diff --git a/clang/test/Interpreter/simple-exception.cpp b/clang/test/Interpreter/simple-exception.cpp
index 886b8ffd2d7017..8741886a0a621c 100644
--- a/clang/test/Interpreter/simple-exception.cpp
+++ b/clang/test/Interpreter/simple-exception.cpp
@@ -3,6 +3,11 @@
 // XFAIL for arm, arm64, riscv, or running on Windows.
 // XFAIL: target={{(arm|riscv).*}}, system-windows
 // RUN: cat %s | clang-repl | FileCheck %s
+
+// Incompatible with msan. It passes with -O3 but fail -Oz. Interpreter
+// generates non-instrumented code, which may call back to instrumented.
+// UNSUPPORTED: msan
+
 extern "C" int printf(const char *, ...);
 
 int f() { throw "Simple exception"; return 0; }