni pod running if failed, just record err log
+		klog.Error(err)
+	}
+	return nil
+}