diff --git a/llvm/test/CodeGen/X86/pr45378.ll b/llvm/test/CodeGen/X86/pr45378.ll
new file mode 100644
index 00000000000000..f6dcf28bff0c86
--- /dev/null
+++ b/llvm/test/CodeGen/X86/pr45378.ll
@@ -0,0 +1,237 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=sse2     | FileCheck %s --check-prefixes=CHECK,SSE,SSE2
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=sse4.1   | FileCheck %s --check-prefixes=CHECK,SSE,SSE41
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=avx      | FileCheck %s --check-prefixes=CHECK,AVX,AVX1OR2,AVX1
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=avx2     | FileCheck %s --check-prefixes=CHECK,AVX,AVX1OR2,AVX2
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=avx512f  | FileCheck %s --check-prefixes=CHECK,AVX,AVX512,AVX512F
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=avx512bw | FileCheck %s --check-prefixes=CHECK,AVX,AVX512,AVX512BW
+
+declare i64 @llvm.experimental.vector.reduce.or.v2i64(<2 x i64>)
+declare void @TrapFunc(i64)
+
+define void @parseHeaders(i64 * %ptr) {
+; SSE2-LABEL: parseHeaders:
+; SSE2:       # %bb.0:
+; SSE2-NEXT:    pushq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 16
+; SSE2-NEXT:    movdqu (%rdi), %xmm1
+; SSE2-NEXT:    pshufd {{.*#+}} xmm0 = xmm1[2,3,0,1]
+; SSE2-NEXT:    por %xmm0, %xmm1
+; SSE2-NEXT:    movq %xmm1, %rax
+; SSE2-NEXT:    testq %rax, %rax
+; SSE2-NEXT:    je .LBB0_2
+; SSE2-NEXT:  # %bb.1: # %trap
+; SSE2-NEXT:    movq %xmm0, %rdi
+; SSE2-NEXT:    callq TrapFunc
+; SSE2-NEXT:  .LBB0_2: # %ret
+; SSE2-NEXT:    popq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 8
+; SSE2-NEXT:    retq
+;
+; SSE41-LABEL: parseHeaders:
+; SSE41:       # %bb.0:
+; SSE41-NEXT:    pushq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 16
+; SSE41-NEXT:    movdqu (%rdi), %xmm0
+; SSE41-NEXT:    pshufd {{.*#+}} xmm1 = xmm0[2,3,0,1]
+; SSE41-NEXT:    por %xmm0, %xmm1
+; SSE41-NEXT:    movq %xmm1, %rax
+; SSE41-NEXT:    testq %rax, %rax
+; SSE41-NEXT:    je .LBB0_2
+; SSE41-NEXT:  # %bb.1: # %trap
+; SSE41-NEXT:    pextrq $1, %xmm0, %rdi
+; SSE41-NEXT:    callq TrapFunc
+; SSE41-NEXT:  .LBB0_2: # %ret
+; SSE41-NEXT:    popq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 8
+; SSE41-NEXT:    retq
+;
+; AVX1-LABEL: parseHeaders:
+; AVX1:       # %bb.0:
+; AVX1-NEXT:    pushq %rax
+; AVX1-NEXT:    .cfi_def_cfa_offset 16
+; AVX1-NEXT:    vmovdqu (%rdi), %xmm0
+; AVX1-NEXT:    vpshufd {{.*#+}} xmm1 = xmm0[2,3,0,1]
+; AVX1-NEXT:    vpor %xmm1, %xmm0, %xmm1
+; AVX1-NEXT:    vmovq %xmm1, %rax
+; AVX1-NEXT:    testq %rax, %rax
+; AVX1-NEXT:    je .LBB0_2
+; AVX1-NEXT:  # %bb.1: # %trap
+; AVX1-NEXT:    vpextrq $1, %xmm0, %rdi
+; AVX1-NEXT:    callq TrapFunc
+; AVX1-NEXT:  .LBB0_2: # %ret
+; AVX1-NEXT:    popq %rax
+; AVX1-NEXT:    .cfi_def_cfa_offset 8
+; AVX1-NEXT:    retq
+;
+; AVX2-LABEL: parseHeaders:
+; AVX2:       # %bb.0:
+; AVX2-NEXT:    pushq %rax
+; AVX2-NEXT:    .cfi_def_cfa_offset 16
+; AVX2-NEXT:    vmovdqu (%rdi), %xmm0
+; AVX2-NEXT:    vpbroadcastq 8(%rdi), %xmm1
+; AVX2-NEXT:    vpor %xmm1, %xmm0, %xmm1
+; AVX2-NEXT:    vmovq %xmm1, %rax
+; AVX2-NEXT:    testq %rax, %rax
+; AVX2-NEXT:    je .LBB0_2
+; AVX2-NEXT:  # %bb.1: # %trap
+; AVX2-NEXT:    vpextrq $1, %xmm0, %rdi
+; AVX2-NEXT:    callq TrapFunc
+; AVX2-NEXT:  .LBB0_2: # %ret
+; AVX2-NEXT:    popq %rax
+; AVX2-NEXT:    .cfi_def_cfa_offset 8
+; AVX2-NEXT:    retq
+;
+; AVX512-LABEL: parseHeaders:
+; AVX512:       # %bb.0:
+; AVX512-NEXT:    pushq %rax
+; AVX512-NEXT:    .cfi_def_cfa_offset 16
+; AVX512-NEXT:    vmovdqu (%rdi), %xmm0
+; AVX512-NEXT:    vpbroadcastq 8(%rdi), %xmm1
+; AVX512-NEXT:    vpor %xmm1, %xmm0, %xmm1
+; AVX512-NEXT:    vmovq %xmm1, %rax
+; AVX512-NEXT:    testq %rax, %rax
+; AVX512-NEXT:    je .LBB0_2
+; AVX512-NEXT:  # %bb.1: # %trap
+; AVX512-NEXT:    vpextrq $1, %xmm0, %rdi
+; AVX512-NEXT:    callq TrapFunc
+; AVX512-NEXT:  .LBB0_2: # %ret
+; AVX512-NEXT:    popq %rax
+; AVX512-NEXT:    .cfi_def_cfa_offset 8
+; AVX512-NEXT:    retq
+  %vptr = bitcast i64 * %ptr to <2 x i64> *
+  %vload = load <2 x i64>, <2 x i64> * %vptr, align 8
+  %vreduce = call i64 @llvm.experimental.vector.reduce.or.v2i64(<2 x i64> %vload)
+  %vcheck = icmp eq i64 %vreduce, 0
+  br i1 %vcheck, label %ret, label %trap
+trap:
+  %v2 = extractelement <2 x i64> %vload, i32 1
+  call void @TrapFunc(i64 %v2)
+  ret void
+ret:
+  ret void
+}
+
+define void @parseHeaders2_scalar_or(i64 * %ptr) {
+; SSE2-LABEL: parseHeaders2_scalar_or:
+; SSE2:       # %bb.0:
+; SSE2-NEXT:    pushq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 16
+; SSE2-NEXT:    movdqu (%rdi), %xmm0
+; SSE2-NEXT:    movq %xmm0, %rax
+; SSE2-NEXT:    pshufd {{.*#+}} xmm0 = xmm0[2,3,0,1]
+; SSE2-NEXT:    movq %xmm0, %rdi
+; SSE2-NEXT:    orq %rdi, %rax
+; SSE2-NEXT:    je .LBB1_2
+; SSE2-NEXT:  # %bb.1: # %trap
+; SSE2-NEXT:    callq TrapFunc
+; SSE2-NEXT:  .LBB1_2: # %ret
+; SSE2-NEXT:    popq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 8
+; SSE2-NEXT:    retq
+;
+; SSE41-LABEL: parseHeaders2_scalar_or:
+; SSE41:       # %bb.0:
+; SSE41-NEXT:    pushq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 16
+; SSE41-NEXT:    movdqu (%rdi), %xmm0
+; SSE41-NEXT:    ptest %xmm0, %xmm0
+; SSE41-NEXT:    je .LBB1_2
+; SSE41-NEXT:  # %bb.1: # %trap
+; SSE41-NEXT:    pextrq $1, %xmm0, %rdi
+; SSE41-NEXT:    callq TrapFunc
+; SSE41-NEXT:  .LBB1_2: # %ret
+; SSE41-NEXT:    popq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 8
+; SSE41-NEXT:    retq
+;
+; AVX-LABEL: parseHeaders2_scalar_or:
+; AVX:       # %bb.0:
+; AVX-NEXT:    pushq %rax
+; AVX-NEXT:    .cfi_def_cfa_offset 16
+; AVX-NEXT:    vmovdqu (%rdi), %xmm0
+; AVX-NEXT:    vptest %xmm0, %xmm0
+; AVX-NEXT:    je .LBB1_2
+; AVX-NEXT:  # %bb.1: # %trap
+; AVX-NEXT:    vpextrq $1, %xmm0, %rdi
+; AVX-NEXT:    callq TrapFunc
+; AVX-NEXT:  .LBB1_2: # %ret
+; AVX-NEXT:    popq %rax
+; AVX-NEXT:    .cfi_def_cfa_offset 8
+; AVX-NEXT:    retq
+  %vptr = bitcast i64 * %ptr to <2 x i64> *
+  %vload = load <2 x i64>, <2 x i64> * %vptr, align 8
+  %v1 = extractelement <2 x i64> %vload, i32 0
+  %v2 = extractelement <2 x i64> %vload, i32 1
+  %vreduce = or i64 %v1, %v2
+  %vcheck = icmp eq i64 %vreduce, 0
+  br i1 %vcheck, label %ret, label %trap
+trap:
+  call void @TrapFunc(i64 %v2)
+  ret void
+ret:
+  ret void
+}
+
+define void @parseHeaders2_scalar_and(i64 * %ptr) {
+; SSE2-LABEL: parseHeaders2_scalar_and:
+; SSE2:       # %bb.0:
+; SSE2-NEXT:    pushq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 16
+; SSE2-NEXT:    movdqu (%rdi), %xmm0
+; SSE2-NEXT:    movq %xmm0, %rax
+; SSE2-NEXT:    pshufd {{.*#+}} xmm0 = xmm0[2,3,0,1]
+; SSE2-NEXT:    movq %xmm0, %rdi
+; SSE2-NEXT:    testq %rdi, %rax
+; SSE2-NEXT:    je .LBB2_2
+; SSE2-NEXT:  # %bb.1: # %trap
+; SSE2-NEXT:    callq TrapFunc
+; SSE2-NEXT:  .LBB2_2: # %ret
+; SSE2-NEXT:    popq %rax
+; SSE2-NEXT:    .cfi_def_cfa_offset 8
+; SSE2-NEXT:    retq
+;
+; SSE41-LABEL: parseHeaders2_scalar_and:
+; SSE41:       # %bb.0:
+; SSE41-NEXT:    pushq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 16
+; SSE41-NEXT:    movdqu (%rdi), %xmm0
+; SSE41-NEXT:    movq %xmm0, %rax
+; SSE41-NEXT:    pextrq $1, %xmm0, %rdi
+; SSE41-NEXT:    testq %rdi, %rax
+; SSE41-NEXT:    je .LBB2_2
+; SSE41-NEXT:  # %bb.1: # %trap
+; SSE41-NEXT:    callq TrapFunc
+; SSE41-NEXT:  .LBB2_2: # %ret
+; SSE41-NEXT:    popq %rax
+; SSE41-NEXT:    .cfi_def_cfa_offset 8
+; SSE41-NEXT:    retq
+;
+; AVX-LABEL: parseHeaders2_scalar_and:
+; AVX:       # %bb.0:
+; AVX-NEXT:    pushq %rax
+; AVX-NEXT:    .cfi_def_cfa_offset 16
+; AVX-NEXT:    vmovdqu (%rdi), %xmm0
+; AVX-NEXT:    vmovq %xmm0, %rax
+; AVX-NEXT:    vpextrq $1, %xmm0, %rdi
+; AVX-NEXT:    testq %rdi, %rax
+; AVX-NEXT:    je .LBB2_2
+; AVX-NEXT:  # %bb.1: # %trap
+; AVX-NEXT:    callq TrapFunc
+; AVX-NEXT:  .LBB2_2: # %ret
+; AVX-NEXT:    popq %rax
+; AVX-NEXT:    .cfi_def_cfa_offset 8
+; AVX-NEXT:    retq
+  %vptr = bitcast i64 * %ptr to <2 x i64> *
+  %vload = load <2 x i64>, <2 x i64> * %vptr, align 8
+  %v1 = extractelement <2 x i64> %vload, i32 0
+  %v2 = extractelement <2 x i64> %vload, i32 1
+  %vreduce = and i64 %v1, %v2
+  %vcheck = icmp eq i64 %vreduce, 0
+  br i1 %vcheck, label %ret, label %trap
+trap:
+  call void @TrapFunc(i64 %v2)
+  ret void
+ret:
+  ret void
+}