diff --git a/Cargo.toml b/Cargo.toml
index d01f3307eb..41d05245c6 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -146,6 +146,10 @@ url = "2.2.2"
 rand = "0.8.4"
 rand_xoshiro = "0.6.0"
 hex = "0.4.3"
+tempdir = "0.3.7"
+# Needed to test SQLCipher
+libsqlite3-sys = { version = "*", features = ["bundled-sqlcipher"] }
+
 #
 # Any
 #
@@ -198,6 +202,11 @@ name = "sqlite-derives"
 path = "tests/sqlite/derives.rs"
 required-features = ["sqlite", "macros"]
 
+[[test]]
+name = "sqlcipher"
+path = "tests/sqlite/sqlcipher.rs"
+required-features = ["sqlite"]
+
 [[test]]
 name = "sqlite-test-attr"
 path = "tests/sqlite/test-attr.rs"
diff --git a/sqlx-core/src/sqlite/options/mod.rs b/sqlx-core/src/sqlite/options/mod.rs
index d5ec65c271..2e21bf5590 100644
--- a/sqlx-core/src/sqlite/options/mod.rs
+++ b/sqlx-core/src/sqlite/options/mod.rs
@@ -102,6 +102,42 @@ impl SqliteConnectOptions {
         // SQLCipher special case: if the `key` pragma is set, it must be executed first.
         pragmas.insert("key".into(), None);
 
+        // Other SQLCipher pragmas that has to be after the key, but before any other operation on the database.
+        // https://www.zetetic.net/sqlcipher/sqlcipher-api/
+
+        // Bytes of the database file that is not encrypted
+        // Default for SQLCipher v4 is 0
+        // If greater than zero 'cipher_salt' pragma must be also defined
+        pragmas.insert("cipher_plaintext_header_size".into(), None);
+
+        // Allows to provide salt manually
+        // By default SQLCipher sets salt automatically, use only in conjunction with
+        // 'cipher_plaintext_header_size' pragma
+        pragmas.insert("cipher_salt".into(), None);
+
+        // Number of iterations used in PBKDF2 key derivation.
+        // Default for SQLCipher v4 is 256000
+        pragmas.insert("kdf_iter".into(), None);
+
+        // Define KDF algorithm to be used.
+        // Default for SQLCipher v4 is PBKDF2_HMAC_SHA512.
+        pragmas.insert("cipher_kdf_algorithm".into(), None);
+
+        // Enable or disable HMAC functionality.
+        // Default for SQLCipher v4 is 1.
+        pragmas.insert("cipher_use_hmac".into(), None);
+
+        // Set default encryption settings depending on the version 1,2,3, or 4.
+        pragmas.insert("cipher_compatibility".into(), None);
+
+        // Page size of encrypted database.
+        // Default for SQLCipher v4 is 4096.
+        pragmas.insert("cipher_page_size".into(), None);
+
+        // Choose algorithm used for HMAC.
+        // Default for SQLCipher v4 is HMAC_SHA512.
+        pragmas.insert("cipher_hmac_algorithm".into(), None);
+
         // Normally, page_size must be set before any other action on the database.
         // Defaults to 4096 for new databases.
         pragmas.insert("page_size".into(), None);
@@ -284,9 +320,9 @@ impl SqliteConnectOptions {
     /// Note this excerpt:
     /// > The collating function must obey the following properties for all strings A, B, and C:
     /// >
-    /// > If A==B then B==A.  
-    /// > If A==B and B==C then A==C.  
-    /// > If A\<B then B>A.  
+    /// > If A==B then B==A.
+    /// > If A==B and B==C then A==C.
+    /// > If A\<B then B>A.
     /// > If A<B and B<C then A<C.
     /// >
     /// > If a collating function fails any of the above constraints and that collating function is
@@ -328,7 +364,7 @@ impl SqliteConnectOptions {
     /// ### Note
     /// Setting this to `true` may help if you are getting access violation errors or segmentation
     /// faults, but will also incur a significant performance penalty. You should leave this
-    /// set to `false` if at all possible.    
+    /// set to `false` if at all possible.
     ///
     /// If you do end up needing to set this to `true` for some reason, please
     /// [open an issue](https://github.com/launchbadge/sqlx/issues/new/choose) as this may indicate
diff --git a/tests/sqlite/sqlcipher.rs b/tests/sqlite/sqlcipher.rs
new file mode 100644
index 0000000000..0a2a4499ea
--- /dev/null
+++ b/tests/sqlite/sqlcipher.rs
@@ -0,0 +1,202 @@
+use std::str::FromStr;
+
+use sqlx::sqlite::SqliteQueryResult;
+use sqlx::{query, Connection, SqliteConnection};
+use sqlx::{sqlite::SqliteConnectOptions, ConnectOptions};
+use sqlx_rt::fs::File;
+use tempdir::TempDir;
+
+async fn new_db_url() -> anyhow::Result<(String, TempDir)> {
+    let dir = TempDir::new("sqlcipher_test")?;
+    let filepath = dir.path().join("database.sqlite3");
+
+    // Touch the file, so DB driver will not complain it does not exist
+    File::create(filepath.as_path()).await?;
+
+    Ok((format!("sqlite://{}", filepath.display()), dir))
+}
+
+async fn fill_db(conn: &mut SqliteConnection) -> anyhow::Result<SqliteQueryResult> {
+    conn.transaction(|tx| {
+        Box::pin(async move {
+            query(
+                "
+                CREATE TABLE Company(
+                    Id INT PRIMARY KEY     NOT NULL,
+                    Name           TEXT    NOT NULL,
+                    Salary         REAL
+                 );
+                 ",
+            )
+            .execute(&mut *tx)
+            .await?;
+
+            query(
+                r#"
+                INSERT INTO Company(Id, Name, Salary)
+                VALUES
+                    (1, "aaa", 111),
+                    (2, "bbb", 222)
+                "#,
+            )
+            .execute(tx)
+            .await
+        })
+    })
+    .await
+    .map_err(|e| e.into())
+}
+
+#[sqlx_macros::test]
+async fn it_encrypts() -> anyhow::Result<()> {
+    let (url, _dir) = new_db_url().await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    fill_db(&mut conn).await?;
+
+    // Create another connection without key, query should fail
+    let mut conn = SqliteConnectOptions::from_str(&url)?.connect().await?;
+
+    assert!(conn
+        .transaction(|tx| {
+            Box::pin(async move { query("SELECT * FROM Company;").fetch_all(tx).await })
+        })
+        .await
+        .is_err());
+
+    Ok(())
+}
+
+#[sqlx_macros::test]
+async fn it_can_store_and_read_encrypted_data() -> anyhow::Result<()> {
+    let (url, _dir) = new_db_url().await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    fill_db(&mut conn).await?;
+
+    // Create another connection with valid key
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    let result = conn
+        .transaction(|tx| {
+            Box::pin(async move { query("SELECT * FROM Company;").fetch_all(tx).await })
+        })
+        .await?;
+
+    assert!(result.len() > 0);
+
+    Ok(())
+}
+
+#[sqlx_macros::test]
+async fn it_fails_if_password_is_incorrect() -> anyhow::Result<()> {
+    let (url, _dir) = new_db_url().await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    fill_db(&mut conn).await?;
+
+    // Connection with invalid key should not allow to execute queries
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "BADBADBAD")
+        .connect()
+        .await?;
+
+    assert!(conn
+        .transaction(|tx| {
+            Box::pin(async move { query("SELECT * FROM Company;").fetch_all(tx).await })
+        })
+        .await
+        .is_err());
+
+    Ok(())
+}
+
+#[sqlx_macros::test]
+async fn it_honors_order_of_encryption_pragmas() -> anyhow::Result<()> {
+    let (url, _dir) = new_db_url().await?;
+
+    // Make call of cipher configuration mixed with other pragmas,
+    // it should have no effect, encryption related pragmas should be
+    // executed first and allow to establish valid connection
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("cipher_kdf_algorithm", "PBKDF2_HMAC_SHA1")
+        .journal_mode(sqlx::sqlite::SqliteJournalMode::Wal)
+        .pragma("cipher_page_size", "1024")
+        .pragma("key", "the_password")
+        .foreign_keys(true)
+        .pragma("kdf_iter", "64000")
+        .auto_vacuum(sqlx::sqlite::SqliteAutoVacuum::Incremental)
+        .pragma("cipher_hmac_algorithm", "HMAC_SHA1")
+        .connect()
+        .await?;
+
+    fill_db(&mut conn).await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("dummy", "pragma")
+        // The cipher configuration set on first connection is
+        // version 3 of SQLCipher, so for second it's enough to set
+        // the compatibility mode.
+        .pragma("cipher_compatibility", "3")
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    let result = conn
+        .transaction(|tx| {
+            Box::pin(async move { query("SELECT * FROM COMPANY;").fetch_all(tx).await })
+        })
+        .await?;
+
+    assert!(result.len() > 0);
+
+    Ok(())
+}
+
+#[sqlx_macros::test]
+async fn it_allows_to_rekey_the_db() -> anyhow::Result<()> {
+    let (url, _dir) = new_db_url().await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("key", "the_password")
+        .connect()
+        .await?;
+
+    fill_db(&mut conn).await?;
+
+    // The 'pragma rekey' can be called at any time
+    query("PRAGMA rekey = new_password;")
+        .execute(&mut conn)
+        .await?;
+
+    let mut conn = SqliteConnectOptions::from_str(&url)?
+        .pragma("dummy", "pragma")
+        .pragma("key", "new_password")
+        .connect()
+        .await?;
+
+    let result = conn
+        .transaction(|tx| {
+            Box::pin(async move { query("SELECT * FROM COMPANY;").fetch_all(tx).await })
+        })
+        .await?;
+
+    assert!(result.len() > 0);
+
+    Ok(())
+}