diff --git a/clang/lib/Headers/opencl-c-base.h b/clang/lib/Headers/opencl-c-base.h
index c433b4f7eb1af..fad2f9c0272bf 100644
--- a/clang/lib/Headers/opencl-c-base.h
+++ b/clang/lib/Headers/opencl-c-base.h
@@ -74,6 +74,25 @@
 #define __opencl_c_atomic_scope_all_devices 1
 #define __opencl_c_read_write_images 1
 #endif // defined(__SPIR__)
+
+// Undefine any feature macros that have been explicitly disabled using
+// an __undef_<feature> macro.
+#ifdef __undef___opencl_c_work_group_collective_functions
+#undef __opencl_c_work_group_collective_functions
+#endif
+#ifdef __undef___opencl_c_atomic_order_seq_cst
+#undef __opencl_c_atomic_order_seq_cst
+#endif
+#ifdef __undef___opencl_c_atomic_scope_device
+#undef __opencl_c_atomic_scope_device
+#endif
+#ifdef __undef___opencl_c_atomic_scope_all_devices
+#undef __opencl_c_atomic_scope_all_devices
+#endif
+#ifdef __undef___opencl_c_read_write_images
+#undef __opencl_c_read_write_images
+#endif
+
 #endif // (__OPENCL_CPP_VERSION__ == 202100 || __OPENCL_C_VERSION__ == 300)
 
 #if !defined(__opencl_c_generic_address_space)
diff --git a/clang/test/SemaOpenCL/features.cl b/clang/test/SemaOpenCL/features.cl
index af058b5e69828..3f59b4ea3b5ae 100644
--- a/clang/test/SemaOpenCL/features.cl
+++ b/clang/test/SemaOpenCL/features.cl
@@ -26,6 +26,15 @@
 // RUN: %clang_cc1 -triple spir-unknown-unknown %s -E -dM -o - -x cl -cl-std=clc++1.0 \
 // RUN:   | FileCheck -match-full-lines %s  --check-prefix=NO-FEATURES
 
+// For OpenCL C 3.0, header-only features can be disabled using macros.
+// RUN: %clang_cc1 -triple spir-unknown-unknown %s -E -dM -o - -x cl -cl-std=CL3.0 -fdeclare-opencl-builtins -finclude-default-header \
+// RUN:    -D__undef___opencl_c_work_group_collective_functions=1 \
+// RUN:    -D__undef___opencl_c_atomic_order_seq_cst=1 \
+// RUN:    -D__undef___opencl_c_atomic_scope_device=1 \
+// RUN:    -D__undef___opencl_c_atomic_scope_all_devices=1 \
+// RUN:    -D__undef___opencl_c_read_write_images=1 \
+// RUN:   | FileCheck %s --check-prefix=NO-HEADERONLY-FEATURES
+
 // Note that __opencl_c_int64 is always defined assuming
 // always compiling for FULL OpenCL profile
 
@@ -43,14 +52,20 @@
 // FEATURES: #define __opencl_c_subgroups 1
 
 // NO-FEATURES: #define __opencl_c_int64 1
-// NO-FEATURES-NOT: __opencl_c_3d_image_writes
-// NO-FEATURES-NOT: __opencl_c_atomic_order_acq_rel
-// NO-FEATURES-NOT: __opencl_c_atomic_order_seq_cst
-// NO-FEATURES-NOT: __opencl_c_device_enqueue
-// NO-FEATURES-NOT: __opencl_c_fp64
-// NO-FEATURES-NOT: __opencl_c_generic_address_space
-// NO-FEATURES-NOT: __opencl_c_images
-// NO-FEATURES-NOT: __opencl_c_pipes
-// NO-FEATURES-NOT: __opencl_c_program_scope_global_variables
-// NO-FEATURES-NOT: __opencl_c_read_write_images
-// NO-FEATURES-NOT: __opencl_c_subgroups
+// NO-FEATURES-NOT: #define __opencl_c_3d_image_writes
+// NO-FEATURES-NOT: #define __opencl_c_atomic_order_acq_rel
+// NO-FEATURES-NOT: #define __opencl_c_atomic_order_seq_cst
+// NO-FEATURES-NOT: #define __opencl_c_device_enqueue
+// NO-FEATURES-NOT: #define __opencl_c_fp64
+// NO-FEATURES-NOT: #define __opencl_c_generic_address_space
+// NO-FEATURES-NOT: #define __opencl_c_images
+// NO-FEATURES-NOT: #define __opencl_c_pipes
+// NO-FEATURES-NOT: #define __opencl_c_program_scope_global_variables
+// NO-FEATURES-NOT: #define __opencl_c_read_write_images
+// NO-FEATURES-NOT: #define __opencl_c_subgroups
+
+// NO-HEADERONLY-FEATURES-NOT: #define __opencl_c_work_group_collective_functions
+// NO-HEADERONLY-FEATURES-NOT: #define __opencl_c_atomic_order_seq_cst
+// NO-HEADERONLY-FEATURES-NOT: #define __opencl_c_atomic_scope_device
+// NO-HEADERONLY-FEATURES-NOT: #define __opencl_c_atomic_scope_all_devices
+// NO-HEADERONLY-FEATURES-NOT: #define __opencl_c_read_write_images