diff --git a/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.cpp b/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.cpp
index 26d9287f07049..edb67614bd558 100644
--- a/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.cpp
+++ b/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.cpp
@@ -277,7 +277,13 @@ class SimplifyBooleanExprCheck::Visitor : public RecursiveASTVisitor<Visitor> {
   }
 
   bool dataTraverseStmtPre(Stmt *S) {
-    if (S && !shouldIgnore(S))
+    if (!S) {
+      return true;
+    }
+    if (Check->IgnoreMacros && S->getBeginLoc().isMacroID()) {
+      return false;
+    }
+    if (!shouldIgnore(S))
       StmtStack.push_back(S);
     return true;
   }
@@ -583,6 +589,7 @@ class SimplifyBooleanExprCheck::Visitor : public RecursiveASTVisitor<Visitor> {
 SimplifyBooleanExprCheck::SimplifyBooleanExprCheck(StringRef Name,
                                                    ClangTidyContext *Context)
     : ClangTidyCheck(Name, Context),
+      IgnoreMacros(Options.get("IgnoreMacros", false)),
       ChainedConditionalReturn(Options.get("ChainedConditionalReturn", false)),
       ChainedConditionalAssignment(
           Options.get("ChainedConditionalAssignment", false)),
@@ -671,6 +678,7 @@ void SimplifyBooleanExprCheck::reportBinOp(const ASTContext &Context,
 }
 
 void SimplifyBooleanExprCheck::storeOptions(ClangTidyOptions::OptionMap &Opts) {
+  Options.store(Opts, "IgnoreMacros", IgnoreMacros);
   Options.store(Opts, "ChainedConditionalReturn", ChainedConditionalReturn);
   Options.store(Opts, "ChainedConditionalAssignment",
                 ChainedConditionalAssignment);
diff --git a/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.h b/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.h
index c4dad24ec3998..ccc6f3d879fc0 100644
--- a/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.h
+++ b/clang-tools-extra/clang-tidy/readability/SimplifyBooleanExprCheck.h
@@ -64,6 +64,7 @@ class SimplifyBooleanExprCheck : public ClangTidyCheck {
                  StringRef Description, SourceRange ReplacementRange,
                  StringRef Replacement);
 
+  const bool IgnoreMacros;
   const bool ChainedConditionalReturn;
   const bool ChainedConditionalAssignment;
   const bool SimplifyDeMorgan;
diff --git a/clang-tools-extra/docs/ReleaseNotes.rst b/clang-tools-extra/docs/ReleaseNotes.rst
index f202e051aad16..07d788851f8d1 100644
--- a/clang-tools-extra/docs/ReleaseNotes.rst
+++ b/clang-tools-extra/docs/ReleaseNotes.rst
@@ -496,6 +496,11 @@ Changes in existing checks
   <clang-tidy/checks/readability/non-const-parameter>` check to ignore
   false-positives in initializer list of record.
 
+- Improved :doc:`readability-simplify-boolean-expr
+  <clang-tidy/checks/readability/simplify-boolean-expr>` check by adding the
+  new option `IgnoreMacros` that allows to ignore boolean expressions originating
+  from expanded macros.
+
 - Improved :doc:`readability-simplify-subscript-expr
   <clang-tidy/checks/readability/simplify-subscript-expr>` check by extending
   the default value of the `Types` option to include ``std::span``.
diff --git a/clang-tools-extra/docs/clang-tidy/checks/readability/simplify-boolean-expr.rst b/clang-tools-extra/docs/clang-tidy/checks/readability/simplify-boolean-expr.rst
index 18ab84b26a259..3d00d5b043a60 100644
--- a/clang-tools-extra/docs/clang-tidy/checks/readability/simplify-boolean-expr.rst
+++ b/clang-tools-extra/docs/clang-tidy/checks/readability/simplify-boolean-expr.rst
@@ -82,6 +82,11 @@ Examples:
 Options
 -------
 
+.. option:: IgnoreMacros
+
+   If `true`, ignore boolean expressions originating from expanded macros.
+   Default is `false`.
+
 .. option:: ChainedConditionalReturn
 
    If `true`, conditional boolean return statements at the end of an
@@ -99,8 +104,8 @@ Options
 
 .. option:: SimplifyDeMorganRelaxed
 
-   If `true`, :option:`SimplifyDeMorgan` will also transform negated 
-   conjunctions and disjunctions where there is no negation on either operand. 
+   If `true`, :option:`SimplifyDeMorgan` will also transform negated
+   conjunctions and disjunctions where there is no negation on either operand.
    This option has no effect if :option:`SimplifyDeMorgan` is `false`.
    Default is `false`.
 
diff --git a/clang-tools-extra/test/clang-tidy/checkers/readability/simplify-boolean-expr-macros.cpp b/clang-tools-extra/test/clang-tidy/checkers/readability/simplify-boolean-expr-macros.cpp
new file mode 100644
index 0000000000000..7d0cfe7e27dc2
--- /dev/null
+++ b/clang-tools-extra/test/clang-tidy/checkers/readability/simplify-boolean-expr-macros.cpp
@@ -0,0 +1,20 @@
+// RUN: %check_clang_tidy -check-suffixes=,MACROS %s readability-simplify-boolean-expr %t
+
+// Ignore expressions in macros.
+// RUN: %check_clang_tidy %s readability-simplify-boolean-expr %t \
+// RUN:     -- -config="{CheckOptions: {readability-simplify-boolean-expr.IgnoreMacros: true}}" \
+// RUN:     --
+
+#define NEGATE(expr) !(expr)
+
+bool without_macro(bool a, bool b) {
+    return !(!a && b);
+    // CHECK-MESSAGES: :[[@LINE-1]]:12: warning: boolean expression can be simplified by DeMorgan's theorem
+    // CHECK-FIXES: return a || !b;
+}
+
+bool macro(bool a, bool b) {
+    return NEGATE(!a && b);
+    // CHECK-MESSAGES-MACROS: :[[@LINE-1]]:12: warning: boolean expression can be simplified by DeMorgan's theorem
+    // CHECK-FIXES: return NEGATE(!a && b);
+}