diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
index eb09d722d3046..8e50e8f7d1391 100644
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -4925,9 +4925,11 @@ void Clang::ConstructJob(Compilation &C, const JobAction &JA,
   }
 
   // Enable -mconstructor-aliases except on darwin, where we have to work around
-  // a linker bug (see <rdar://problem/7651567>), and CUDA device code, where
-  // aliases aren't supported. Similarly, aliases aren't yet supported for AIX.
-  if (!RawTriple.isOSDarwin() && !RawTriple.isNVPTX() && !RawTriple.isOSAIX())
+  // a linker bug (see <rdar://problem/7651567>), and CUDA/AMDGPU device code,
+  // where aliases aren't supported. Similarly, aliases aren't yet supported
+  // for AIX.
+  if (!RawTriple.isOSDarwin() && !RawTriple.isNVPTX() &&
+      !RawTriple.isAMDGPU() && !RawTriple.isOSAIX())
     CmdArgs.push_back("-mconstructor-aliases");
 
   // Darwin's kernel doesn't support guard variables; just die if we
diff --git a/clang/test/Driver/hip-options.hip b/clang/test/Driver/hip-options.hip
index d66eb14ca9bfd..e1050dfab1be3 100644
--- a/clang/test/Driver/hip-options.hip
+++ b/clang/test/Driver/hip-options.hip
@@ -40,3 +40,10 @@
 // RUN:   --cuda-gpu-arch=gfx906  %s 2>&1 | FileCheck -check-prefix=FIX-OVERLOAD %s
 // FIX-OVERLOAD: clang{{.*}} "-triple" "amdgcn-amd-amdhsa" {{.*}} "-fgpu-exclude-wrong-side-overloads" "-fgpu-defer-diag"
 // FIX-OVERLOAD: clang{{.*}} "-triple" "x86_64-unknown-linux-gnu" {{.*}} "-fgpu-exclude-wrong-side-overloads" "-fgpu-defer-diag"
+
+// Check -mconstructor-aliases is not passed to device compilation.
+
+// RUN: %clang -### -target x86_64-unknown-linux-gnu -nogpuinc -nogpulib \
+// RUN:   --cuda-gpu-arch=gfx906  %s 2>&1 | FileCheck -check-prefix=CTA %s
+// CTA: clang{{.*}} "-triple" "x86_64-unknown-linux-gnu" {{.*}} "-mconstructor-aliases"
+// CTA-NOT: clang{{.*}} "-triple" "amdgcn-amd-amdhsa" {{.*}} "-mconstructor-aliases"