diff --git a/llvm/cmake/modules/HandleLLVMOptions.cmake b/llvm/cmake/modules/HandleLLVMOptions.cmake
index 6119ecdce0f4..78be03d2bc13 100644
--- a/llvm/cmake/modules/HandleLLVMOptions.cmake
+++ b/llvm/cmake/modules/HandleLLVMOptions.cmake
@@ -582,6 +582,16 @@ if ( LLVM_COMPILER_IS_GCC_COMPATIBLE OR CMAKE_CXX_COMPILER_ID MATCHES "XL" )
   add_flag_if_supported("-Werror=unguarded-availability-new" WERROR_UNGUARDED_AVAILABILITY_NEW)
 endif( LLVM_COMPILER_IS_GCC_COMPATIBLE OR CMAKE_CXX_COMPILER_ID MATCHES "XL" )
 
+if ( LLVM_COMPILER_IS_GCC_COMPATIBLE )
+  # LLVM data structures like llvm::User and llvm::MDNode rely on
+  # the value of object storage persisting beyond the lifetime of the
+  # object (#24952).  This is not standard compliant and causes a runtime
+  # crash if LLVM is built with GCC and LTO enabled (#57740).  Until
+  # these bugs are fixed, we need to disable dead store eliminations
+  # based on object lifetime.
+  add_flag_if_supported("-fno-lifetime-dse" CMAKE_CXX_FLAGS)
+endif ( LLVM_COMPILER_IS_GCC_COMPATIBLE )
+
 # Modules enablement for GCC-compatible compilers:
 if ( LLVM_COMPILER_IS_GCC_COMPATIBLE AND LLVM_ENABLE_MODULES )
   set(OLD_CMAKE_REQUIRED_FLAGS ${CMAKE_REQUIRED_FLAGS})