diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3287d6bc4c..49f3e07dec 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,6 +1,7 @@
 ## Cairo-VM Changelog
 
 #### Upcoming Changes
+* fix: Handle the deserialization of serde_json::Number with scientific notation (e.g.: Number(1e27)) in felt_from_number function [#1188](https://github.com/lambdaclass/cairo-rs/pull/1188)
 
 * bugfix: Use cairo constants in `ASSERT_250_BIT` hint [#1187](https://github.com/lambdaclass/cairo-rs/pull/1187)
 
diff --git a/src/serde/deserialize_program.rs b/src/serde/deserialize_program.rs
index ef1e161df4..ecf0cdf862 100644
--- a/src/serde/deserialize_program.rs
+++ b/src/serde/deserialize_program.rs
@@ -16,7 +16,7 @@ use crate::{
     },
 };
 use felt::{Felt252, PRIME_STR};
-use num_traits::Num;
+use num_traits::{Num, Pow};
 use serde::{de, de::MapAccess, de::SeqAccess, Deserialize, Deserializer, Serialize};
 use serde_json::Number;
 
@@ -167,10 +167,32 @@ where
     let n = Number::deserialize(deserializer)?;
     match Felt252::parse_bytes(n.to_string().as_bytes(), 10) {
         Some(x) => Ok(Some(x)),
-        None => Err(String::from("felt_from_number parse error")).map_err(de::Error::custom),
+        None => {
+            // Handle de Number with scientific notation cases
+            // e.g.: n = Number(1e27)
+            let felt = deserialize_scientific_notation(n);
+            if felt.is_some() {
+                return Ok(felt);
+            }
+
+            Err(de::Error::custom(String::from(
+                "felt_from_number parse error",
+            )))
+        }
     }
 }
 
+fn deserialize_scientific_notation(n: Number) -> Option<Felt252> {
+    let str = n.to_string();
+    let list: [&str; 2] = str.split('e').collect::<Vec<&str>>().try_into().ok()?;
+
+    let base = Felt252::parse_bytes(list[0].to_string().as_bytes(), 10)?;
+    let exponent = list[1].parse::<u32>().ok()?;
+
+    let result = base * Felt252::from(10).pow(exponent);
+    Some(result)
+}
+
 #[derive(Serialize, Deserialize, Debug, PartialEq, Eq, Clone)]
 pub struct ReferenceManager {
     pub references: Vec<Reference>,
@@ -421,6 +443,7 @@ mod tests {
     use super::*;
     use assert_matches::assert_matches;
     use felt::felt_str;
+    use num_traits::One;
     use num_traits::Zero;
 
     #[cfg(target_arch = "wasm32")]
@@ -1363,4 +1386,17 @@ mod tests {
         let iden: Result<Identifier, serde_json::Error> = serde_json::from_str(valid_json);
         assert!(iden.err().is_some());
     }
+
+    #[test]
+    #[cfg_attr(target_arch = "wasm32", wasm_bindgen_test)]
+    fn test_felt_from_number_with_scientific_notation() {
+        let n = Number::deserialize(serde_json::Value::from(1000000000000000000000000000_u128))
+            .unwrap();
+        assert_eq!(n.to_string(), "1e27".to_owned());
+
+        assert_matches!(
+            felt_from_number(n),
+            Ok(x) if x == Some(Felt252::one() * Felt252::from(10).pow(27))
+        );
+    }
 }