diff --git a/llvm/lib/Target/PowerPC/PPCISelLowering.cpp b/llvm/lib/Target/PowerPC/PPCISelLowering.cpp
index 2f9ff293c2775..42df83831113a 100644
--- a/llvm/lib/Target/PowerPC/PPCISelLowering.cpp
+++ b/llvm/lib/Target/PowerPC/PPCISelLowering.cpp
@@ -15659,7 +15659,8 @@ bool PPCTargetLowering::allowsMisalignedMemoryAccesses(EVT VT,
   if (!VT.isSimple())
     return false;
 
-  if (VT.isFloatingPoint() && !Subtarget.allowsUnalignedFPAccess())
+  if (VT.isFloatingPoint() && !VT.isVector() &&
+      !Subtarget.allowsUnalignedFPAccess())
     return false;
 
   if (VT.getSimpleVT().isVector()) {
diff --git a/llvm/test/CodeGen/PowerPC/pr45186.ll b/llvm/test/CodeGen/PowerPC/pr45186.ll
new file mode 100644
index 0000000000000..92f748e3ef5a3
--- /dev/null
+++ b/llvm/test/CodeGen/PowerPC/pr45186.ll
@@ -0,0 +1,132 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py
+; RUN: llc -ppc-asm-full-reg-names -mtriple=powerpc64-- -mattr=+vsx \
+; RUN:   -verify-machineinstrs < %s | FileCheck %s
+%struct.anon = type { i64, i64 }
+
+@d = local_unnamed_addr global %struct.anon zeroinitializer, align 8
+
+; Function Attrs: norecurse nounwind readonly
+define i64 @e(i8* nocapture readonly %f) local_unnamed_addr #0 {
+; CHECK-LABEL: e:
+; CHECK:       # %bb.0: # %entry
+; CHECK-NEXT:    ldx r3, 0, r3
+; CHECK-NEXT:    blr
+entry:
+  %0 = load i8, i8* %f, align 1
+  %conv = zext i8 %0 to i64
+  %shl = shl nuw i64 %conv, 56
+  %arrayidx1 = getelementptr inbounds i8, i8* %f, i64 1
+  %1 = load i8, i8* %arrayidx1, align 1
+  %conv2 = zext i8 %1 to i64
+  %shl3 = shl nuw nsw i64 %conv2, 48
+  %or = or i64 %shl3, %shl
+  %arrayidx4 = getelementptr inbounds i8, i8* %f, i64 2
+  %2 = load i8, i8* %arrayidx4, align 1
+  %conv5 = zext i8 %2 to i64
+  %shl6 = shl nuw nsw i64 %conv5, 40
+  %or7 = or i64 %or, %shl6
+  %arrayidx8 = getelementptr inbounds i8, i8* %f, i64 3
+  %3 = load i8, i8* %arrayidx8, align 1
+  %conv9 = zext i8 %3 to i64
+  %shl10 = shl nuw nsw i64 %conv9, 32
+  %or11 = or i64 %or7, %shl10
+  %arrayidx12 = getelementptr inbounds i8, i8* %f, i64 4
+  %4 = load i8, i8* %arrayidx12, align 1
+  %conv13 = zext i8 %4 to i64
+  %shl14 = shl nuw nsw i64 %conv13, 24
+  %or15 = or i64 %or11, %shl14
+  %arrayidx16 = getelementptr inbounds i8, i8* %f, i64 5
+  %5 = load i8, i8* %arrayidx16, align 1
+  %conv17 = zext i8 %5 to i64
+  %shl18 = shl nuw nsw i64 %conv17, 16
+  %or20 = or i64 %or15, %shl18
+  %arrayidx21 = getelementptr inbounds i8, i8* %f, i64 6
+  %6 = load i8, i8* %arrayidx21, align 1
+  %conv22 = zext i8 %6 to i64
+  %shl23 = shl nuw nsw i64 %conv22, 8
+  %or25 = or i64 %or20, %shl23
+  %arrayidx26 = getelementptr inbounds i8, i8* %f, i64 7
+  %7 = load i8, i8* %arrayidx26, align 1
+  %conv27 = zext i8 %7 to i64
+  %or28 = or i64 %or25, %conv27
+  ret i64 %or28
+}
+
+; Function Attrs: nofree norecurse nounwind
+define void @g() local_unnamed_addr #0 {
+; CHECK-LABEL: g:
+; CHECK:       # %bb.0: # %entry
+; CHECK-NEXT:    addis r3, r2, .LC0@toc@ha
+; CHECK-NEXT:    addis r4, r2, .LC1@toc@ha
+; CHECK-NEXT:    ld r3, .LC0@toc@l(r3)
+; CHECK-NEXT:    ld r4, .LC1@toc@l(r4)
+; CHECK-NEXT:    lxvd2x vs0, 0, r3
+; CHECK-NEXT:    stxvd2x vs0, 0, r4
+; CHECK-NEXT:    blr
+entry:
+  %0 = load i8, i8* getelementptr inbounds (i8, i8* bitcast (void ()* @g to i8*), i64 8), align 1
+  %conv.i = zext i8 %0 to i64
+  %shl.i = shl nuw i64 %conv.i, 56
+  %1 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 9), align 1
+  %conv2.i = zext i8 %1 to i64
+  %shl3.i = shl nuw nsw i64 %conv2.i, 48
+  %or.i = or i64 %shl3.i, %shl.i
+  %2 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 10), align 1
+  %conv5.i = zext i8 %2 to i64
+  %shl6.i = shl nuw nsw i64 %conv5.i, 40
+  %or7.i = or i64 %or.i, %shl6.i
+  %3 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 11), align 1
+  %conv9.i = zext i8 %3 to i64
+  %shl10.i = shl nuw nsw i64 %conv9.i, 32
+  %or11.i = or i64 %or7.i, %shl10.i
+  %4 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 12), align 1
+  %conv13.i = zext i8 %4 to i64
+  %shl14.i = shl nuw nsw i64 %conv13.i, 24
+  %or15.i = or i64 %or11.i, %shl14.i
+  %5 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 13), align 1
+  %conv17.i = zext i8 %5 to i64
+  %shl18.i = shl nuw nsw i64 %conv17.i, 16
+  %or20.i = or i64 %or15.i, %shl18.i
+  %6 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 14), align 1
+  %conv22.i = zext i8 %6 to i64
+  %shl23.i = shl nuw nsw i64 %conv22.i, 8
+  %or25.i = or i64 %or20.i, %shl23.i
+  %7 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 15), align 1
+  %conv27.i = zext i8 %7 to i64
+  %or28.i = or i64 %or25.i, %conv27.i
+  store i64 %or28.i, i64* getelementptr inbounds (%struct.anon, %struct.anon* @d, i64 0, i32 1), align 8
+  %8 = load i8, i8* bitcast (void ()* @g to i8*), align 1
+  %conv.i2 = zext i8 %8 to i64
+  %shl.i3 = shl nuw i64 %conv.i2, 56
+  %9 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 1), align 1
+  %conv2.i4 = zext i8 %9 to i64
+  %shl3.i5 = shl nuw nsw i64 %conv2.i4, 48
+  %or.i6 = or i64 %shl3.i5, %shl.i3
+  %10 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 2), align 1
+  %conv5.i7 = zext i8 %10 to i64
+  %shl6.i8 = shl nuw nsw i64 %conv5.i7, 40
+  %or7.i9 = or i64 %or.i6, %shl6.i8
+  %11 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 3), align 1
+  %conv9.i10 = zext i8 %11 to i64
+  %shl10.i11 = shl nuw nsw i64 %conv9.i10, 32
+  %or11.i12 = or i64 %or7.i9, %shl10.i11
+  %12 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 4), align 1
+  %conv13.i13 = zext i8 %12 to i64
+  %shl14.i14 = shl nuw nsw i64 %conv13.i13, 24
+  %or15.i15 = or i64 %or11.i12, %shl14.i14
+  %13 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 5), align 1
+  %conv17.i16 = zext i8 %13 to i64
+  %shl18.i17 = shl nuw nsw i64 %conv17.i16, 16
+  %or20.i18 = or i64 %or15.i15, %shl18.i17
+  %14 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 6), align 1
+  %conv22.i19 = zext i8 %14 to i64
+  %shl23.i20 = shl nuw nsw i64 %conv22.i19, 8
+  %or25.i21 = or i64 %or20.i18, %shl23.i20
+  %15 = load i8, i8* getelementptr (i8, i8* bitcast (void ()* @g to i8*), i64 7), align 1
+  %conv27.i22 = zext i8 %15 to i64
+  %or28.i23 = or i64 %or25.i21, %conv27.i22
+  store i64 %or28.i23, i64* getelementptr inbounds (%struct.anon, %struct.anon* @d, i64 0, i32 0), align 8
+  ret void
+}
+
+attributes #0 = { nounwind }