Data and code repository for spike-in normalization comment.
Code for generating Figures:
Figure 1: Benchmarking Spike-in Normalization
Figure 1a: Re-analysis of Orlando et al. 2014 dataset
Figure 1b: Titration of H3K9ac with mitotic and interphase cells
Figure 3: Analysis of spike-in variability across public datasets
Figure 4: An example of the ability of proper normalization strategy to correct for variations in the spike-in/sample ratio
Overall pipeline for analysis of data is below:
