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 * [Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7](https://www.nature.com/articles/s41586-021-03398-2) unfortunately has worse findings, B.1.351 in particular being worrisome in that this variant is not only refractory to neutralization by most NTD mAbs but also by multiple individual mAbs to the receptor-binding motif on RBD, largely owing to an E484K mutation, and it is very resistant to neutralizatio by both convalescent plasma and sera from people who received the Pfeizer and Moderna vaccines, by around 10 times
 * [FDA-authorized COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system](https://www.medrxiv.org/content/10.1101/2021.02.15.21251623v2) is a preprint that analyzes more than 60000 individuals at Mayo Clinic, dividing them into a vaccinated cohort (with Pfizer/BioNTech or Moderna) and an unvaccinated one, and retrospectively concluding there was 88.7% efficacy in preventing infection, i.e. a positive RT-PCR test at all, and hence likely also contagiousness, as opposed to just symptomatic cases, which was the benchmark of most of the vaccine trials
 * [Single-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00528-6/fulltext#coronavirus-linkback-header) tries to make sense of the confusing dosing issues with the Oxford/Astrazeneca (ChAdOx1) vaccine, and provides some tentative evidence in favor of the UK choice of delaying the booster shot to 12 weeks after the initial shot
+* [AZD1222 US Phase III trial met primary efficacy endpoint in preventing COVID-19 at interim analysis](https://www.astrazeneca.com/content/astraz/media-centre/press-releases/2021/astrazeneca-us-vaccine-trial-met-primary-endpoint.html) in an AstraZeneca press release announcing the US trial found overall 79% efficacy including in 65+ people (who constituted 20% of the trial subjects, and 60% of them had comorbidities), and 100% efficacy in preventing severe disease and hospitalization; AstraZeneca also points out that the specifically monitored for thrombosis in general and [cerebral venous sinus thrombosis](https://en.wikipedia.org/wiki/Cerebral_venous_sinus_thrombosis) (due to the events in Europe) and found no signs of it
 
 #### Moderna (mRNA-1273)