diff --git a/llvm/test/Transforms/InstSimplify/assume-non-zero.ll b/llvm/test/Transforms/InstSimplify/assume-non-zero.ll
new file mode 100644
index 00000000000000..e69058cdf2cb9f
--- /dev/null
+++ b/llvm/test/Transforms/InstSimplify/assume-non-zero.ll
@@ -0,0 +1,229 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s -instsimplify -S | FileCheck %s
+
+target datalayout = "e-m:e-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+declare void @llvm.assume(i1) #1
+
+define i1 @nonnull0_true(i8* %x) {
+; CHECK-LABEL: @nonnull0_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp ne i8* [[X:%.*]], null
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8* [[X]], null
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp ne i8* %x, null
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8* %x, null
+  ret i1 %q
+}
+
+define i1 @nonnull1_true(i8* %x) {
+; CHECK-LABEL: @nonnull1_true(
+; CHECK-NEXT:    [[INTPTR:%.*]] = ptrtoint i8* [[X:%.*]] to i64
+; CHECK-NEXT:    [[A:%.*]] = icmp ne i64 [[INTPTR]], 0
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8* [[X]], null
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %intptr = ptrtoint i8* %x to i64
+  %a = icmp ne i64 %intptr, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8* %x, null
+  ret i1 %q
+}
+
+define i1 @nonnull2_true(i8 %x, i8 %y) {
+; CHECK-LABEL: @nonnull2_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp ugt i8 [[X:%.*]], [[Y:%.*]]
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp ugt i8 %x, %y
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+
+define i1 @nonnull3_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull3_unknown(
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X:%.*]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp uge i8 %x, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull4_true(i8 %x) {
+; CHECK-LABEL: @nonnull4_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp uge i8 [[X:%.*]], 1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp uge i8 %x, 1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+
+define i1 @nonnull5_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull5_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sgt i8 [[X:%.*]], -1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sgt i8 %x, -1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull6_true(i8 %x) {
+; CHECK-LABEL: @nonnull6_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp sgt i8 [[X:%.*]], 0
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sgt i8 %x, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull7_true(i8 %x) {
+; CHECK-LABEL: @nonnull7_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp sgt i8 [[X:%.*]], 1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sgt i8 %x, 1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+
+define i1 @nonnull8_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull8_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sge i8 [[X:%.*]], -1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sge i8 %x, -1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull9_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull9_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sge i8 [[X:%.*]], 0
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sge i8 %x, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull10_true(i8 %x) {
+; CHECK-LABEL: @nonnull10_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp sge i8 [[X:%.*]], 1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sge i8 %x, 1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+
+define i1 @nonnull11_true(i8 %x) {
+; CHECK-LABEL: @nonnull11_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp slt i8 [[X:%.*]], 0
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    ret i1 true
+;
+  %a = icmp slt i8 %x, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull12_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull12_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp slt i8 [[X:%.*]], 1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp slt i8 %x, 1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull13_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull13_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp slt i8 [[X:%.*]], 2
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp slt i8 %x, 2
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+
+define i1 @nonnull14_true(i8 %x) {
+; CHECK-LABEL: @nonnull14_true(
+; CHECK-NEXT:    [[A:%.*]] = icmp sle i8 [[X:%.*]], -1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    ret i1 true
+;
+  %a = icmp sle i8 %x, -1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull15_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull15_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sle i8 [[X:%.*]], 0
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sle i8 %x, 0
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull16_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull16_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sle i8 [[X:%.*]], 1
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sle i8 %x, 1
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}
+define i1 @nonnull17_unknown(i8 %x) {
+; CHECK-LABEL: @nonnull17_unknown(
+; CHECK-NEXT:    [[A:%.*]] = icmp sle i8 [[X:%.*]], 2
+; CHECK-NEXT:    call void @llvm.assume(i1 [[A]])
+; CHECK-NEXT:    [[Q:%.*]] = icmp ne i8 [[X]], 0
+; CHECK-NEXT:    ret i1 [[Q]]
+;
+  %a = icmp sle i8 %x, 2
+  call void @llvm.assume(i1 %a)
+  %q = icmp ne i8 %x, 0
+  ret i1 %q
+}