Consider a WINE plugin

[probonopd]

A plugin to produce WINE-based bundles containing the payload WIndows application, the smallest subset of WINE (similar to what we do for Qt) that is required to run it, and the 32-bit libraries down to ld-linux.so might be interesting.

The resulting bundles could be run on 64-bit Linux machines without the need to install any 32-bit compatibility libraries on the system.

I have laid out a quite elaborated manual process to achieve this at https://github.com/AppImage/AppImageKit/wiki/Bundling-Windows-applications and @Hackerl has just created the missing piece at Hackerl/Wine_Appimage#11.