diff --git a/lldb/test/API/commands/process/launch/TestProcessLaunch.py b/lldb/test/API/commands/process/launch/TestProcessLaunch.py
index a2b27c2e5900e9..9e43c2c3fe28e8 100644
--- a/lldb/test/API/commands/process/launch/TestProcessLaunch.py
+++ b/lldb/test/API/commands/process/launch/TestProcessLaunch.py
@@ -29,6 +29,7 @@ def tearDown(self):
         TestBase.tearDown(self)
 
     @not_remote_testsuite_ready
+    @skipIfReproducer
     def test_io(self):
         """Test that process launch I/O redirection flags work properly."""
         self.build()
@@ -84,6 +85,7 @@ def test_io(self):
     @not_remote_testsuite_ready
     @expectedFailureAll(oslist=["linux"], bugnumber="llvm.org/pr20265")
     @expectedFailureNetBSD
+    @skipIfReproducer
     def test_set_working_dir_nonexisting(self):
         """Test that '-w dir' fails to set the working dir when running the inferior with a dir which doesn't exist."""
         d = {'CXX_SOURCES': 'print_cwd.cpp'}
@@ -111,6 +113,7 @@ def test_set_working_dir_nonexisting(self):
                 invalid_dir_path])
 
     @not_remote_testsuite_ready
+    @skipIfReproducer
     def test_set_working_dir_existing(self):
         """Test that '-w dir' sets the working dir when running the inferior."""
         d = {'CXX_SOURCES': 'print_cwd.cpp'}
@@ -170,6 +173,7 @@ def test_set_working_dir_existing(self):
         if not success:
             self.fail(err_msg)
 
+    @skipIfReproducer
     def test_environment_with_special_char(self):
         """Test that environment variables containing '*' and '}' are handled correctly by the inferior."""
         source = 'print_env.cpp'
diff --git a/lldb/test/API/commands/target/basic/TestTargetCommand.py b/lldb/test/API/commands/target/basic/TestTargetCommand.py
index 2704e0ed25ad18..9bc9396e19ed43 100644
--- a/lldb/test/API/commands/target/basic/TestTargetCommand.py
+++ b/lldb/test/API/commands/target/basic/TestTargetCommand.py
@@ -330,6 +330,7 @@ def test_target_create_nonexistent_core_file(self):
 
     # Write only files don't seem to be supported on Windows.
     @skipIfWindows
+    @skipIfReproducer # Cannot be captured in the VFS.
     @no_debug_info_test
     def test_target_create_unreadable_core_file(self):
         tf = tempfile.NamedTemporaryFile()
@@ -353,6 +354,7 @@ def test_target_create_invalid_core_file(self):
     # Write only files don't seem to be supported on Windows.
     @skipIfWindows
     @no_debug_info_test
+    @skipIfReproducer # Cannot be captured in the VFS.
     def test_target_create_unreadable_sym_file(self):
         tf = tempfile.NamedTemporaryFile()
         os.chmod(tf.name, stat.S_IWRITE)
diff --git a/lldb/test/API/python_api/process/io/TestProcessIO.py b/lldb/test/API/python_api/process/io/TestProcessIO.py
index 365d486650f5e4..3c1c62d2d0017a 100644
--- a/lldb/test/API/python_api/process/io/TestProcessIO.py
+++ b/lldb/test/API/python_api/process/io/TestProcessIO.py
@@ -15,6 +15,7 @@ class ProcessIOTestCase(TestBase):
     mydir = TestBase.compute_mydir(__file__)
     NO_DEBUG_INFO_TESTCASE = True
 
+    @skipIfReproducer
     def setup_test(self):
         # Get the full path to our executable to be debugged.
         self.exe = self.getBuildArtifact("process_io")