diff --git a/llvm/lib/Target/Hexagon/HexagonVectorCombine.cpp b/llvm/lib/Target/Hexagon/HexagonVectorCombine.cpp
index a605fdfcf10015..57ef4470dbb112 100644
--- a/llvm/lib/Target/Hexagon/HexagonVectorCombine.cpp
+++ b/llvm/lib/Target/Hexagon/HexagonVectorCombine.cpp
@@ -521,11 +521,6 @@ auto AlignVectors::createAddressGroups() -> bool {
     return !llvm::any_of(
         G.second, [&](auto &I) { return HVC.HST.isTypeForHVX(I.ValTy); });
   });
-  // Remove groups where everything is properly aligned.
-  erase_if(AddrGroups, [&](auto &G) {
-    return llvm::all_of(G.second,
-                        [&](auto &I) { return I.HaveAlign >= I.NeedAlign; });
-  });
 
   return !AddrGroups.empty();
 }
@@ -1382,6 +1377,11 @@ auto HexagonVectorCombine::isSafeToMoveBeforeInBB(const Instruction &In,
     const Instruction &I = *It;
     if (llvm::is_contained(Ignore, &I))
       continue;
+    // assume intrinsic can be ignored
+    if (auto *II = dyn_cast<IntrinsicInst>(&I)) {
+      if (II->getIntrinsicID() == Intrinsic::assume)
+        continue;
+    }
     // Parts based on isSafeToMoveBefore from CoveMoverUtils.cpp.
     if (I.mayThrow())
       return false;
diff --git a/llvm/test/CodeGen/Hexagon/vcombine_zero_diff_ptrs.ll b/llvm/test/CodeGen/Hexagon/vcombine_zero_diff_ptrs.ll
new file mode 100644
index 00000000000000..a105873c83484f
--- /dev/null
+++ b/llvm/test/CodeGen/Hexagon/vcombine_zero_diff_ptrs.ll
@@ -0,0 +1,38 @@
+; RUN: opt -march=hexagon -hexagon-vc < %s | FileCheck %s
+
+; Test that the HexagonVectorCombine pass identifies instruction
+; pairs whose difference in pointers is zero. This creates a vector
+; load to handle masked and unmasked loads that have no base
+; pointer difference and replaces the masked and unmasked loads
+; with selects
+
+; CHECK: select
+
+target datalayout = "e-m:e-p:32:32:32-a:0-n16:32-i64:64:64-i32:32:32-i16:16:16-i1:8:8-f32:32:32-f64:64:64-v32:32:32-v64:64:64-v512:512:512-v1024:1024:1024-v2048:2048:2048"
+target triple = "hexagon"
+
+define dllexport void @f0(i8** %a0) local_unnamed_addr #0 {
+b0:
+  %v0 = load i8*, i8** %a0, align 4
+  %v1 = getelementptr i8, i8* %v0, i32 1794
+  %v2 = bitcast i8* %v1 to <64 x i16>*
+  call void @llvm.assume(i1 true) [ "align"(i8* %v0, i32 128) ]
+  %v3 = load <64 x i16>, <64 x i16>* %v2, align 128
+  %v4 = add <64 x i16> %v3, %v3
+  call void @llvm.assume(i1 true) [ "align"(i8* %v0, i32 128) ]
+  %v5 = tail call <64 x i16> @llvm.masked.load.v64i16.p0v64i16(<64 x i16>* %v2, i32 128, <64 x i1> <i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true, i1 false, i1 true>, <64 x i16> undef)
+  call void @llvm.assume(i1 true) [ "align"(i8* %v0, i32 128) ]
+  %v6 = add <64 x i16> %v4, %v5
+  store <64 x i16> %v6, <64 x i16>* %v2, align 128
+  ret void
+}
+
+; Function Attrs: nofree nosync nounwind willreturn
+declare void @llvm.assume(i1 noundef) #1
+
+; Function Attrs: argmemonly nofree nosync nounwind readonly willreturn
+declare <64 x i16> @llvm.masked.load.v64i16.p0v64i16(<64 x i16>*, i32 immarg, <64 x i1>, <64 x i16>) #2
+
+attributes #0 = { "target-features"="+hvxv68,+hvx-length128b,+hvxv68,+hvx-length128b" }
+attributes #1 = { nofree nosync nounwind willreturn }
+attributes #2 = { argmemonly nofree nosync nounwind readonly willreturn }