diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
index 2d2a998b750fe..4c34d56526ffe 100644
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -6683,7 +6683,6 @@ Instruction *InstCombinerImpl::visitFCmpInst(FCmpInst &I) {
     if (match(Op1, m_FPExt(m_Value(Y))) && X->getType() == Y->getType())
       return new FCmpInst(Pred, X, Y, "", &I);
 
-    // fcmp (fpext X), C -> fcmp X, (fptrunc C) if fptrunc is lossless
     const APFloat *C;
     if (match(Op1, m_APFloat(C))) {
       const fltSemantics &FPSem =
@@ -6692,6 +6691,31 @@ Instruction *InstCombinerImpl::visitFCmpInst(FCmpInst &I) {
       APFloat TruncC = *C;
       TruncC.convert(FPSem, APFloat::rmNearestTiesToEven, &Lossy);
 
+      if (Lossy) {
+        // X can't possibly equal the higher-precision constant, so reduce any
+        // equality comparison.
+        // TODO: Other predicates can be handled via getFCmpCode().
+        switch (Pred) {
+        case FCmpInst::FCMP_OEQ:
+          // X is ordered and equal to an impossible constant --> false
+          return replaceInstUsesWith(I, ConstantInt::getFalse(I.getType()));
+        case FCmpInst::FCMP_ONE:
+          // X is ordered and not equal to an impossible constant --> ordered
+          return new FCmpInst(FCmpInst::FCMP_ORD, X,
+                              ConstantFP::getNullValue(X->getType()));
+        case FCmpInst::FCMP_UEQ:
+          // X is unordered or equal to an impossible constant --> unordered
+          return new FCmpInst(FCmpInst::FCMP_UNO, X,
+                              ConstantFP::getNullValue(X->getType()));
+        case FCmpInst::FCMP_UNE:
+          // X is unordered or not equal to an impossible constant --> true
+          return replaceInstUsesWith(I, ConstantInt::getTrue(I.getType()));
+        default:
+          break;
+        }
+      }
+
+      // fcmp (fpext X), C -> fcmp X, (fptrunc C) if fptrunc is lossless
       // Avoid lossy conversions and denormals.
       // Zero is a special case that's OK to convert.
       APFloat Fabs = TruncC;
diff --git a/llvm/test/Transforms/InstCombine/fcmp.ll b/llvm/test/Transforms/InstCombine/fcmp.ll
index b0211d52f197f..7ababebe3b0dd 100644
--- a/llvm/test/Transforms/InstCombine/fcmp.ll
+++ b/llvm/test/Transforms/InstCombine/fcmp.ll
@@ -674,9 +674,7 @@ define i1 @is_signbit_set_simplify_nan(double %x) {
 
 define <2 x i1> @lossy_oeq(<2 x float> %x) {
 ; CHECK-LABEL: @lossy_oeq(
-; CHECK-NEXT:    [[E:%.*]] = fpext <2 x float> [[X:%.*]] to <2 x double>
-; CHECK-NEXT:    [[R:%.*]] = fcmp oeq <2 x double> [[E]], <double 1.000000e-01, double 1.000000e-01>
-; CHECK-NEXT:    ret <2 x i1> [[R]]
+; CHECK-NEXT:    ret <2 x i1> zeroinitializer
 ;
   %e = fpext <2 x float> %x to <2 x double>
   %r = fcmp oeq <2 x double> %e, <double 0.1, double 0.1>
@@ -687,7 +685,7 @@ define i1 @lossy_one(float %x, double* %p) {
 ; CHECK-LABEL: @lossy_one(
 ; CHECK-NEXT:    [[E:%.*]] = fpext float [[X:%.*]] to double
 ; CHECK-NEXT:    store double [[E]], double* [[P:%.*]], align 8
-; CHECK-NEXT:    [[R:%.*]] = fcmp one double [[E]], 1.000000e-01
+; CHECK-NEXT:    [[R:%.*]] = fcmp ord float [[X]], 0.000000e+00
 ; CHECK-NEXT:    ret i1 [[R]]
 ;
   %e = fpext float %x to double
@@ -698,8 +696,7 @@ define i1 @lossy_one(float %x, double* %p) {
 
 define i1 @lossy_ueq(half %x) {
 ; CHECK-LABEL: @lossy_ueq(
-; CHECK-NEXT:    [[E:%.*]] = fpext half [[X:%.*]] to double
-; CHECK-NEXT:    [[R:%.*]] = fcmp ueq double [[E]], 6.553600e+04
+; CHECK-NEXT:    [[R:%.*]] = fcmp uno half [[X:%.*]], 0xH0000
 ; CHECK-NEXT:    ret i1 [[R]]
 ;
   %e = fpext half %x to double
@@ -709,9 +706,7 @@ define i1 @lossy_ueq(half %x) {
 
 define i1 @lossy_une(half %x) {
 ; CHECK-LABEL: @lossy_une(
-; CHECK-NEXT:    [[E:%.*]] = fpext half [[X:%.*]] to float
-; CHECK-NEXT:    [[R:%.*]] = fcmp une float [[E]], 2.049000e+03
-; CHECK-NEXT:    ret i1 [[R]]
+; CHECK-NEXT:    ret i1 true
 ;
   %e = fpext half %x to float
   %r = fcmp une float %e, 2049.0