diff --git a/compiler-rt/test/profile/Posix/instrprof-gcov-execlp.test b/compiler-rt/test/profile/Posix/instrprof-gcov-execlp.test
index 1d136ce97907e..f9d7614fa91bf 100644
--- a/compiler-rt/test/profile/Posix/instrprof-gcov-execlp.test
+++ b/compiler-rt/test/profile/Posix/instrprof-gcov-execlp.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/Posix/instrprof-gcov-execvp.test b/compiler-rt/test/profile/Posix/instrprof-gcov-execvp.test
index 8e5cbc6095092..c1fc35aa36bde 100644
--- a/compiler-rt/test/profile/Posix/instrprof-gcov-execvp.test
+++ b/compiler-rt/test/profile/Posix/instrprof-gcov-execvp.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/Posix/instrprof-gcov-fork.test b/compiler-rt/test/profile/Posix/instrprof-gcov-fork.test
index 31b6a23be49cd..79319528c5b34 100644
--- a/compiler-rt/test/profile/Posix/instrprof-gcov-fork.test
+++ b/compiler-rt/test/profile/Posix/instrprof-gcov-fork.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 UNSUPPORTED: linux
 UNSUPPORTED: darwin
 
diff --git a/compiler-rt/test/profile/Posix/instrprof-gcov-parallel.test b/compiler-rt/test/profile/Posix/instrprof-gcov-parallel.test
index 90857ebb3c32a..fe0bf590f0938 100644
--- a/compiler-rt/test/profile/Posix/instrprof-gcov-parallel.test
+++ b/compiler-rt/test/profile/Posix/instrprof-gcov-parallel.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 # Work around PR45673 until the test code is fixed
 # ALLOW_RETRIES: 2
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-multiple.test b/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-multiple.test
index fdc93c93e0b06..3eeb43c295dd5 100644
--- a/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-multiple.test
+++ b/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-multiple.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-terminate.test b/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-terminate.test
index aa51461a3bd08..4b7bccb1329af 100644
--- a/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-terminate.test
+++ b/compiler-rt/test/profile/instrprof-gcov-__gcov_flush-terminate.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 XFAIL: *
 
 RUN: mkdir -p %t.d
diff --git a/compiler-rt/test/profile/instrprof-gcov-exceptions.test b/compiler-rt/test/profile/instrprof-gcov-exceptions.test
index a3dcc55aaf5b6..b6eab2b8c5661 100644
--- a/compiler-rt/test/profile/instrprof-gcov-exceptions.test
+++ b/compiler-rt/test/profile/instrprof-gcov-exceptions.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-multiple-bbs-single-line.test b/compiler-rt/test/profile/instrprof-gcov-multiple-bbs-single-line.test
index 66b6429208a0f..46cb120a50846 100644
--- a/compiler-rt/test/profile/instrprof-gcov-multiple-bbs-single-line.test
+++ b/compiler-rt/test/profile/instrprof-gcov-multiple-bbs-single-line.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-one-line-function.test b/compiler-rt/test/profile/instrprof-gcov-one-line-function.test
index d67c21a863bfc..82da731961d15 100644
--- a/compiler-rt/test/profile/instrprof-gcov-one-line-function.test
+++ b/compiler-rt/test/profile/instrprof-gcov-one-line-function.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-switch.test b/compiler-rt/test/profile/instrprof-gcov-switch.test
index 9c43a93dc646a..ade54c9784f4c 100644
--- a/compiler-rt/test/profile/instrprof-gcov-switch.test
+++ b/compiler-rt/test/profile/instrprof-gcov-switch.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d
 
diff --git a/compiler-rt/test/profile/instrprof-gcov-two-objects.test b/compiler-rt/test/profile/instrprof-gcov-two-objects.test
index 4080caa7fdd9a..9ba3124110973 100644
--- a/compiler-rt/test/profile/instrprof-gcov-two-objects.test
+++ b/compiler-rt/test/profile/instrprof-gcov-two-objects.test
@@ -1,3 +1,4 @@
+UNSUPPORTED: host-byteorder-big-endian
 RUN: mkdir -p %t.d
 RUN: cd %t.d